Association of premenstrual/menstrual symptoms with perinatal depression and a polymorphic repeat in the polyglutamine tract of the retinoic acid induced 1 gene

Tan, Eng Leong; Tan, H. H.; Chua, Tze-Ern; Lee, Theresa; Ng, Jasmine; Ch’ng, Ying-Chia; Choo, Chih-Huei; Chen, Helen Y.

doi:10.1016/j.jad.2014.03.006

Cited by 7 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Cases were defined as patients with confirmed clinical diagnosis of PPD as assessed at the outpatient clinic by board-certified psychiatrists using the Diagnostic and Statistical Manual for Mental Disorders criteria for major depression of postpartum onset. 17 These patients were referred from screening in the clinic or from the obstetric wards. Patients with psychotic disorders, comorbid predominant anxiety, or substance abuse were excluded.…”

Section: Methodsmentioning

confidence: 99%

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study

Suhitharan¹,

Pham²,

Chen³

et al. 2016

NDT

Self Cite

View full text Add to dashboard Cite

AimThe aim of this study was to investigate the role of peripartum analgesic and psychological factors that may be related to postpartum depression (PPD).MethodsThis case–control study was conducted in pregnant females who delivered at KK Women’s and Children’s Hospital from November 2010 to October 2013 and had postpartum psychological assessment. Demographic, medical, and postpartum psychological status assessments, intrapartum data including method of induction of labor, mode of labor analgesia, duration of first and second stages of labor, mode of delivery, and pain intensity on hospital admission and after delivery were collected. PPD was assessed using the Edinburgh Postnatal Depression Scale and clinical assessment by the psychiatrist.ResultsThere were 62 cases of PPD and 417 controls after childbirth within 4–8 weeks. The odds of PPD was significantly lower (33 of 329 [10.0%]) in females who received epidural analgesia for labor compared with those who chose nonepidural analgesia (29 of 150 [19.3%]) ([odds ratio] 0.47 (0.27–0.8), P=0.0078). The multivariate analysis showed that absence of labor epidural analgesia, increasing age, family history of depression, history of depression, and previous history of PPD were independent risk factors for development of PPD.ConclusionThe absence of labor epidural analgesia remained as an independent risk factor for development of PPD when adjusted for psychiatric predictors of PPD such as history of depression or PPD and family history of depression.

show abstract

Section: Methodsmentioning

confidence: 99%

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study

Suhitharan¹,

Pham²,

Chen³

et al. 2016

NDT

Self Cite

View full text Add to dashboard Cite

show abstract

“…Written informed consent of the participants was obtained after the procedures had been fully explained to them. The study sample has been described in a previous report [ 32 ]. In short, cases were recruited from outpatient psychiatric clinics and were all diagnosed by board-certified psychiatrists according to the criteria in Diagnostic Statistical Manual of Mental Disorders IV edition.…”

Section: Methodsmentioning

confidence: 99%

Case-control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depression

Tan

Chua

Lee

et al. 2015

BMC Pregnancy Childbirth

Self Cite

View full text Add to dashboard Cite

BackgroundDepression during pregnancy or after childbirth is the most frequent perinatal illness affecting women of reproductive age. It could result in unfavourable outcomes for both women and their newborns. The incidence of perinatal depression is higher for those with family history of depression and other mental illness, suggesting the contribution of genetic factors. There is postulation that disruption or fluctuation of reproductive hormones could play a part in women who are sensitive to such changes.MethodsThis is a case-control study comparing the frequencies of candidate gene variants in patients with perinatal depression with controls. Patients of Chinese descent (N = 725) were recruited from the outpatient clinics of the hospital between 2010 and 2013. Controls were patients who came for postnatal consultations at the obstetrics clinics and scored ≤ 7 on the Edinburgh Postnatal Depression Scale (EPDS) at the postnatal screening programme of the hospital. Cases with confirmed diagnosis of clinical (major) depression related to pregnancy/postpartum were recruited from the hospital’s outpatient clinic. Genomic DNA was extracted from saliva samples and genotyped for the polymorphisms of interest. Differences between groups were assessed by chi-square analysis.ResultsCRHR1 rs242939 and rs1876828 were not polymorphic in the study population. There was no statistically significant association of perinatal depression for CRHR1 rs242941 and GR rs41423247 (BclI). When all subjects were grouped based on family history of mental illness, there was a statistically significant association of CRHR1 rs242941 with family history regardless of depression status (P = 0.043). There was also a statistically significant difference for GR rs41423247 and regularity of menstrual periods (P < 0.000). Although not statistically significant, women with perinatal depression showed a trend towards higher frequency of self-reported menstrual irregularity.ConclusionsNo evidence was found for the association of any of the genetic markers with perinatal depression in this study cohort. Instead, the possible genetic links were found in women with positive family history of mental illness and menstrual irregularity, suggesting these could be identifying risk markers for women.

show abstract

“…Associations with MTHFR (Lewis et al, 2012) and TPH2 were observed at 24-32 weeks postpartum, but not during the first week postpartum, and significant associations were also observed for GR, CRHR1 (Engineer et al, 2013), HMNC1 (Alvim-Soares et al, 2014) and RAI1 polymorphisms (Tan et al, 2014).…”

Section: Postpartum Depressionmentioning

confidence: 99%

The Influence of genetic factors on peripartum depression: A systematic review

Figueiredo

Parada

Araújo

et al. 2015

Journal of Affective Disorders

View full text Add to dashboard Cite

Association of premenstrual/menstrual symptoms with perinatal depression and a polymorphic repeat in the polyglutamine tract of the retinoic acid induced 1 gene

Cited by 7 publications

References 25 publications

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study

Case-control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depression

The Influence of genetic factors on peripartum depression: A systematic review

Contact Info

Product

Resources

About

Association of premenstrual/menstrual symptoms with perinatal depression and a polymorphic repeat in the polyglutamine tract of the retinoic acid induced 1 gene

Cited by 7 publications

References 25 publications

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case&ndash;control study

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case&ndash;control study

Case-control study of glucocorticoid receptor and corticotrophin-releasing hormone receptor gene variants and risk of perinatal depression

The Influence of genetic factors on peripartum depression: A systematic review

Contact Info

Product

Resources

About

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study

Investigating analgesic and psychological factors associated with risk of postpartum depression development: a case–control study