Association Of Recent Exposure To Ambient Metals On Fractional Exhaled Nitric Parameters In 9-11 Year Old Inner-City Children

Rosa, Maria José; Divjan, Adnan; Perzanowski, Matthew S.; Chillrud, Steven N.; Zhang, Hanjie; Ridder, Robert; Perera, Frederica P.; Miller, Rachel L.

doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5756

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Inhaled Ni may compete with the uptake of endogenous Fe, leading to elevated levels of available Fe and release of reactive oxygen species (ROS) [ 32 , 33 ]. Recent exposure to ambient metals has also been associated with increases in airway inflammation in inner-city children living in NYC [ 34 ]. Ni concentrations in particular were associated with increases in distal airway inflammation and such inflammation has been be associated airway hyper-responsiveness and symptom exacerbation [ 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Association between personal exposure to ambient metals and respiratory disease in Italian adolescents: a cross-sectional study

et al. 2016

View full text Add to dashboard Cite

Background: Release of ambient metals during ferroalloy production may be an important source of environmental exposure for nearby communities and exposure to these metals has been linked to adverse respiratory outcomes. We sought to characterize the association between personal air levels of metals and respiratory health in Italian adolescents living in communities with historic and current ferroalloy activity. Methods: As part of a study in the industrial province of Brescia, Italy, 410 adolescents aged 11-14 years were recruited. Participants were enrolled from three different communities with varying manganese (Mn) levels: Bagnolo Mella which has current ferroalloy activity, Valcamonica, which has historic ferroalloy activity and Garda Lake which has no history of ferroalloy activity. Particulate matter <10 μm in diameter (PM 10 ) was collected for 24 h in filters using personal sampling. Mn, nickel (Ni), zinc (Zn), chromium (Cr) and iron (Fe) were measured in filters using x-ray fluorescence. Data on respiratory health was collected through questionnaire. Data for 280 adolescents were analyzed using a modified Poisson regression, and risk ratios were calculated for an interquartile (IQR) range increase in each pollutant. Results: In adjusted models including PM 10 as a co-pollutant, we found significant associations between concentrations of Mn (RR: 1.09, 95 % CI [1.00,

show abstract