Association of proangiogenic and profibrotic serum markers with lung function and quality of life in sarcoidosis

Biener, Leonie; Kruse, Judith; Tuleta, Izabela; Pizarro, Carmen; Kreuter, Michael; Birring, S S; Nickenig, Georg; Skowasch, Dirk

doi:10.1371/journal.pone.0247197

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Another non-canonical observation was that all cardiac endothelial cells upregulated tissue remodeling pathways, such as TGFβ and ECM signaling, relative to control. This is certainly not a novel thought as many studies have showed that endothelial cells can have pro-fibrotic functions (53), but this suggests that histological fibrosis reported in CS might be the result of the concerted action of fibroblasts and endothelial cells. Thus, we show that cardiac endothelial cells exhibit upregulated angiogenic and pro-inflammatory phenotypes in CS relative to control.…”

Section: Discussionmentioning

confidence: 97%

Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets

Daoud

Lema

Won

et al. 2023

Front. Cardiovasc. Med.

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IntroductionCardiac presentation of autoimmune sarcoidosis, known as cardiac sarcoidosis (CS), is a poorly understood disease with high mortality and low diagnosis rate. While CS is an immunological syndrome, little is known about how cardiac parenchymal and stromal cells mediate its pathogenesis. Moreover, while most current sarcoidosis research is based on research in pulmonary sarcoidosis (PS), it remains unclear how much both presentations of sarcoidosis overlap. To tackle these concerns, we leveraged publicly available sarcoidosis transcriptomic datasets.MethodsTwo publicly available bronchoalveolar lavage single-cell RNA sequencing datasets were integrated to analyze PS relative to control. Additionally, two publicly available cardiac single-nucleus RNA sequencing datasets were integrated to analyze CS relative to control. Following integration, we ran cell-cell communication, transcription factor, and differential expression analyses on parenchymal, stromal, and immune subsets identified in our analysis.ResultsOur analysis revealed that there was an expansion of stromal and immune cells in PS and CS. We also observed upregulation of Th17.1 and attenuated activation transcriptional profiles in the immune cells of CS and PS relative to control. Additionally, we found upregulation of pro-inflammatory and pro-fibrotic transcriptional profiles in the cardiac stromal cells of CS relative to control. We also found that cardiomyocytes exhibited upregulated cardiac stress and proliferation transcriptional profiles in CS relative to control.ConclusionsOur integrative transcriptomic analysis shows that despite tissue-specific differences, there are shared transcriptional trends between CS and PS. It also shows that stromal and parenchymal populations exhibit transcriptional trends that could explain their pathogenic role in CS.

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Section: Discussionmentioning

confidence: 97%

Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets

Daoud

Lema

Won

et al. 2023

Front. Cardiovasc. Med.

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“…PDGF-AB was associated with decreased health-related QoL. These mediators may represent a prognostic and therapeutic target for sarcoidosis as a brotic lung disease beyond IPF [115].…”

Section: The Hotspots and Frontiersmentioning

confidence: 89%

Bibliometric and Visual Analysis of Fibrotic Pulmonary Sarcoidosis

WEI,

Fang,

Zhao

et al. 2024

Preprint

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Background Fibrotic pulmonary sarcoidosis (FPS) has a high mortality rate, but its pathogenesis is not clear and effective treatments are lackings. In recent years, numerous literature reviews have been published from various perspectives on FPS. However, there is still a lack of visual analysis and summary of its research status, hotspots, and development trends. Therefore, to fill this knowledge gap, this study conducted a bibliometric and visual analysis of the published literature on FPS. Methods A total of 962 relevant publications were extracted from the Web of Science Core Collection. CiteSpace was used to conduct a bibliometric analysis and draw knowledge maps from five dimensions: publication years and document types, scientific collaboration networks (authors, countries/territories and institutions), journals, references and keywords. Results Current FPS research exhibits steady growth, capturing widespread attention. Noteworthy authors include Bargagli E, Baughman RP, Valeyre D, Raghu G, and Hunninghake GW. USA, Italy, Germany, England, and Netherlands demonstrate relatively mature research in this field. Three influential research institutions, namely Royal Brompton Hospital (England), Imperial College London (England) and University of California System (USA), stand out in this field. Important journals include American Journal of Respiratory and Critical Care Medicine, European Respiratory Journal, Chest, Thorax and Respiratory Medicine. These journals primarily focus on the evaluation, clinical and immunological characteristics, and treatment of FPS. Current hot research topics mainly include FPS-relevant diseases (interstitial lung disease, idiopathic pulmonary fibrosis and pulmonary fibrosis), complications (pulmonary hypertension, chronic obstructive pulmonary disease, and lung cancer), commonly used treatments (bronchoalveolar lavage), and biomarkers (YKL-40). Diagnosis, treatment (clinical trial drug studies), cardiac sarcoidosis, and quality of life are currently in an explosive stage and will be the focus of future research. Conclusion This research provides useful information for the study of FPS, including potential collaborators, research status of various countries and institutions, distribution and knowledge structure of journals, as well as research status and hotspots, providing a reference for future broader and deeper research.

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“…In a separate study involving 54 patients, an association was found between lung function and serum levels of PDGF-AB and VEGF in individuals with sarcoidosis. However, VEGF concentrations did not differ significantly among patients with sarcoidosis, idiopathic pulmonary fibrosis (IPF), or controls [92]. An investigation into B cell-activating factors (BAFFs) in plasma levels conducted on 55 sarcoidosis patients revealed the following (90).…”

Section: Serum Biomarkersmentioning

confidence: 99%

Phenotypes and Serum Biomarkers in Sarcoidosis

Della Zoppa,

Bertuccio,

Campo

et al. 2024

Diagnostics

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Sarcoidosis is a multisystem disease, which is diagnosed on a compatible clinical presentation, non-necrotizing granulomatous inflammation in one or more tissue samples, and exclusion of alternative causes of granulomatous disease. Considering its heterogeneity, numerous aspects of the disease remain to be elucidated. In this context, the identification and integration of biomarkers may hold significance in clinical practice, aiding in appropriate selection of patients for targeted clinical trials. This work aims to discuss and analyze how validated biomarkers are currently integrated in disease category definitions. Future studies are mandatory to unravel the diverse contributions of genetics, socioeconomic status, environmental exposures, and other sociodemographic variables to disease severity and phenotypic presentation. Furthermore, the implementation of transcriptomics, multidisciplinary approaches, and consideration of patients’ perspectives, reporting innovative insights, could be pivotal for a better understanding of disease pathogenesis and the optimization of clinical assistance.

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Association of proangiogenic and profibrotic serum markers with lung function and quality of life in sarcoidosis

Cited by 5 publications

References 23 publications

Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets

Integrative single-cell analysis of cardiac and pulmonary sarcoidosis using publicly available cardiac and bronchoalveolar lavage fluid sequencing datasets

Bibliometric and Visual Analysis of Fibrotic Pulmonary Sarcoidosis

Phenotypes and Serum Biomarkers in Sarcoidosis

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