Association of recent exposure to ambient metals on fractional exhaled nitric oxide in 9–11year old inner-city children

Rosa, Maria José; Perzanowski, Matthew S.; Divjan, Adnan; Chillrud, Steven N.; Hoepner, Lori; Zhang, Hanjie; Ridder, Robert; Perera, Frederica P.; Miller, Rachel L.

doi:10.1016/j.niox.2014.05.008

Cited by 18 publications

(17 citation statements)

References 59 publications

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“…We observed enhanced FeNO with exposure to PM 2.5 characterized by increased glutathione-related oxidative burden for children with allergies to mold, fur, or dust. Suggestions of enhanced exacerbations of asthmatic symptoms in children exposed to traffic-related pollutants and allergens have been reported previously for exposures to nitrogen dioxide ( Dell et al 2014 ), black carbon ( Cornell et al 2012 ), formaldehyde and acetaldehyde ( Flamant-Hulin et al 2009 ), as well as trace metals (nickel from residential oil heating) ( Rosa et al 2014 ). Ours is the first report to show that the effects of pro-oxidant exposure, quantified by oxidative burden, may be modified by the presence of allergic disease, although we must emphasize that there was no clear signal in these interaction analyses.…”

Section: Discussionmentioning

confidence: 85%

Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma

Maikawa

Weichenthal

Wheeler

et al. 2016

Environ Health Perspect

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Background:Epidemiological studies have provided strong evidence that fine particulate matter (PM2.5; aerodynamic diameter ≤ 2.5 μm) can exacerbate asthmatic symptoms in children. Pro-oxidant components of PM2.5 are capable of directly generating reactive oxygen species. Oxidative burden is used to describe the capacity of PM2.5 to generate reactive oxygen species in the lung.Objective:In this study we investigated the association between airway inflammation in asthmatic children and oxidative burden of PM2.5 personal exposure.Methods:Daily PM2.5 personal exposure samples (n = 249) of 62 asthmatic school-aged children in Montreal were collected over 10 consecutive days. The oxidative burden of PM2.5 samples was determined in vitro as the depletion of low-molecular-weight antioxidants (ascorbate and glutathione) from a synthetic model of the fluid lining the respiratory tract. Airway inflammation was measured daily as fractional exhaled nitric oxide (FeNO).Results:A positive association was identified between FeNO and glutathione-related oxidative burden exposure in the previous 24 hr (6.0% increase per interquartile range change in glutathione). Glutathione-related oxidative burden was further found to be positively associated with FeNO over 1-day lag and 2-day lag periods. Results further demonstrate that corticosteroid use may reduce the FeNO response to elevated glutathione-related oxidative burden exposure (no use, 15.8%; irregular use, 3.8%), whereas mold (22.1%), dust (10.6%), or fur (13.1%) allergies may increase FeNO in children with versus children without these allergies (11.5%). No association was found between PM2.5 mass or ascorbate-related oxidative burden and FeNO levels.Conclusions:Exposure to PM2.5 with elevated glutathione-related oxidative burden was associated with increased FeNO.Citation:Maikawa CL, Weichenthal S, Wheeler AJ, Dobbin NA, Smargiassi A, Evans G, Liu L, Goldberg MS, Godri Pollitt KJ. 2016. Particulate oxidative burden as a predictor of exhaled nitric oxide in children with asthma. Environ Health Perspect 124:1616–1622; http://dx.doi.org/10.1289/EHP175

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Section: Discussionmentioning

confidence: 85%

Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma

Maikawa

Weichenthal

Wheeler

et al. 2016

Environ Health Perspect

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“…Cohort studies have suggested that acute (e.g., same day) and subacute (e.g., cumulative over days to one week) exposures to BC may exacerbate respiratory symptoms and increase airway inflammation among urban children [ 2 – 4 ]. Others have identified short-term lag effects (e.g., up to 5 days) of measures of air pollution on airway-related outcomes [ 2 , 3 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

