Association of (Pro)renin Receptor mRNA Expression with Angiotensin-Converting Enzyme mRNA Expression in Human Artery

Takemitsu, Tomoko; Ichihara, Atsuhiro; Kaneshiro, Yuki; Sakoda, Mariyo; Kurauchi-Mito, Asako; Narita, Tatsuya; Kinouchi, Kenichiro; Yamashita, Norimasa; Itoh, Hiroshi

doi:10.1159/000232199

Cited by 11 publications

(10 citation statements)

References 69 publications

(59 reference statements)

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“…Consistent with the findings of the study of Takemitsu et al [20], neither plasma prorenin level nor (P)RR expression in PBMCs correlated with SBP and DBP in non-DM-HD patients in the present study. Hirose et al [21] Clin Exp Nephrol (2011) 15:398-404 401 reported the association of (P)RR gene polymorphism with SBP and DBP in Japanese men.…”

Section: Discussionsupporting

confidence: 92%

“…Takemitsu et al [20] also reported that plasma prorenin concentration correlated with PRA, plasma AT I level, plasma AT II level and plasma Ald level in non-DM-HD patients. In the present study, plasma prorenin level did not correlate with PRA, plasma AT I level, plasma AT II level or plasma Ald level.…”

Section: Discussionmentioning

confidence: 89%

“…The other possibility is that antihypertensive drugs may affect RAS regulation. Although Takemitsu et al [20] included the non-DM-HD patients who received ACEI and ARBs, the present study did not include non-DM-HD patients who received these antihypertensives. Further study will be needed to clarify the mechanism of prorenin and PRR regulation in non-DM-HD patients.…”

Section: Discussionmentioning

confidence: 94%

“…Increased ROS induced monocyte inflammation followed by proinflammatory gene expression [18,19]. Takemitsu et al [20] reported that arterial (P)RR may contribute to activate arterial tissue RAS in HD patients, since arterial (P)RR mRNA expression correlated with arterial ACE mRNA expression. In the present study, (P)RR expression in PBMCs significantly increased in non-DM-HD patients.…”

Section: Discussionmentioning

confidence: 99%

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The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

et al. 2011

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

et al. 2011

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“…32 The plasma prorenin levels in diabetic patients were significantly higher than those in non-diabetic patients. Nevertheless, arterial (P)RR expression was similar in diabetic and non-diabetic patients, suggesting that the negative feedback mechanism of the (P)RR observed in cultured cells 26,27 does not work in diabetic patients.…”

Section: Arterial Mrna Levels In Patients With Stage 5 Chronic Kidneymentioning

confidence: 89%

Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings

et al. 2009

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Numerous in vitro and in vivo animal studies using the (pro)renin receptor (P)RR blocker handle region peptide have suggested an important role of (P)RR in the pathogenesis of end-stage organ damage in patients with diabetes and hypertension. In addition, a limited number of clinical studies have suggested an association between (P)RR gene polymorphisms and blood pressure levels and between (P)RR mRNA levels and angiotensin-converting enzyme mRNA levels in human arteries. However, recent studies have shown that the (P)RR is divided into its soluble form and a residual hydrophobic part, which includes ATPase 6 associated protein 2, within cells. Therefore, the (P)RR may have a more complex function than previously thought. In addition, the physiological roles of the (P)RR remain undetermined, because the construction of (P)RR null mice has not been successful. As a next step for research in this area, a method for determining the soluble (P)RR levels in plasma and urine and the construction of tissue-specific (P)RR-knockout mice are needed to elucidate the roles of the (P)RR in physiology and pathophysiology. Hypertension Research (2010) 33, 177-180; doi:10.1038/hr.2009 published online 18 December 2009 Keywords: angiotensin; ATP6ap2; handle region peptide; prorenin; vacuolar H + -ATPase INTRODUCTIONThe pathophysiological roles of the (pro)renin receptor ((P)RR) are a growing concern because numerous experimental studies conducted since this receptor was first discovered in 2002 1 have suggested that the pro(renin) receptor has its own intracellular signaling pathways and is involved in the tissue renin-angiotensin system. However, the clinical relevance of the human (P)RR remains uncertain because only a few clinical studies examining the (P)RR have been performed. In this review article of previous studies and new findings, we attempt to elucidate the possible role of the (P)RR in humans. SUGGESTIONS FROM IN VITRO STUDIESThe (P)RR was first reported to be capable of binding both renin and prorenin in vitro. 1 However, Batenburg et al. 2 showed that prorenin, but not renin, was capable of binding to the (P)RR in cultured vascular smooth muscle cells, suggesting that prorenin is an endogenous agonist of the (P)RR. In addition, Nabi et al. 3 provided clear evidence that receptor-bound prorenin gains 'renin activity' without undergoing the proteolytic cleavage of the prosegment of prorenin as a result of a conformational change, although the enzymatic activity of receptor-bound renin is similar to that of free renin. On the basis of these findings, renin may be an endogenous inhibitor for the binding of prorenin to the (P)RR.Stimulation of the (P)RR by renin and prorenin reportedly results in the activation of intracellular signaling pathways, including MAP kinases, in mesangial cells, 4-6 vascular smooth muscle cells, 7 cardiomyocytes 8 and renal tubular epithelial cells. 9 However, the significance of the (P)RR-dependent intracellular signals in vivo remains undetermined. SUGGESTIONS FROM ANIMAL MODELS OF DIAB...

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(Pro)renin Receptor Blockade Ameliorates Cardiac Injury and Remodeling and Improves Function After Myocardial Infarction

Ellmers

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Charles

et al. 2016

Journal of Cardiac Failure

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Association of (Pro)renin Receptor mRNA Expression with Angiotensin-Converting Enzyme mRNA Expression in Human Artery

Cited by 11 publications

References 69 publications

The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients

Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings

(Pro)renin Receptor Blockade Ameliorates Cardiac Injury and Remodeling and Improves Function After Myocardial Infarction

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