Association of Psychiatric Disorders and Sleep Apnea in a Large Cohort

Sharafkhaneh, Amir; Giray, Nilgun; Richardson, Peter; Young, Terry; Hirshkowitz, Max

doi:10.1093/sleep/28.11.1405

Cited by 404 publications

(290 citation statements)

References 42 publications

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“…To the best of this author's knowledge there is not currently evidence available from large community samples that indicate whether the relationship between sleep apnea and anxiety disorders is greater than would be expected by random association. An analysis from the large Veteran's Administration Healthcare data base, however, did indicate an increased association of diagnoses of "anxiety" and PTSD (as well as other psychiatric disorders) with sleep apnea (60).…”

Section: Sleep Anxiety Symptoms and Sleep Apneamentioning

confidence: 87%

Sleep and Anxiety Disorders

Mellman

2008

Sleep Medicine Clinics

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Section: Sleep Anxiety Symptoms and Sleep Apneamentioning

confidence: 87%

Sleep and Anxiety Disorders

Mellman

2008

Sleep Medicine Clinics

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“…One important line of research builds upon findings from several large-scale epidemiological studies, which have demonstrated that approximately 20% of depressed patients exhibit a frequently undiagnosed sleep-disordered breathing, mostly obstructive sleep apnea [28,29]. This goes in line with a large number of reports which have gathered data linking metabolic syndrome and, most importantly, obesity and diabetes or insulin resistance, together with elevated inflammatory markers, to both sleep-disordered breathing and depression [30][31][32][33][34][35][36].…”

Section: Eds and Depressionmentioning

confidence: 89%

Chronobiology, excessive daytime sleepiness and depression: Is there a link?

2009

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The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical practice, may arise from a variety of psychiatric disorders, most importantly depression. Even though EDS frequently leads depressed patients to seek medical assistance, it is commonly under-evaluated and under-diagnosed. Therefore, a comprehensive understanding and management of EDS is essential in the clinical assessment of depression. Within a theoretical framework, a chronobiological approach may shed new light on the complex interaction of EDS and depression. In this review, studies on EDS and depression are summarized and discussed within the context of circadian and sleep regulatory mechanisms. Furthermore, potential chronobiological therapeutic strategies are proposed to address some of the unmet needs in the treatment of EDS and depression.

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“…6 In patients with a sleep disorder, the prevalence of depression has been reported to be 17.6% 7 ; in patients with OSA in particular, its prevalence is even higher, ranging from approximately 20% to 40% when assessed using the Beck Depression Inventory. 5,8,9 Progression of OSA has been found to be associated with an increased risk of developing depression. 10 Even patients with mild OSA are 60% more likely to become depressed than individuals without this sleep disorder.…”

Section: Depression In Patients With Osamentioning

confidence: 99%

“…In a study of a large cohort of nearly 120,000 veterans treated in US hospitals, anxiety, posttraumatic stress disorder, and psychosis were found in significantly more patients with OSA than in patients who did not have this sleep disorder (16.7%, 11.9%, and 5.1%, respectively; P < .0001). 5 The aims of this review are to examine the relationship between OSA and depression and also to describe how OSA and ES can be recognized in the primary care setting. The role of the primary care physician (PCP) in supporting, monitoring, and educating patients during treatment for OSA will also be discussed.…”

mentioning

confidence: 99%

Recognizing and Managing Obstructive Sleep Apnea in Primary Care

Culpepper¹,

Roth²

2009

Prim. Care Companion J. Clin. Psychiatry

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Objective: This review aims to impart information regarding recognition of obstructive sleep apnea (OSA) and associated excessive sleepiness (ES) in the primary care setting in order to provide optimal care to patients with this common but serious condition. This review will also discuss the prevalence and treatment of depression in patients with OSA.Data Sources: A MEDLINE search of articles published between 1990 and 2008 was conducted using the search terms obstructive sleep apnea AND excessive sleepiness, obstructive sleep apnea AND depression, and obstructive sleep apnea AND primary care. Searches were limited to articles in English concerned with adult patients.Study Selection: In total, 239 articles were identified. Articles concerning other sleep disorders and forms of apnea were excluded. The reference lists of identified articles were searched manually to find additional articles of interest.Data Synthesis: Primary care physicians can aid in the diagnosis of OSA and associated ES by being vigilant for lifestyle and physical risk factors associated with this condition. In addition, primary care physicians should maintain a high level of clinical suspicion when presented with illnesses that are commonly comorbid with OSA, such as psychiatric disorders and depression, in particular. Conversely, assessment of patients with OSA for common comorbidities may also improve a patient's prognosis and quality of life.Conclusions: Primary care physicians play a vital role in recognizing OSA and ES. These clinicians are crucial in supporting their patients during treatment by ensuring that they have clear, concise information regarding available therapies and the correct application and maintenance of prescribed devices.

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Association of Psychiatric Disorders and Sleep Apnea in a Large Cohort

Cited by 404 publications

References 42 publications

Sleep and Anxiety Disorders

Sleep and Anxiety Disorders

Chronobiology, excessive daytime sleepiness and depression: Is there a link?

Recognizing and Managing Obstructive Sleep Apnea in Primary Care

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