Association of pulse wave velocity and pressure wave reflection with the ankle-brachial pressure index in Japanese men not suffering from peripheral artery disease

Takahashi, Takamichi; Tomiyama, Hirofumi; Aboyans, Victor; Kumai, Kento; Nakano, Hiroki; Fujii, Masatsune; Shiina, Kazuki; Matsumoto, Chisa; Yamashina, Akira; Chikamori, Taishiro

doi:10.1016/j.atherosclerosis.2020.11.031

Cited by 11 publications

(13 citation statements)

References 34 publications

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“…abnormal wave reflection) could additively contribute to the onset of hypertension [ 23 , 24 ]. It is possible that the crosstalk between micro-circulation and macro-circulation and the inter-connection between them leads to additive detrimental effects on the circulation due to increased global vascular stiffness [ 25 , 26 ]. There are limited reports on the direct relationship between the changes in vascular elasticity due to high sodium intake in both males and females.…”

Section: Introductionmentioning

confidence: 99%

Differential biomechanics in resistance arteries of male compared with female Dahl hypertensive rats

Mensah¹,

Daneshtalab

Tabrizchi³

2021

Journal of Hypertension

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Background: Increase in vascular stiffness is associated with a higher risk of cardiovascular morbidity and mortality and is likely sex-specific. Method: Our objectives were to compare structural and functional alterations in small resistance arteries as related to vascular stiffness from Dahl salt-sensitive male and female rats ( n = 8, mean ± s.e.m.). Results: Arterial blood pressure and pulse wave velocity were significantly ( P < 0.05) elevated in males (161 ± 3 mmHg; 6.4 ± 0.2 m/s) and females (147 ± 2 mmHg; 5.5 ± 0.1 m/s) on a high (H) salt compared with regular (R) diets but were significantly higher in males (H) than in all others. Significant increases in collagen and smooth muscle cell areas were evident in ultrastructure of mesenteric arteries of hypertensive males compared to normotensive or corresponding females. There were no significant differences in composite Young's modulus (CYM) between groups. Vasoconstriction resulted in significantly higher CYM in male (H: 8.6 ± 1 KPa) than R (4.5 ± 0.8 KPa), and the corresponding females (H: 5.6 ± 0.6 KPa and R: 5 ± 0.9 KPa). In contrast, vasodilation significantly reduced CYM in the male groups (H: 2.5 ± 0.4 KPa and R: 2.7 ± 0.5 KPa) compared with the corresponding values in females (H: 4.2 ± 0.6 KPa and R: 5 ± 0.5 KPa). Moreover, the slope of pressure-volume curves revealed significantly greater distended vascular compliance in male H than R, and the corresponding females. Conclusion: Our findings are supportive of a link between high salt intake and elevated blood pressure as being sex specific, likely involving sex-dependent changes in ultrastructure of the vessels, which ultimately may alter the biomechanics, and thus, the haemodynamic functions of both macro-circulation and micro-circulations.

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Section: Introductionmentioning

confidence: 99%

Differential biomechanics in resistance arteries of male compared with female Dahl hypertensive rats

Mensah¹,

Daneshtalab

Tabrizchi³

2021

Journal of Hypertension

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“… 35 On the contrary, a study in middle-aged Japanese men free of PAD reported that decreased AS is related to lower ABI. 19 This could be explained by the fact that AS (eg, baPWV) reflects the stiffening of central and peripheral muscular arteries, 36 which is closely correlated with but different from blood pressure. Central vascular stiffening as a dominant component of baPWV is a strong predictor of cardiovascular diseases and PAD.…”

Section: Discussionmentioning

confidence: 99%

“…After the patient lay supine for 5 minutes, 4 cuffs were placed on the bilateral brachial and ankle joints, and then the plethysmographic sensor and the oscilloscope pressure sensor were connected, and the maximum value of baPWV on the left and right sides was selected as the systemic AS level, as previously described. 18 , 19 Normal AS was defined as baPWV <1,400 cm/s and elevated AS as baPWV ≥1,400 cm/s. In addition, we also classified baPWV into 3 categories: normal AS was defined as baPWV <1,400 cm/s, moderately elevated AS as 1,400 ≤ baPWV <1,800 cm/s, and severely elevated AS as baPWV ≥1,800 cm/s according to previous standards.…”

Section: Methodsmentioning

confidence: 99%

Combined Evaluation of Arterial Stiffness and Blood Pressure Promotes Risk Stratification of Peripheral Arterial Disease

Jiang

Zhu

et al. 2023

JACC: Asia

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“…Pulse wave velocity (PWV) is a recognized marker of large artery stiffness and adverse cardiovascular outcomes [11]. Previous studies have found that PWV is directly associated with higher ankle-brachial index values in individuals without peripheral artery disease [12], suggesting that leg BP may be a more sensitive marker of increased arterial stiffness than arm BP. However, it is still unclear whether arm and leg BP measurements have distinct abilities to predict abnormal arterial stiffness, and the impact of postural changes on this relationship is not well established.…”

Section: Introductionmentioning

confidence: 99%

Relationship of blood pressure measured in the calf with arm blood pressure and arterial stiffness: a general population study

Marques,

Bernardino,

Alvim

et al. 2023

Journal of Hypertension

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Aim: Leg blood pressure (BP) measurement is needed when arm BP evaluation is not feasible, and calf BP, especially when measured in standing position, may have greater association with cardiovascular remodeling than arm BP. This study evaluated the relationship between calf and arm BP, and investigated whether calf BP would be superior to arm BP in predicting increased arterial stiffness [pulse wave velocity (PWV) > 10 m/s]. Methods: We evaluated clinical and laboratory characteristics, BP measurements, and PWV in 1397 individuals resident in Baependi, Brazil, between 2017 and 2019. Arm BP was measured in the seated and supine positions while calf BP was measured in supine and standing positions using digital oscillometric devices. Carotid–femoral PWV was measured using a noninvasive mechanotransducer. Results: The sample had 62.7% females, age = 48.1 ± 15.4 years and 8.4% with PWV >10 m/s. Results of linear regression analysis showed that BP values of 140/90 mmHg measured in the arm in supine and seated position were equivalent to calf supine BP values of 164/81 mmHg and 166/78 mmHg and calf standing BP values of 217/137 mmHg and 221/137 mmHg, respectively. Calf-arm BP differences were associated with age, glomerular filtration rate, body mass index, smoking, low-density lipoprotein-cholesterol, diabetes and height. Furthermore, stepwise logistic regression analysis revealed that arm supine systolic BP, but not calf BP measurements, was independently associated with increased arterial stiffness. Conclusion: Thresholds of ≈165/80 mmHg and ≈220/135 mmHg could be used for diagnosing hypertension when only calf measurements in supine and standing positions, respectively, are available. Conversely, calf BP was not superior to arm BP in predicting increased arterial stiffness.

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Association of pulse wave velocity and pressure wave reflection with the ankle-brachial pressure index in Japanese men not suffering from peripheral artery disease

Cited by 11 publications

References 34 publications

Differential biomechanics in resistance arteries of male compared with female Dahl hypertensive rats

Differential biomechanics in resistance arteries of male compared with female Dahl hypertensive rats

Combined Evaluation of Arterial Stiffness and Blood Pressure Promotes Risk Stratification of Peripheral Arterial Disease

Relationship of blood pressure measured in the calf with arm blood pressure and arterial stiffness: a general population study

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