Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

Shivakumar, Nirupama; Kumar, Meghanaa Jaya; Aswathanarayan, Manasa; Venkatesh, Maanasa; Sheshadri, Manasa; Deshmukh, Shreehari; Srinivasan, Pranav Honnavara; Dharmalingam, Mala; Marcus, Sara Rani

doi:10.2478/v10011-011-0032-4

Cited by 5 publications

(2 citation statements)

References 36 publications

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“…Some studies have shown that obesity and insulin resistance have also been associated with other risk factors such as elevated blood pressure (22,23). The Coronary Artery Risk Development in Young Adults (CARDIA) study of 4576 young adults reported a weight-independent association between fasting insulin concentration and hypertension (24).…”

Section: Discussionmentioning

confidence: 99%

The Association of Obesity and Liver Enzyme Activities in a Student Population at Increased Risk for Cardiovascular Disease / Veza Između Gojaznosti I Aktivnosti Jetrenih Enzima U Studentskoj Populaciji Sa Povećanim Rizikom Za Nastanak Kardiovaskularnih Bolesti

Čolak¹,

Pap²,

Majkić-Singh³

et al. 2013

Journal of Medical Biochemistry

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SummaryBackground: It has been reported that obesity is associated with metabolic syndrome, insulin resistance, cardiovascular risk but also with nonalcoholic fatty liver disease (NAFLD). The prevalence of obesity in children and adolescents is increasing rapidly all over the world. The aim of this study was to analyze the value of liver enzymes: AST, ALT and gGT in a group of obese students in order to establish their correlation to anthropometric parameters such as: BMI (body mass index), WC (waist circumference), HC (hip circumference), and WHR (waist-to-hip ratio) compared to non-obese students who comprised the control group (CG). Methods: In this study, 238 students from the University of Novi Sad of both sexes (126 men and 112 women) with a mean age of 22.32 ± 1.85 years were included. According to the body mass index (BMI) lower and higher than 25 kg/m 2 and waist circumference (WC) lower and higher than 94 cm (80 cm for females) the whole group of 238 students was divided into 2 subgroups: the obese group at increased risk for CVD (Group 1) and the group at lower risk for CVD (Group 2). AST, ALT and gGT activities were determined in fasting blood samples. Results: Statistical processing data revealed significantly higher values of AST, ALT and gGT in the group of students with BMI>25 kg/m 2 , WC>94 cm for males and WC>80 cm for females, HC>108 cm for males and HC>111 cm for females, and WHR>0.90 for males and WHR>0.80 for females (P<0.001). Significant association was established

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Section: Discussionmentioning

confidence: 99%

The Association of Obesity and Liver Enzyme Activities in a Student Population at Increased Risk for Cardiovascular Disease / Veza Između Gojaznosti I Aktivnosti Jetrenih Enzima U Studentskoj Populaciji Sa Povećanim Rizikom Za Nastanak Kardiovaskularnih Bolesti

Čolak¹,

Pap²,

Majkić-Singh³

et al. 2013

Journal of Medical Biochemistry

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“…RBP4 yang bersumber dari hati dan jaringan adiposa telah diketahui menjadi faktor resiko dari penyakit seperti resistensi insulin (Graham et al, 2006), metabolisme lemak seperti kolesterol, low density lipoprotein (LDL), Trigliserida, apolipoprotein B (apo B), Very low density lipoprotein (VLDL) (Christou, Tselepis, & Kiortsis, 2012), Diabetes mellitus tipe 2, penyakit jantung (Christou et al, 2012) dan Sindrom metabolik (von Eynatten et al, 2007). bahkan RBP4 dapat menjadi marker dari sindrom metabolik (Shivakumar et al, 2012).…”

Section: Faktor Resiko Dari Retinol Binding Protein 4 (Rbp4) Pada Obe...unclassified

Retinol Binding Protein 4 (Rbp 4) Pada Obesitas Sentral

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2022

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Obesity is currently a problem in the world. Lifestyles such as eating fast food, junk food, lack of activity and exercise which can cause obesity rates to increase every year. Obesity has a negative impact on health. Obesity may causing various diseases and may even causing death. Central obesity is a condition where the waist circumference is above 90 cm in men and above 80 cm in woman.Adipose tissue is also known as an endocrine organ that can release active mediators. One of the active mediators released is Retinol Binding Protein 4 (RBP4). RBP4 is a risk factor for diseases such as insulin resistance, affecting fat metabolisme such as increasing cholesterol, low swnsity lipoprotein (LDL), tryglicerides, apolipoprotein B (apo B), very low density lipoprotein (VLDL), diabetes mellitus type 2, heart disease and metabolic syndrome. RBP4 in subcutaneous adipose tissue is associated with several macrophages and inflammatory markers. RBP4 is known to increase TNFα which can stimulate lipolysis.

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Lipoproteins and other Risk Factors for Cardiovascular Disease in a Student Population

Pap¹,

Čolak²,

Majkić-Singh³

et al. 2013

Journal of Medical Biochemistry

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Summary Background: Cardiovascular disease (CVD) is a major cause of mortality and morbidity in many populations, especially in developed countries. The aim of the study was to analyze the lipid status in a student population at increased risk for CVD in comparison with students who are not at increased risk for CVD. Methods: This study included 238 students from the University of Novi Sad of both sexes (126 men and 112 women), with a mean age of 22.32±1.85 years. According to the body mass index (BMI) lower and higher than 25 kg/m2 and waist circumference (WC) of less and more than 94 cm (80 cm for females) the whole group of 238 students was divided into 2 subgroups: the group at increased risk for CVD (Group 1) and the group at lower risk for CVD (Group 2). Total cholesterol - TCH, triglycerides - TG, high density lipoprotein cholesterol - HDL-c, low density lipoprotein cholesterol - LDL-c, very low-density lipoprotein cholesterol - VLDL-c concentrations were determined and the index of atherosclerosis (IA), established risk factors RF-TCH/HDL-c ratio and non-HDL-c/HDL-c ratio were mathematically calculated. Results: The values of TCH, LDL-c, non-HDL-c, VLDL-c and TG were significantly higher in Group 1 compared to Group 2 (P<0.001). IA, non-HDL-c/HDL-c and RF-TCH/HDL-c ratio were also significantly higher (P<0.001), while HDL-c was significantly lower (p<0.01) in Group 1 compared to controls. These results were not influenced by gender in both groups of subjects. Conclusions: The data suggest that increased anthropometric parameters are followed by increased lipoprotein status in the group of students at increased risk for CVD and screening of the lipid status is necessary in students, especially in those who are at increased risk for CVD.

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Role of Retinol-Binding Protein 4 in Obese Asian Indians with Metabolic Syndrome

Cited by 5 publications

References 36 publications

The Association of Obesity and Liver Enzyme Activities in a Student Population at Increased Risk for Cardiovascular Disease / Veza Između Gojaznosti I Aktivnosti Jetrenih Enzima U Studentskoj Populaciji Sa Povećanim Rizikom Za Nastanak Kardiovaskularnih Bolesti

The Association of Obesity and Liver Enzyme Activities in a Student Population at Increased Risk for Cardiovascular Disease / Veza Između Gojaznosti I Aktivnosti Jetrenih Enzima U Studentskoj Populaciji Sa Povećanim Rizikom Za Nastanak Kardiovaskularnih Bolesti

Retinol Binding Protein 4 (Rbp 4) Pada Obesitas Sentral

Lipoproteins and other Risk Factors for Cardiovascular Disease in a Student Population

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