Association of Retinol-Binding Protein-4 (RBP4) with Lipid Parameters in Obese Women

Broch, Montserrat; Gómez, José Manuel; Auguet, Teresa; Vilarrasa, Núria; Pastor, Rosa María Ayela; Elío, Iñaki; Olona, Montserrat; Garcı́a-España, Antonio; Richart, C

doi:10.1007/s11695-010-0200-5

Cited by 44 publications

(36 citation statements)

References 42 publications

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“…In this study, the serum RBP4 levels showed an increase, which was not significant, in the obese groups as also observed by Shim et al (24). Further, there was no correlation, in any of the groups, between RBP4 and the parameters of inflammation, like Hs-CRP, as also reported by Broch et al (25). Ba la gopal et al (26) have reported a positive correlation between RBP4 and Hs-CRP in a small group of ado lescents, whereas Takebayashi et al (27) did not ob serve any correlation in the two parameters in hospitalised type 2 diabetes patients.…”

Section: Discussionsupporting

confidence: 82%

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

Shivakumar¹,

Kumar²,

Aswathanarayan³

et al. 2012

Journal of Medical Biochemistry

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List of abbreviations: BMI = body mass index; CVD = cardio vascular disorders; DBP = diastolic blood pressure; FBS = fasting blood sugar; HDL-C = HDL-cholesterol; HC = hip circumference; HOMA-IR = homeostasis model assessment of insulin resistance; Hs-CRP = high sensitivity C-reactive protein; ICO = index of central obesity; IDF = International Diabetes Federation; IR = insulin resistance; MS = metabolic syndrome; QUICKI = quantitative insulin sensitivity check index; RBP4 = retinol binding protein 4; SBP = systo lic blood pressure; TC = total cholesterol; TG = triglycerides; VLDL-C = VLDL-cholesterol; WC = waist circumference; WHR = waist: hip ratio.Summary: Retinol-binding protein 4 is an adipocytokine sep a rately implicated in the development of obesity-related insulin resistance and proatherogenic lipid profile, however, its role in humans is unclear. This study was carried out to assess the role of retinol-binding protein 4 as a potential marker of metabolic syndrome in obese Asian Indians (a high-risk population for diabetes). 52 obese (BMI >23 kg/m 2 ) Asian Indians were grouped into those with and without metabolic syndrome based on IDF criteria and compared with healthy controls. The anthropometric and bio chemical parameters (fasting blood sugar, lipid profile, serum insulin, high-sensitivity C-reactive protein, and retinol-binding protein 4) were estimated. The obese groups had significantly altered adiposity indices, insulin resistance parameters (fasting blood sugar (only in the metabolic syndrome group), serum insulin, HOMA-IR and QUICKI), index of inflammation (Creactive protein) and proatherogenic dyslipidemic profile (serum triglycerides, VLDL-cholesterol, and triglyce ride/ HDL-cho lesterol ratio). Retinol-binding protein 4 levels were elevated in the obese groups, but were not significant. Retinol-binding protein 4 levels were correlated with anthropometric parameters and atherogenic lipids, while C-reac tive protein was correlated with anthropometric and insulin resistance parameters in the entire group of subjects. Altho ugh these correlations were not observed in the obese groups, in the control group, retinol-binding protein 4 was Kratak sadr`aj: Retinol-vezuju}i protein 4 je adipocitokin koji ima zasebnu ulogu u razvoju insulinske rezistencije u gojaznosti i proaterogenog lipidskog profila, me|utim, ona kod ljudi nije razja{njena. Ova studija izvedena je kako bi se utvrdila uloga retinol-vezuju}eg proteina 4 kao poten cijalnog markera metaboli~kog sindroma kod gojaznih Indijaca (populacije sa visokim rizikom za {e}ernu bolest). Pedeset dvoje gojaznih ispitanika (indeks telesne mase > 23 kg/m 2 ) podeljeni su na one sa i bez metaboli~kog sindroma na osno vu kriterijuma IDF i upore|eni sa zdravim kontrolnim subjektima. Odre|eni su antropometrijski i biohemijski para metri ({e}er u krvi, lipidski profil, insulin u serumu, visokoosetljivi C-reaktivni protein i retinol-vezuju}i protein 4). U gojaznim grupama zna~ajno su bili izmenjeni adi pozni indeksi, parametri insulinske rezistencije ({e}e...

