Association of risk factors of GDM with outcome of GCT in obstetrical population

Sohail, Rubina; Bashir, Tahir; Javaid, Khalida; Zaman, Farrukh

doi:10.21649/akemu.v10i1.1141

Cited by 2 publications

(1 citation statement)

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“…Sohail R et al also found similar results to what we noted. 20 Jamshed et al showed GDM in 6.7% women and had significant linkage with increased parity, obesity and family history of DM which is similar to our study. 21 A study conducted in Karachi, Pakistan showed 15.8% women with GDM while study done in Rawalpindi obtained a prevalence rate of 8% which is very close to what we observed.…”

Section: Discussionsupporting

confidence: 92%

Importance of Blood Glucose Monitoring in Pregnant Females

Ghafoor¹,

Qayyum²,

Ghazi³

et al. 2022

PJMHS

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Objective: To determine the frequency of gestational diabetes mellitus (GDM) among pregnant females. Study Design: Cross-sectional study. Place and Duration: Department of Gynecology and Obstetrics, and department of Pathology, Dow University of health sciences, From February 2021 to January 2022. Methodology: Five hundred pregnant ladies with gestational age between 24-28 weeks with any parity were included. These women were challenged with 75 grams of oral glucose solution and blood glucose levels were estimated at one-hour post-prandial. The cut-off limit was set to 140 mg/dl and women with more than this value were subjected to a 2 hr 75 grams oral glucose tolerance test to confirm the diagnosis of GDM. Results: Out of a total of 500 pregnant women, the mean age, gestational age and BMI were 26.4±4.3 years, 27.0±10.2 weeks and 27.6±4.3 kg/m2. There were 59 (11.8%) women who were found to have a positive glucose challenge test (GCT) while the remaining 441 (88.2%) had plasma glucose below 140 mg/dl. Furthermore, 59 OGTT results showed that 43 (8.6%) women had GDM. Women with GDM had significantly higher age (p<0.0001), higher BMI (p=0.0064) and multigravidity (0.0191) Practical Implications: Oral glucose challenge test can be administered in all pregnant women particularly in high risk individuals. Conclusion: The frequency of GDM was high. Pregnant ladies should be screened for GDM in time to prevent further complications during and after pregnancy. Keywords: Blood glucose, gestational diabetes mellitus, post-prandial.

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Section: Discussionsupporting

confidence: 92%

Importance of Blood Glucose Monitoring in Pregnant Females

Ghafoor¹,

Qayyum²,

Ghazi³

et al. 2022

PJMHS

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Development and validation of a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for the screening of high-risk pregnant women for gestational diabetes mellitus in Pakistan

Naz,

Jamal,

Jaffar

et al. 2024

bmjph

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IntroductionThe prevalence of gestational diabetes mellitus (GDM) is on the rise in low-income and middle-income countries, such as Pakistan. Therefore, the development of a risk score that is simple, affordable and easy to administer is needed. Our study aimed to develop a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for GDM screening in Pakistani pregnant women based on risk factors reported in the literature.MethodsUsing a cross-sectional study design, we enrolled 500 pregnant women who attended antenatal clinics at one tertiary and two secondary care hospitals in Karachi between the 28th and 32nd weeks of gestation. We randomly divided data into derivation (n=404; 80%) and validation datasets (n=96; 20%). We conducted interviews to collect information on sociodemographic factors and family history of diabetes, measured mid-upper arm circumference (MUAC) and reviewed the medical records of women for obstetric history and oral glucose tolerance test (OGTT) results. We performed a multivariable logistic regression analysis to obtain coefficients of selected predictors for GDM in the derivation dataset. Calibration was estimated using Pearson’s χ2 goodness of fit test while discrimination was checked using the area under the curve (AUC) in the validation dataset.ResultsOverall, the GDM prevalence was 26% (n=130). INSPIRE was based on six predictors: maternal age, MUAC, family history of diabetes, a history of GDM, previous bad obstetrical outcome and a history of macrosomia. INSPIRE achieved a good calibration (Pearson’s χ2=29.55, p=0.08) and acceptable discrimination with an AUC of 0.721 (95% CI 0.61 to 0.83) with a sensitivity of 74.1% and specificity of 59.4% in the validation dataset.ConclusionWe developed and validated an INSPIRE that efficiently differentiates Pakistani pregnant women at high risk of GDM from those at low risk, thus reducing the unnecessary burden of the OGTT test.

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Association of risk factors of GDM with outcome of GCT in obstetrical population

Cited by 2 publications

References 0 publications

Importance of Blood Glucose Monitoring in Pregnant Females

Importance of Blood Glucose Monitoring in Pregnant Females

Development and validation of a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for the screening of high-risk pregnant women for gestational diabetes mellitus in Pakistan

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