Association of Pretransplantion Opioid Use with Graft Loss or Death in Liver Transplantation Patients with Model of End-Stage Liver Disease Exceptions

Chronic opioid use and clinical outcomes in lung transplant recipients: A single‐center cohort study

“…Consistent with data from the general population, liver transplant recipients with a history of pre‐transplant opioid use were more likely to be readmitted or hospitalized at 30 days and 1‐year post‐transplant . However, data on long‐term opioid use after abdominal organ transplantation have not been published . In our analysis of chronic opioid use during the 1‐5 year post‐LTx period, this factor was not associated with increased ED visits, urgent care visits, or hospitalizations.…”

“…Our results suggest that chronic opioid use is at least as common in LTx recipients as in abdominal transplant recipients, according to recent reports. Particularly, 33% of liver transplant recipients received opioid therapy prior to transplantation, while 11% of kidney transplant recipients continued to receive chronic opioid therapy for pain 1 year after transplant . Medications such as acetaminophen and nonsteroidal anti‐inflammatory drugs are relatively contraindicated in liver and kidney transplant recipients, which may have led providers to prescribe opioids more often in those cohorts .…”

“…Chronic post‐transplant pain has traditionally been managed via pharmacotherapy, despite the unique circumstances facing transplant patients. Indeed, opioid therapy for chronic post‐transplant pain was recently shown to predict increased risk of re‐hospitalization and other adverse events in adult recipients of kidney and liver transplants . Adult liver recipients with a history of pre‐transplant chronic opioid use were also more likely to experience graft loss and death …”

“…Indeed, opioid therapy for chronic post-transplant pain was recently shown to predict increased risk of re-hospitalization and other adverse events in adult recipients of kidney and liver transplants. [6][7][8] Adult liver recipients with a history of pre-transplant chronic opioid use were also more likely to experience graft loss and death. 8 Despite evidence of increased post-transplant adverse events associated with chronic opioid use in abdominal transplant recipients, the association of long-term opioid use with LTx outcomes remains unknown.…”

“…[6][7][8] Adult liver recipients with a history of pre-transplant chronic opioid use were also more likely to experience graft loss and death. 8 Despite evidence of increased post-transplant adverse events associated with chronic opioid use in abdominal transplant recipients, the association of long-term opioid use with LTx outcomes remains unknown. A multitude of causes might contribute to potential clinical deterioration among LTx patients receiving chronic opioid pain therapy.…”