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Section: Discussionsupporting

confidence: 82%

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

Shivakumar¹,

Kumar²,

Aswathanarayan³

et al. 2012

Journal of Medical Biochemistry

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“…Several other studies also failed to find any association between the change of RBP4 concentration and insulin sensitivity after calorie restriction [21,24] and gastric bypass surgery [14,22]. Differences may be explained by variant insulin sensitivity indices and genetic variations.…”

Section: Discussionmentioning

confidence: 99%

“…Several studies demonstrated that circulating RBP4 concentrations decreased with body mass reduction after exercise training [8], calorie restriction [12,21], and gastric bypass surgery [11,14,22]. Also, changes in circulating RBP4 concentrations were associated with the change in BMI [11,22].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Exercise Training on Circulating Retinol-Binding Protein 4 and Cardiovascular Disease Risk Factors in Obese Men

et al. 2012

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Introduction: The purpose of this study was to investigate the effects of 12-week exercise training on circulating retinol-binding protein 4 (RBP4) concentration and cardiovascular disease (CVD) risk factors in obese men. Methods: 29 obese men (age 48 ± 2 years; BMI 29.6 ± 0.7 kg/m²) participated in a 12-week exercise program (50–70% maximal heart rates; 3 times/week) without calorie restriction. Anthropometric parameters, CVD risk factors (total cholesterol, high-density lipoprotein cholesterol (HDLC), low-density lipoprotein cholesterol, triglycerides (TG), and quantitative insulin sensitivity check index), and circulating RBP4 and adipokine (adiponectin, leptin, and interleukin-6 (IL-6)) concentrations were measured. Results: Exercise training significantly improved in absolute peak oxygen consumption (p < 0.05), and CVD risk factors (p < 0.05), with the exception of HDLC. There was a significant decrease in circulating RBP4, leptin, and IL-6 concentrations (p < 0.05). Stepwise regression analysis revealed that changes in RBP4 concentration were independently related to the changes in TG concentration (β = 0.46, p < 0.05). Conclusion: These results demonstrate that exercise training without calorie restriction improves several CVD risk factors and circulating RBP4 and adipokine concentrations. Moreover, the change in circulating RBP4 may be more associated with the improvements in TG concentration in obese men.

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“…Povezanost RBP4 sa lipidnim parametrima, pre i nakon smanjenja telesne mase, kao i značajan pad RBP4 nakon smanjenja telesne mase hirurškom intervencijom (dok insulinska senzitivnost i stepen inflamacije nisu imali uticaja), utvrdili su i Broch sa sar. [32]. Međutim, studija Huanga i sar.…”

Section: Retinol-vezujući Protein 4 -Metabolički Faktor Rizikaunclassified

Retinol-binding protein 4 and hyperinsulinemia: The link between obesity and cardiovascular disease

Klisić¹,

Jovanović²,

Kavarić³

et al. 2017

Tim Med Glas

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(1) DOM ZDRAVLJA PODGORICA, CRNA GORA, (2) KLINIČKI CENTAR CRNE GORE Sažetak:Kardiovaskularne bolesti (KVB) su vodeći uzrok smrtnosti u svetu, a gojaznost predstavlja jedan od glavnih faktora rizika za ove bolesti. Poremećena sekrecija adipokina [npr., visoke koncentracije retinol-vezujućeg proteina 4 (RBP4), rezistina, leptina, a niske koncentracije adiponektina], inflamacija niskog stepena, kao i povećana produkcija reaktivnih vrsta kiseonika, dovode do poremećaja niza signalnih puteva, insulinske rezistencije (IR), kao i KVB. RBP4 je skoro otkriven adipokin za koji se pretpostavlja da je usko povezan sa IR. Uprkos oprečnim rezultatima brojnih studija, pretpostavlja se da je ovaj protein značajan kardiometabolički faktor rizika, čije visoke koncentracije dovode do nastanka metaboličkog sindroma, tipa 2 dijabetesa i KVB. Bolje poznavanje patofizioloških mehanizama koji dovode do povećanja RBP4 i insulina u krvi mogu dovesti do pronalaska adekvatne terapeutske strategije u cilju smanjenja kardiovaskularnog rizika, pa samim tim i bolesti srca i krvnih sudova kod osoba sa viškom telesne mase. Ključne reči: kardiovaskularne bolesti, retinol-vezujući protein 4, insulinska rezistencija, gojaznost. Summary:Cardiovascular disease (CVD) is the leading cause of death in the world and obesity is one of the main risk factors. Irregular secretion of adipokines [e.g. high retinol binding protein 4 (RBP4), resistin, leptin, respectively, but low adiponectin], low-grade inflammation, as well as an increased production of reactive oxygen species, may lead to impaired insulin signalling, insulin resistance (IR) and CVD. RBP4 is a recently discovered adipokine which is supposed to be closely related to IR. Despite contradictory results obtained from a large number of studies, it is assumed to be a significant cardiometabolic risk factor, leading to metabolic syndrome, type 2 diabetes and CVD development. Better understanding of the patophysiological mechanisms of increased RBP4 and hyperinsulinemia in circulation may lead to a discovery of new target therapy in prevention of CVD, especially in those people who are overweight/obese.

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Association of Retinol-Binding Protein-4 (RBP4) with Lipid Parameters in Obese Women

Abstract: This study shows that, in obese women and after a substantial weight loss due to bariatric surgery, RBP4 was related to weight status and lipid parameters rather than to insulin sensitivity or inflammatory markers.

Cited by 44 publications

References 42 publications

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

Effects of Exercise Training on Circulating Retinol-Binding Protein 4 and Cardiovascular Disease Risk Factors in Obese Men

Retinol-binding protein 4 and hyperinsulinemia: The link between obesity and cardiovascular disease

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