et al. 2017

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BackgroundAsthma gene DNA methylation may underlie the effects of air pollution on airway inflammation. However, the temporality and individual susceptibility to environmental epigenetic regulation of asthma has not been fully elucidated. Our objective was to determine the timeline of black carbon (BC) exposure, measured by personal sampling, on DNA methylation of allergic asthma genes 5 days later to capture usual weather variations and differences related to changes in behavior and activities. We also sought to determine how methylation may vary by seroatopy and cockroach sensitization and by elevated fractional exhaled nitric oxide (FeNO).MethodsPersonal BC levels were measured during two 24-h periods over a 6-day sampling period in 163 New York City children (age 9–14 years), repeated 6 months later. During home visits, buccal cells were collected as noninvasive surrogates for lower airway epithelial cells and FeNO measured as an indicator of airway inflammation. CpG promoter loci of allergic asthma genes (e.g., interleukin 4 (IL4), interferon gamma (IFNγ), inducible nitric oxide synthase (NOS2A)), arginase 2 (ARG2)) were pyrosequenced at the start and end of each sampling period.ResultsHigher levels of BC were associated with lower methylation of IL4 promoter CpG−48 5 days later. The magnitude of association between BC exposure and demethylation of IL4 CpG−48 and NOS2A CpG+5099 measured 5 days later appeared to be greater among seroatopic children, especially those sensitized to cockroach allergens (RR [95% CI] 0.55 [0.37–0.82] and 0.67 [0.45–0.98] for IL4 CpG−48 and NOS2A CpG+5099, respectively), compared to non-sensitized children (RR [95% CI] 0.87 [0.65–1.17] and 0.95 [0.69–1.33] for IL4 CpG−48 and NOS2A CpG+5099, respectively); however, the difference was not statistically different. In multivariable linear regression models, lower DNA methylation of IL4 CpG−48 and NOS2A CpG+5099 were associated with increased FeNO.ConclusionsOur results suggest that exposure to BC may exert asthma proinflammatory gene demethylation 5 days later that in turn may link to airway inflammation. Our results further suggest that seroatopic children, especially those sensitized to cockroach allergens, may be more susceptible to the effect of acute BC exposure on epigenetic changes.Electronic supplementary materialThe online version of this article (doi:10.1186/s13148-017-0361-3) contains supplementary material, which is available to authorized users.

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“…In a study conducted in Seattle, ambient particulate matter less than 2.5 μ m in diameter (PM 2.5 ) was found to be associated with exhaled NO in children with and without asthma [ 14 ]. A study conducted in healthy children aged 9–11 years in New York found a relationship between exposure to ambient metals and increased FeNO [ 4 ]. Another study performed at 25 schools in the Netherlands found a positive association between ambient PM 10 concentrations on the day exhaled NO was measured [ 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…e ., particulate matter, ambient NO, and carbon monoxide) or occupational exposure ( i . e ., organic solvents and heavy metals) [ 4 – 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Many studies have confirmed that the dust emitted in the production of iron and steel is an important source of ambient air particulate matter in some areas [ 10 ]. The smelting process in the iron and steel industry is known to be a major source of ambient nickel, iron, vanadium, lead, copper, and zinc, and an association between the airborne concentrations of nickel, vanadium, zinc, iron, and FeNO has been reported [ 4 ]. Another study showed that the concentrations of all measured heavy metals in an iron and steel industry zone were 1–3.5 times higher than those measured in other areas [ 10 ].…”

Section: Introductionmentioning

confidence: 99%

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Comparison of the Fractional Exhaled Nitric Oxide Levels in Adolescents at Three Schools Located Three Different Distances from a Large Steel Mill

Acat

Aydemir

Yazici

et al. 2017

Canadian Respiratory Journal

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Objectives. Exposure to ambient metals and air pollutants in urban environments has been associated with impaired lung health and inflammation in the lungs. Fractional exhaled nitric oxide (FeNO) is a reliable marker of airway inflammation. In this study, we aimed to compare the FeNO levels of three schools that have different distances from iron and steel industry zone for assessing the effects of heavy metals and air pollution on their respiratory health. Methods. Pulmonary function test and FeNO measurements were evaluated in 387 adolescents in three schools which have different distance from plant. Results. FeNO levels were significantly higher in School I (n = 142; 18.89 ± 12.3 ppb) and School II (n = 131; 17.68 ± 7.7 ppb) than School III (n = 114; 4.28 ± 3.9 ppb). Increased FeNO concentration was related to the distance of iron and steel industry zone in young adults. Conclusion. The FeNO concentrations in school children were inversely proportional to the distance from the steel mill. There are needed some studies that can evaluate the safe distance and legislation must consider these findings.

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Association of recent exposure to ambient metals on fractional exhaled nitric oxide in 9–11year old inner-city children

Cited by 18 publications

References 59 publications

Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma

Particulate Oxidative Burden as a Predictor of Exhaled Nitric Oxide in Children with Asthma

Effect of personal exposure to black carbon on changes in allergic asthma gene methylation measured 5 days later in urban children: importance of allergic sensitization

Comparison of the Fractional Exhaled Nitric Oxide Levels in Adolescents at Three Schools Located Three Different Distances from a Large Steel Mill

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