Postprandial hypotension (PPH) is common in older adults and those with autonomic dysfunction, commonly with Diabetes Mellitus (DM).This study proposed to demonstrate that Acarbose, an α-glucosidase inhibitor, decreases the degree of PPH in an elderly DM cohort. 15 adults (9 women, 6 men) with average age of 76.06 years (range: 67-85.2) with DM type 2 (Duration: 8.7 years±7.4 ; Hemoglobin A 1 C 6.9%±0.8) attended a treatment and placebo session (separate days at least two weeks apart) in random double-blinded order. Subjects were fed a standardized meal (4 o C) and then continuously monitored over 90 minutes for blood pressure by Finometry, heart rate by Electrocardiogram, and middle cerebral artery blood flow velocity by transcranial Doppler Sonogram (20-minute baseline recorded for all measurements), blood glucose and catecholamine measurements. The frequency of PPH occurring per study was 0.8 (range: 1-3) for Acarbose and 1.46 (range: 0-3) for placebo (p=0.0359). The hemodynamic response of systolic blood pressure (SBP) and mean arterial pressure (MAP) (baseline as covariante) was significantly different by mixed-model repeated measures two-factor (time and treatment) analysis of variance (SBP: p=0.0295; MAP: p=0.0354). This is the first study to demonstrate Acarbose attenuates PPH in adults with DM. Our results suggest that acarbose is a potential therapy for PPH in older adults with DM type 2. The reported higher prevalence of PPH in our study warrants further investigation.