Association of retinol binding protein4 (RBP4) and ghrelin plasma levels with insulin resistance and disease severity in non‐diabetic patients with hidradenitis suppurativa

González‐López, Marcos A.; Ocejo‐Viñals, J. Gonzalo; Mata, Cristina; Vilanova, I.; Guiral, Sandra; Portilla, Virginia; Blanco, Ricardo; Hernández, José L.

doi:10.1111/exd.14132

Cited by 10 publications

(8 citation statements)

References 25 publications

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“…In the current study and other studies, there was no significant correlation between ghrelin levels and anthropometric or metabolic variables. These studies included non-diabetic adolescents and healthy adults ( 28 , 43 ). In addition, earlier studies reported that exogenous ghrelin administration induced insulin resistance in rats and humans ( 44 , 45 , 46 ).…”

Section: Discussionmentioning

confidence: 99%

Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids

Xiong

et al. 2022

Endocrine Connections

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Objective: Ghrelin regulates body weight, food intake and blood glucose. It also regulates insulin secretion from pancreatic islet cells. LEAP2 is a newly discovered endogenous ligand of growth hormone secretagogue’s receptor (GHSR). It not only antagonizes the stimulation of GHSR by ghrelin but also inhibits constitutive activation of GHSR as an inverse agonist. Type 2 diabetes (T2D) patients have endocrine disorders with metabolic imbalance. Plasma levels of ghrelin and LEAP2 may be changed in obese and T2D patients. However, there is no report yet on circulating LEAP2 levels or ghrelin/LEAP2 ratio in T2D patients. In this study, fasting serum ghrelin and LEAP2 levels in healthy adults and T2D patients were assessed to clarify the association of two hormones with different clinical anthropometric and metabolic parameters. Design: A total of 16 females and 40 males, ages 23-68 years old normal (n = 27) and T2D patients (n = 29) were enrolled as a cross-sectional cohort. Results: Serum levels of ghrelin were lower but serum levels of LEAP2 were higher in T2D patients. Ghrelin levels were positively correlated with fasting serum insulin levels and HOMA-IR in healthy adults. LEAP2 levels were positively correlated with age and HbA1c in all tested samples. Ghrelin/LEAP2 ratio was negatively correlated with age, fasting blood glucose and HbA1c. Conclusions: This study demonstrated a decrease in serum ghrelin levels and an increase in serum LEAP2 levels in T2D patients. LEAP2 levels were positively correlated with HbA1c, suggesting that LEAP2 was associated with T2D development. The ghrelin/LEAP2 ratio was closely associated with glycemic control in T2D patients showing negative correlation with glucose and HbA1c.

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Section: Discussionmentioning

confidence: 99%

Serum levels of ghrelin and LEAP2 in patients with type 2 diabetes mellitus: correlation with circulating glucose and lipids

Xiong

et al. 2022

Endocrine Connections

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“…RBP4 is also a transport protein for free vitamin A [ 56 ]. In a cross-sectional study of 137 patients (77 HS patients and 60 controls) without diabetes mellitus, higher RBP4 and lower ghrelin levels were found in HS [ 57 ]. RBP4 levels correlated positively with disease severity and insulin resistance in HS patients independent of BMI [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

The Role of Hormones in Hidradenitis Suppurativa: A Systematic Review

Rached

Gambichler

Dietrich

et al. 2022

IJMS

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Hidradenitis suppurativa (HS) is a chronic inflammatory disease manifesting in inverse body regions. In a systematic review, the role of hormones in HS will be presented to better understand the pathomechanisms of HS. The review is based on the PRISMA criteria. Systematic research was carried out using keywords. Subsequently, the data were analyzed based on the clinical response and other relevant information. The main focus of our systematic review was on HS manifestation, exacerbation, sex hormones, antiandrogen therapy, thyroid function, polycystic ovary syndrome, insulin resistance, and adipokines. In HS, there appears to be a dysregulated adipokine release that is shifted towards pro-inflammatory adipokines. Insulin resistance is significantly more common in HS than in healthy patients regardless of BMI, age, and gender. Insulin resistance in HS patients leads to further cardiovascular disease. The mechanism of insulin resistance and role of adipokines should be investigated in future studies to better provide the pathomechanisms of HS. The role of androgens seems to be important in a certain subgroup of female patients. Anti-androgenic therapy can be useful and helpful in some patients. However, further studies are needed to better understand the hormonal relationship in HS.

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“…[49,50] This concept is alos in line with newly recognized endocrine abnormalities associated with hidradentitis suppurative/ acne inversa. Gonzaléz-López et al [51] who found that low plasma levels of ghrelin, a predominant stomach-derived hormone, as well as high plasma levels of retinol-binding protein-4, may serve as novel biomarkers for insulin resistance in hidradenitis suppurativa indicating an increased risk. This is further elaborated exemplarily by Briganti et al [52] who examine acne as the phenotypic result of altered dermato-endocrine responses of human skin, and by Zouboulis, [53] who argues in a provocative and highly stimulating essay that the coordinated activities of endocrinological, metabolic and immunological/inflammatory factors drive acne pathogenesis, with peroxisome proliferator-activated receptors functioning as a putative regulatory hub, in line with similar arguments that have been developed for the role of these receptors in human hair follicle physiology and pathology.…”

Section: E D I T O R I a L Towards A Renaissance Of Dermatoendocrinolmentioning

confidence: 99%

“…This concept is alos in line with newly recognized endocrine abnormalities associated with hidradentitis suppurative/acne inversa. Gonzaléz‐López et al [51] who found that low plasma levels of ghrelin, a predominant stomach‐derived hormone, as well as high plasma levels of retinol‐binding protein‐4, may serve as novel biomarkers for insulin resistance in hidradenitis suppurativa indicating an increased risk.…”

mentioning

confidence: 99%