Association of Reflux With Otitis Media in Children

Lieu, Judith E. C.; Muthappan, Palaniappan; Uppaluri, Ravindra

doi:10.1016/j.otohns.2005.05.654

Cited by 67 publications

(97 citation statements)

References 19 publications

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“…And these findings are in agreement with a study that investigated the causal relationship of GERD and OME by confirming the finding of pepsin/pepsinogen in the middle ear fluid of children undergoing myringotomy and tube placement for chronic or recurrent OM , and querying parents about symptoms that suggest the presence of GERD in these children [11]. Our study reported that there were significant difference between group with pepsinogen in the middle ear and group without regarding GER disorders.…”

Section: /3supporting

confidence: 92%

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Pepsinogen Assay as a Marker of Reflux in Children with Otitis Media with Effusion

Abdelshafy¹

2015

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Section: /3supporting

confidence: 92%

“…The patients were chosen from outpatient clinic of Otorhinolaryngology, Menoufia University Hospital with mean age 6.44±1.72 years the minimum was 4 years and maximum was 9 years. Male represent 56% (14) of the studied group and female 44% (11). A written consent was taken from the parents of all patients.…”

Section: Methodsmentioning

confidence: 99%

Pepsinogen Assay as a Marker of Reflux in Children with Otitis Media with Effusion

Abdelshafy¹

2015

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“…Pepsinogen isoenzymes are found in the lung, pancreas, prostate, and some malignant tissues. Liu et al [18] found no pepsinogen 1 mRNA in infected mastoid mucosa by RT-PCR. Tasker et al [2] found no evidence of pepsinogen production by immunohistochemical methods in middle ear biopsy specimens.…”

Section: Correlation Among Pepsinogen Levels In Middle Ear Fluid and mentioning

confidence: 98%

“…Lieu et al [18] examined fluid samples obtained from 36 middle ears of 22 children. The samples were subjected to ELISA, and proteolytic activity was evaluated.…”

Section: Correlation Among Pepsinogen Levels In Middle Ear Fluid and mentioning

confidence: 99%

Role of Laryngopharyngeal Reflux in the Pathogenesis of Otitis Media with Effusion

Doğru

Kuran²,

Haytoğlu³

et al. 2015

Int Adv Otol

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OBJECTIVE:To determine whether there is an association between otitis media with effusion and laryngopharyngeal reflux in children. MATERIALS and METHODS:This study included 31 children with otitis media with effusion. The pepsinogen level in the middle ear fluid of all patients was measured by sandwich enzyme-linked immunosorbent assay. Each patient's middle ear fluid was investigated for Helicobacter pylori (H. pylori) using the Campylobacter-like organism (CLO) test. The middle ear pepsinogen levels were compared with those in the serum. The correlation between pepsinogen levels and H. pylori positivity in the middle ear fluid was investigated. RESULTS:The mean middle ear pepsinogen level (211.69 ng/mL) was significantly higher than that in the serum (24.18 ng/mL) in patients with otitis media with effusion. The middle ear aspirates of six patients (19%) were positive for H. pylori, and the correlation between H. pylori positivity and increased pepsinogen levels in the middle ear fluid was statistically significant in patients with otitis media with effusion. CONCLUSION:We detected higher pepsinogen levels and H. pylori positivity rates in the middle ear fluid than in the serum of patients with otitis media with effusion. These results support the role of laryngopharyngeal reflux in the pathogenesis of otitis media with effusion.

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Achados audiológicos e linguagem em gêmeas regurgitadoras

Andrade¹,

Pedruzzi

Soares

et al. 2009

Rev. CEFAC

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, Elizângela Dias Camboim (5) RESUMO Tema: achados audiológicos e linguagem em gêmeas regurgitadoras. Procedimentos: o estudo consiste no relato dos achados audiológicos e do desenvolvimento da linguagem de duas crianças, irmãs gêmeas regurgitadoras. Para isso, foram realizadas as seguintes etapas: coleta dos dados nos prontuários, relatórios das pacientes e coleta de informações com os familiares. Nos prontuários, além dos achados audiológicos e de linguagem, foi relatado também o tipo de abordagem terapêutica utilizada e os objetivos dos planejamentos diários que nortearam as sessões. Resultados: as crianças apresentaram ausência das emissões otoacústicas evocadas por estímulo transiente e produto de distorção, e potencial evocado auditivo de tronco encefálico via aérea e via óssea com limiar eletrofi siológico em 30 e 35dBNA bilateralmente, tendo sido sugerido no laudo perda auditiva de grau leve. No acompanhamento apresentaram episódios de otite média secretora, confi rmada pela avaliação otorrinolaringológica, e curvas timpanométricas do tipo B e C. As crianças iniciaram a terapia fonoaudiológica aos 10 meses de idade. Foram realizadas 32 sessões terapêuticas para o sujeito A.B. e 28 para o sujeito A.E., no período de 11 meses, nas quais as crianças demonstraram evolução, apresentando produções esperadas para a fase linguística do desenvolvimento da linguagem, porém não eram compatíveis com a idade observada na literatura estudada. Conclusão: as duas crianças com refl uxo gastroesofágico apresentaram perda condutiva, audição fl utuante nos primeiros dois anos de vida e atraso no desenvolvimento da linguagem. Apesar de suas produções apresentarem atraso, foi possível observar signifi cativa evolução das crianças em relação à aquisição de linguagem dentro do processo terapêutico. DESCRITORES:  INTRODUÇÃOA detecção da defi ciência auditiva deve ser realizada nos primeiros meses de vida. Portanto, os profi ssionais que intervêm no desenvolvimento infantil devem estar preparados para identifi car alterações da audição e encaminhar para avaliação auditiva. O ideal seria que todas as crianças fossem submetidas a uma avaliação audiológica no período neonatal, por meio de programas de triagem auditiva, pois uma surdez não identifi cada precocemente pode ter consequências devastadoras sobre o desenvolvimento da linguagem da criança 1,2 .As técnicas mais empregadas para triagem auditiva neonatal são: as emissões otoacústicas evocadas por estímulo transiente (EOAT), o potencial evocado auditivo de tronco encefálico (PEATE).

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Association of Reflux With Otitis Media in Children

Abstract: We replicated the finding of pepsin/pepsinogen in middle ear fluid of children with OME or ROM, but did not find any increase in GER symptoms. Further research is needed to establish a causative link between GER and OM.

Cited by 67 publications

References 19 publications

Pepsinogen Assay as a Marker of Reflux in Children with Otitis Media with Effusion

Pepsinogen Assay as a Marker of Reflux in Children with Otitis Media with Effusion

Role of Laryngopharyngeal Reflux in the Pathogenesis of Otitis Media with Effusion

Achados audiológicos e linguagem em gêmeas regurgitadoras

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