Association of rs662799 in APOA5 with CAD in Chinese Han population

Chen, Hua; Ding, Shifang; Zhou, Mei; Wu, Xin-ai; Liu, Xi; Wu, Yun; Liu, Dechao

doi:10.1186/s12872-017-0735-7

Cited by 17 publications

(13 citation statements)

References 20 publications

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“…Currently, multiple mutation sites have been detected, among which −1131 T>C (rs662799) and 56 C>G (rs3135506) were believed to be related to hypertriglyceridemia. −1131 T>C may affect gene transcription and lower serum ApoA5 level . The frequency of the APOA5 −1131C allele is higher in East Asians (>25%) than in Westerners (9%‐16%) .…”

Section: Resultsmentioning

confidence: 99%

Pharmacogenetics of statins treatment: Efficacy and safety

Guan

et al. 2019

J Clin Pharm Ther

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What is known and objective: Statins are widely used worldwide in the prevention and treatment of coronary atherosclerotic heart disease and ischaemic stroke.However, in clinical application, statins have shown great individual differences in terms of the efficacy and safety, some of which are related to genetic factors. The purpose of this article was to summarize the recent advances about the correlation between gene polymorphisms and the efficacy/safety of statins. Methods:We searched the databases including PharmGKB and PubMed (published before June 2019) using the keywords such as 'statin', 'gene polymorphism' and 'SNP' and obtained more than 100 articles. In this review, we described the clinical studies of genetic variants associated with both the efficacy and adverse reactions of statins.We also clarified the importance of taking pharmacogenetic variation into account to improve the clinical application of statins. Results and discussion:The available data were collected and analysed to present the polymorphisms of candidate genes encoding the most promising proteins including SLCO1B1 (encoding uptake transporters); ABCB1, ABCC2, ABCG2 (encoding effluent transporter); APOE, APOA5 (encoding apolipoprotein); genes encoding cytochrome P450 enzyme system; KIF6, HMGCR, LDLR, LPA, PCSK9, COQ2, CETP, etc These genes were proved to be related to the pharmacodynamics and pharmacokinetics of statins, thus affecting the efficacy and safety. What is new and conclusion:In this paper, the correlation between gene polymorphisms and the efficacy/safety of statins was summarized. The authors reached a consensus that the variants of the genes encoding uptake and effluent transporters have the most effect on the efficacy/safety of statins. It pointed out that it is desirable to do genetic testing of these transporter genes to reduce the incidence of myopathy or to achieve better outcomes before patients use statins, especially in the regions with high frequency of risk allele. K E Y W O R D S cytochrome P450, gene polymorphism, pharmacogenetics, statins, transporter | 859 GUAN et Al.

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Section: Resultsmentioning

confidence: 99%

Pharmacogenetics of statins treatment: Efficacy and safety

Guan

et al. 2019

J Clin Pharm Ther

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“…26.7 and 28.9% in European, African, Chinese and Japanese respectively. Chen H et al [49] found a signi cant association of the SNP rs662799 in APOA5 genes with CAD. Valente-Frossard TNS [50] showed in their study that genotypes of the APOA5 rs662799 were not associated with lipid levels.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

Abudureyimu

Abulaiti

Xing

et al. 2021

Preprint

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Background: In this current work we aimed to find the effect of four different single Nucleotide Polymorphisms(SNPs) rs1122608(SMARCA4)，rs2230806(ABCA1), rs12563308（ANGPTL3）,and rs662799（APOA5 ) on coronary heart disease(CHD) in a Han Chinese population in Xinjiang region of China. Methods: This study involved 914 subjects with 493 CHD patients and 421 healthy controls. The genotype distribution of analyzed and their relations with CHD risk factors were assessed.Results: No statistical differences were found in genotype and allele distributions of above SNPs between CHD and healthy controls (P>0.05). Serum level of high-density lipoprotein cholesterol (HDL-C) was higher in in TT genotype of rs1122608 when compared with GT and GG genotypes (P< 0.01) in CHD patients ; serum triglyceride(TG) level was higher in rs662799 GG genotype than GA and AA genotypes(P <0.00); AA of rs662799 was associated with higher HDL-C level compared with other two genotypes (P < 0.01) ; rs12563308 and rs223086 were not associated with any serum lipid traits (P > 0.05 for all). Logistic regression analysis showed that the SNPs examined were not related to CHD (p > 0.05). Also no association was found between four SNPs with the angiographic severity of CHD patients (p > 0.05). Conclusions: APOA5 rs662799 GG allele is associated with elevated triglyceride and might act as a risk factor for CHD; SMARCA4 rs1122608 TT allele and APOA5 rs662799 AA allele are associated with elevated high-density lipoprotein cholesterol levels, and might play a protective role in the development of CHD.

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“…CAD is a complex disease and its etiology and pathogenesis are likely polyfactorial due to the inheritance of several susceptibility genes, as well as multiple environmental factors [20,21].Recently, there has been an increase in the in-depth research on the role of SNPs in the pathogenesis of CAD [22]. Ultimately, studying genetic backgrounds might provide new insights to explore diagnostic and therapeutic approaches for CAD [23].…”

Section: Discussionmentioning

confidence: 99%

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

Zhang

Zhao

et al. 2020

Preprint

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Background: Coronary artery disease (CAD) is the most common type of heart disease and causes high morbidity worldwide. The β3-adrenergic receptor gene (ADRB3) is potentially linked to obesity, insulin resistance, diabetes, and hypertension based on its role in energy homeostasis and lipolysis in human adipose tissue. However, the relationship between ADRB3 gene polymorphisms and CAD remains unclear. we sought to assess this association in the Han and Uygur populations of China. Methods: We used the following two case-control studies: a Han population (308 CAD patients and 294 control subjects) and an Uygur population (259 CAD patients and 161 control subjects). All 1022 participants were genotyped for the two single nucleotide polymorphisms (SNPs) (rs1892818, rs9693898) of ADRB3 using real-time polymerase chain reaction (TaqMan). Results: We found that the rs1892818 CT genotype (8.5% compared with 3.9%, P = 0.019) and T allele (4.3% compared with 1.9%, P = 0.021) were more frequent in control subjects than in CAD patients of the Han, but not Uygur population. No significant differences in rs9693898 of ADRB3 were found between CAD patients and control subjects for both populations. After adjusting for other confounders, logistic regression analysis suggested that the difference remained significant between the two groups in the Han population (CT compared with CC, P = 0.036, OR = 0.410, 95% CI: 0.178–0.944). Conclusion: Our results suggest that ADRB3 rs1892818 is associated with CAD in a Han population and that the CT genotype of ADRB3 rs1892818 might be a protective factor for CAD in Han individuals.

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Association of rs662799 in APOA5 with CAD in Chinese Han population

Cited by 17 publications

References 20 publications

Pharmacogenetics of statins treatment: Efficacy and safety

Pharmacogenetics of statins treatment: Efficacy and safety

The Effect of Four Different Single Nucleotide Polymorphisms on Coronary Heart Disease in a Han Chinese Population in Xinjiang Region

The rs1892818 polymorphism of ADRB3 is associated with coronary artery disease in a Han population

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