Association of retinopathy and intima media thickness of common carotid artery in type 2 diabetic patients

AimsAtherosclerosis and ischemic heart disease are more common in diabetic patients. Atherosclerosis process can disturb the normal functioning of the vascular endothelium and increase vessel wall thickness. The aim of this study was the comparison of Carotid intima-media thickness (CIMT) with Exercise tolerance test as an alternative way to evaluate cardiac ischemia in diabetic patients.MethodsIn a cross-sectional study, 30 diabetic patients with positive exercise test and 30 diabetic patients with negative exercise test were enrolled. CIMT of the carotid artery in both groups of patients was measured.ResultCIMT in the patients with positive and negative exercise test were 1.04 ± 0.21 mm and 0.61 ± 0.11 mm, respectively (P < 0.001). CIMT in positive exercise test group was positively associated with age and negatively associated with gender, FBS, HDL and LDL cholesterol and in negative exercise group was negatively associated with gender, age, FBS, HDL and LDL cholesterol.ConclusionConsidering observed significant positive association between CIMT with result of exercise tolerance test (ETT) in type 2 diabetic patients, it may possible to use CIMT as an inexpensive and non-invasive method for evaluation of ischemic heart disease in diabetic patients.

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Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients

Momeni

Taheri

Mansuri

et al. 2018

IJC Heart & Vasculature

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Vascular responsiveness in type 2 diabetes mellitus (T2DM)

Blum

Socea

Sirchan

2016

QJM

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The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes

Ichinohasama

Kunikata

Ito

et al. 2019

Journal of Ophthalmology

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Purpose. To compare clinical findings, including ocular blood flow and intima-media thickness (IMT) of the carotid artery, in mild nonproliferative diabetic retinopathy (NPDR) and no diabetic retinopathy (NDR) patients, and to determine risk factors contributing to mild NPDR. Methods. In 129 subjects (129 eyes) with type-2 diabetes patients and mild NPDR or NDR, standard statistical techniques were used to determine associations between clinical findings, including diabetes duration, blood levels of creatinine and hemoglobin A1c (HbA1c), central macular thickness (CMT; measured with optical coherence tomography), mean blur rate (MBR; measured with laser speckle flowgraphy), and ultrasound-measured carotid IMT. Results. Diabetes duration, IMT, and CMT were significantly higher in the mild NPDR patients than the NDR patients (P=0.004, P=0.004, and P=0.003, respectively), while conversely, MBR in the overall optic nerve head (MBR-A) was lower in the mild NPDR patients. Furthermore, a logistic regression analysis showed that diabetes duration (OR, 1.11; P=0.006), diastolic blood pressure (OR, 0.93; P=0.025), heart rate (OR, 1.07; P=0.004), IMT (OR, 8.65; P=0.005), and CMT (OR, 1.03; P=0.007) were independent contributing factors to mild NPDR. Spearman’s rank correlation test also showed that IMT was negatively correlated with MBR-A (P=0.011). Conclusions. Increased IMT showed a close association with ocular ischemia in patients with type-2 diabetes and contributed to the presence of mild NPDR. These findings suggest that IMT may be an early biomarker of mild NPDR.

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Association of retinopathy and intima media thickness of common carotid artery in type 2 diabetic patients

Cited by 3 publications

References 26 publications

Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients

Association of carotid intima-media thickness with exercise tolerance test in type 2 diabetic patients

Vascular responsiveness in type 2 diabetes mellitus (T2DM)

The Relationship between Carotid Intima-Media Thickness and Ocular Circulation in Type-2 Diabetes

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