Association of PTEN genetic polymorphisms with atherosclerotic cerebral infarction in the Han Chinese population

Association between Phosphatase Related Gene Variants and Coronary Artery Disease: Case-Control Study and Meta-Analysis

“…Recent study [41] revealed that serum alkaline phosphatase is an independent predictor of mortality, myocardial infarction, or stent thrombosis in CAD patients after percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). In addition to the three genes studied in this work, there are other phosphatase related genes implicated in CAD, for instance, the polymorphisms of phosphatase and tensin homologue ( PTEN ) gene are significantly associated with atherosclerotic cerebral infarction (ACI) in the Chinese population [42]. Genetic polymorphisms of the protein tyrosine phosphatase non-receptor 22 (PTPN22) are reported to be involved in atherosclerosis and played a role in the immune response involved in the pathogenesis of CAD [43,44].…”

Association studies of candidate single-nucleotide polymorphisms with Symptomatic Intracranial Atherosclerotic Stenosis in a Chinese Han population

“…Data were collected through case report forms. Ischemic stroke was confirmed by CT and/or MRI as we described before [24][25][26]. All patients had undergone the evaluation of cerebral vascular via MRA/CTA/DSA/ CE-MRA or transcranial Doppler (TCD) or carotid color duplex ultrasonography.…”

“…Concentrations of glucose, total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), blood urea nitrogen(BUN), creatinine(Cr), uric acid(UA) and glycated hemoglobin HbA1C were measured according to our laboratory protocols. Hypertension, diabetes mellitus, and dyslipidemia were defined as we published before [24][25][26].…”

Phosphatase and Tensin Homologue Genetic Polymorphisms and their Interactions with Viral Mutations on the Risk of Hepatocellular Carcinoma

“…The SNPs in the intron (rs1234213, rs1234220, rs2299939, rs532678, rs1234219, rs12572106, and rs2299941), at intron/exon boundaries (rs1903858), and in the 3’UTR (rs701848) were selected based on the HapMap screening and previous literatures regarding the associations of PTEN SNPs with cancers or inflammation-related diseases. [ 27 28 29 ] We excluded SNPs if they were monomorphic or had low frequencies in our samples (rs12572106, rs1234219, and rs701848) or their surrounding sequences were not suitable for designing the minor groove binder (MGB) probes (rs532678, rs2299941, and rs1903858). Three intronic SNPs rs1234220 (T>C, in the intron 3), rs2299939 (G>T, in the intron 5), and rs1234213 (C>T, in the intron 7) were finally selected in this study.…”