Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study

Caixeta, Douglas Carvalho; Pennisi, Pedro Rogério Camargos; Moura, Douglas Vieira; Nunes, Marjorie Adriane Costa; Espindola, Foued Salmen; Blumenberg, Cauane; Paranhos, Luiz Renato; Sabino-Silva, Robinson

doi:10.1590/1516-3180.2021.0816.r2.19052022

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…37 A2m, an essential gene of the innate immune system, functions by suppressing inflammatory cytokines to disrupt the inflammatory process. 38 In mice, A2m exerts its anti-inflammatory effects by regulating cytokines and immunomodulatory lipid mediators. 39,40 Notably, A2m expression levels were observed to rise in both hibernating bears and hibernating ground squirrels.…”

Section: Qrt-pcr Experimental Verification Resultsmentioning

confidence: 99%

“…For instance, proteomic analysis of hibernating American black bears showed a fourfold increase in Hp expression during hibernation 37 . A2m , an essential gene of the innate immune system, functions by suppressing inflammatory cytokines to disrupt the inflammatory process 38 . In mice, A2m exerts its anti‐inflammatory effects by regulating cytokines and immunomodulatory lipid mediators 39,40 .…”

Section: Discussionmentioning

confidence: 99%

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Adapting to stress: The effects of hibernation and hibernacula temperature on the hepatic transcriptome of Rhinolophus pusillus

Wang,

Chen

et al. 2024

The FASEB Journal

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Hibernation, a survival strategy in mammals for extreme climates, induces physiological phenomena such as ischemia–reperfusion and metabolic shifts that hold great potential for advancements in modern medicine. Despite this, the molecular mechanisms underpinning hibernation remain largely unclear. This study used RNA‐seq and Iso‐seq techniques to investigate the changes in liver transcriptome expression of Rhinolophus pusillus during hibernation and active periods, as well as under different microhabitat temperatures. We identified 11 457 differentially expressed genes during hibernation and active periods, of which 395 showed significant differential expression. Genes associated with fatty acid catabolism were significantly upregulated during hibernation, whereas genes related to carbohydrate metabolism and glycogen synthesis were downregulated. Conversely, immune‐related genes displayed differential expression patterns: genes tied to innate immunity were significantly upregulated, while those linked to adaptive immunity and inflammatory response were downregulated. The analysis of transcriptomic data obtained from different microhabitat temperatures revealed that R. pusillus exhibited an upregulation of genes associated with lipid metabolism in lower microhabitat temperature. This upregulation facilitated an enhanced utilization rate of triglyceride, ultimately resulting in increased energy provision for the organism. Additionally, R. pusillus upregulated gluconeogenesis‐related genes regardless of the microhabitat temperature, demonstrating the importance of maintaining blood glucose levels during hibernation. Our transcriptomic data reveal that these changes in liver gene expression optimize energy allocation during hibernation, suggesting that liver tissue adaptively responds to the inherent stress of its function during hibernation. This study sheds light on the role of differential gene expression in promoting more efficient energy allocation during hibernation. It contributes to our understanding of how liver tissue adapts to the stressors associated with this state.

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Section: Qrt-pcr Experimental Verification Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adapting to stress: The effects of hibernation and hibernacula temperature on the hepatic transcriptome of Rhinolophus pusillus

Wang,

Chen

et al. 2024

The FASEB Journal

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Fully covered versus partially covered self-expandable metal stents for palliation of distal malignant biliary obstruction: a systematic review and meta-analysis

Vanella,

Coluccio,

Cucchetti

et al. 2024

Gastrointestinal Endoscopy

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Correlational analysis between salivary and blood glucose levels in individuals with and without diabetes mellitus: a cross-sectional study

Shettigar,

Sivaraman,

Rao

et al. 2024

AOS

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Objective: To estimate the association of patient-related demographic, socioeconomic status, physical activity, stress, and dietary factors influencing the relationship between salivary and blood glucose levels in individuals with and without diabetes mellitus (DM). Method: This cross-sectional study was conducted on 166 participants with and without DM. Saliva and blood were collected to estimate the glucose levels. Age, gender, occupation, socioeconomic and education level, BMI, hip to waist circumference, stress, dietary pattern, lifestyle, physical activity, family history of diabetes, and type of diabetes were recorded. The association of saliva to predict blood glucose levels was analysed using Spearman Rank Correlation and how these patient-related factors influence the correlation was estimated for future machine learning models. The difference in medians for various groups was calculated using the Mann-Whitney U Test or Kruskal Wallis Test. Results: Blood glucose level is not significantly correlated to salivary glucose level. However, a statistically significant difference in the median blood glucose levels for diabetic participants (median = 137) compared to healthy controls (p-value < .05) was noted. The correlation between blood and salivary glucose was more positive for higher levels of glucose (Spearman 0.4). Age, alcohol consumption, monthly wages, intake of vegetables, and socioeconomic status affect blood glucose levels. Conclusion: A correlation between saliva and blood glucose levels in healthy individuals was weak. Saliva should only be used as a monitoring tool rather than a diagnostic tool and is more reliable for patients with poorly controlled diabetes mellitus.

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Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study

Abstract: Association of salivary alpha-2-macroglobulin with glycemia and glycated hemoglobin in type 2 diabetes mellitus: a systematic review and meta-analysis study | ORIGINAL ARTICLE

Cited by 3 publications

References 37 publications

Adapting to stress: The effects of hibernation and hibernacula temperature on the hepatic transcriptome of Rhinolophus pusillus

Adapting to stress: The effects of hibernation and hibernacula temperature on the hepatic transcriptome of Rhinolophus pusillus

Fully covered versus partially covered self-expandable metal stents for palliation of distal malignant biliary obstruction: a systematic review and meta-analysis

Correlational analysis between salivary and blood glucose levels in individuals with and without diabetes mellitus: a cross-sectional study

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