Association of psychotropic drug use with falls among older adults in Germany. Results of the German Health Interview and Examination Survey for Adults 2008 – 2011 (DEGS1)

Du, Yong; Wolf, IK; Knopf, Hildtraud

doi:10.1055/s-0037-1606014

Cited by 2 publications

(6 citation statements)

References 34 publications

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“…The use of psychoactive medicines would increase 1.79 times of the risk of falls higher than patients who did not use (95% CI 1.10-2.90). These results were consistent to previous studies (Bloch et al, 2011;Du et al, 2017;Mustafidah, 2019). A Study conducted in Germany elderly population in 2008-201 revealed that psychoactive drug use was associated with falls in the elderly with OR 1.64 (95% CI 1.14-2.37) (Du et al, 2017).…”

Section: Association Psychoactive Drugs Use and Fall Risksupporting

confidence: 94%

“…The use of psychoactive medicines in the case group was statistically and significantly higher than that in the control group (31.16% vs 21.38%, p<0.05) (Table III). This is consistent with the finding of the previous study in Germany revealing that the elderly with fall had higher psychoactive drugs use (33.1% vs. 20.7%) (Du et al, 2017). The characteristics of psychoactive medicines evaluated in the study were duration of drug use, the number of psychoactive drugs, and The Standardized Daily Dose (SDD).…”

Section: Volume 30 Issue 3 (2019)supporting

confidence: 91%

“…In addition, the elderly patient had increased blood-brain barrier permeability and receptor sensitivity to psychoactive medicines (Lee et al, 2016). The previous study in Germany revealed that psychoactive drug use was associated with falls in the elderly with OR 1.64 (95% CI 1.14-2.37) (Du et al, 2017). Another study updated meta-analysis study of psychoactive drugs use and falls in the elderly with OR 1.78 (95% CI 1.57-2.01) (Bloch et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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A Study of Psychoactive Medicines and Risk of Falls Among Indonesian Elderly Patients

Rahmawati

Mustafidah

Pramantara

et al. 2019

Indonesian J. Pharm.

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One of the causes of injury to the elderly is due to falls. Falling can be prevented by identifying and controlling risk factors. One risk factor that can be controlled is the use of fall risk medicines including psychoactive. This study aims to identify the association between the use of psychoactive medicine and its characteristic with the risk of falls among the elderly in Indonesia. The study utilized a case-control study design for a total number of 414 elderly patients, during October until December 2018. Cases were elderly aged 60 years or above with a high risk of falling assessed using the Morse Fall Scale (MFS≥45). Each case was matched with up to two randomly selected controls of the same age who are classified as low to moderate risk of falling (MFS<45). The use of psychoactive medicines was screened from a history of drug use for the past six months. Psychoactive medicine-fall risk associations were estimated via logistic regression. There were 138 cases and 276 controls. The median age of subjects was 66 years old and 54.83% was a woman. Elderly with a high risk of falling had higher psychoactive medicines use when compare with controls (31.16 % vs 21.38 %, p< 0.05). After adjusting for potential confounders, the use of psychoactive medicines was significantly associated with higher fall risk in elderly patients (OR 1.79 95% CI 1.10-2.90). Only the duration of psychoactive medication use over 90 days was significantly associated with a high risk of falling (AOR 3.65 95% CI 1.46-9.14). In elderly patients, the continued use of psychoactive medicines increased the risk of fall. Prescribers need to weigh risk and benefit from the use of psychoactive medicines in the elderly to prevent future fall.

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Section: Association Psychoactive Drugs Use and Fall Risksupporting

confidence: 94%

Section: Volume 30 Issue 3 (2019)supporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

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A Study of Psychoactive Medicines and Risk of Falls Among Indonesian Elderly Patients

Rahmawati

Mustafidah

Pramantara

et al. 2019

Indonesian J. Pharm.

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“…A retrospective cohort study of 73690 community-dwelling veterans found that patient on one or more psychoactive drug or increased dosage of that were observed to have a significantly increased fall risk [12]. Using data of German Health Interview and Examination Survey for Adults 2008-2011, an epidemiological study found that self-reported psy- choactive drugs were overall associated with 64% increase in the risk of falls and recurrent falls on self-report in the past 12 months in community-dwelling older adults aged 65-79 years [10]. A prospective cohort of 1759 community-dwelling healthy older adults followed up for 12 months by telephone showed a 90% higher fall risk among psychoactive drug users [9].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are many studies about the relationships between psychoactive drug use and falls in community-dwelling older people [6][7][8][9][10][11][12][13]; however, this relationship has not been examined enough in outpatients in Turkey. Older outpatients with severe health problems, multi-morbidities, and complicated diseases are at high risk of fall.…”

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confidence: 99%

Psychoactive Drug Use and Falls among Community-Dwelling Turkish Older People

Naharcı

Oguz

Celebi

et al. 2019

North Clin Istanbul

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F alls are a significant common problem in older adults, reducing function and quality of life, increasing the risk for fear of falling syndrome, and causing morbidity and mortality. One-third of community-dwelling people aged over 65 years fall one or more times each year and repeated falls occur in half of them [1]. Brain trauma, hip fractures, hospitalization and death are worst outcomes of falls. Accidents are the seventh cause of deaths in older people and the majority are associated with falls [2]. Most falls arise from one or more combination risk factors, including advanced age, impaired cognitive function, comorbidities, sensory factors and environmental hazards. Drugs are another major modifiable risk factor for falls. Of those, psychoactive drugs are the most common cause associated with falls, with sedation, impaired balance, and coordination that result in gait problems. Psychoac-ABSTRACT OBJECTIVE: Data on the relationship between fall and psychoactive drug use among Turkish older people are limited. This study aims to investigate the prevalence of falls and the associations between psychoactive drug use and falls in communitydwelling Turkish older people. METHODS: This single center study was performed using the medical records of subjects aged over 65 years admitted to the geriatric care unit. Demographic and lifestyle factors, clinical characteristics, medications, and data on mood, cognitive status, and functional performance were obtained from the comprehensive geriatric assessment records. Based on a fall history in the last 12 months, subjects were grouped as fallers and non-fallers. Subjects treated with a psychoactive drug were identified. RESULTS: Among the total of 429 subjects, there were 184 (42.9%) fallers and 245 (57.1%) non-fallers. Of those, 33.3% were on psychoactive drug treatment. The proportion of psychoactive drug users was higher in the fallers group compared to non-fallers (45.1% vs. 24.5%, p<0.001). Multivariable logistic regression analysis showed age ≥75 years (OR=1.83; CI: 1.09-3.09; p=0.023), female gender (OR=2.70; CI: 1.6-4.50; p<0.001), and psychoactive drug use (OR=2.14; CI: 1.32-3.48; p=0.002) as independent predictors of falls. CONCLUSION: We found that about one-third of geriatric outpatients were on psychoactive drug treatment in Turkey that was independently associated with the risk of falls.

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Association of psychotropic drug use with falls among older adults in Germany. Results of the German Health Interview and Examination Survey for Adults 2008 – 2011 (DEGS1)

Cited by 2 publications

References 34 publications

A Study of Psychoactive Medicines and Risk of Falls Among Indonesian Elderly Patients

A Study of Psychoactive Medicines and Risk of Falls Among Indonesian Elderly Patients

Psychoactive Drug Use and Falls among Community-Dwelling Turkish Older People

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