Association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal females

Tariq, Saba; Tariq, Sundus; Shahzad, Muhammad

doi:10.12669/pjms.37.2.3907

Cited by 8 publications

(7 citation statements)

References 24 publications

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“…In addition, serum RARRES2 levels were found to be independent negative predictor of BMD at the right and left femoral neck. Similar results were observed in other studies in which they found significantly increased levels of RARRES2 in osteoporotic patients ( 5 , 20 ). In another study conducted on Chinese obese postmenopausal women, similar findings were observed.…”

Section: Discussionsupporting

confidence: 92%

Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females

Tariq

Tariq²,

Khaliq³

et al. 2022

Front. Endocrinol.

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BackgroundAdipokines are engaged in bone physiology and regulate bone mineral density (BMD) by playing protective or cynical role in bone metabolism. The study is designed to measure and compare BMD, adipokines (retinoic acid receptor responder protein-2 RARRES2, visfatin and Intelectin-1) and their genetic variants in postmenopausal osteoporotic, osteopenic and non-osteoporotic females.MethodsThis comparative study included postmenopausal non-osteoporotic (n=72), osteopenic (n=72) and osteoporotic (n=100) females with two years of amenorrhea and age between 50 to 70 years. Gold standard DXA was used to measure BMD. Hardy-Weinberg equilibrium was established. Kruskal-Wallis test for comparisons, logistic and multivariate regression analysis were used to rule out the predictors of BMD.ResultsOn comparing the three groups, significant differences were observed in serum RARRES2 (p <0.001) and serum visfatin (p=0.050). The significant positive predictor of BMD at lumbar spine and total hip was serum visfatin. BMD at right and left femoral neck was predicted negatively by serum chemerin while BMD at left femoral neck was also predicted positively by serum calcium levels. There was significant difference in BMD at right femoral neck (p = 0.033) between rs7806429 genotypes. The odds of having low BMD increases with increasing serum levels of chemerin and decreasing serum levels of visfatin and calciumConclusionThe adipokines RARRES2 and visfatin are associated with BMD. RARRES2 is an independent negative and visfatin is positive predictor of BMD in postmenopausal females. BMD at right femoral neck was significantly low in RARRES2 rs7806429 TC heterozygotes.

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Section: Discussionsupporting

confidence: 92%

Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females

Tariq

Tariq²,

Khaliq³

et al. 2022

Front. Endocrinol.

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“…However, an in vitro study used Alizarin Red S staining and serum T-ALP measurements in cultured bone marrow mesenchymal stem cells to evaluate osteogenesis and suggested that increased BMD and T-ALP activity can prevent OVX-induced osteoporosis in rats [ 33 ]. Furthermore, a cross-sectional Pakistani study showed no correlation between BMD and serum T-ALP levels by linear regression analysis ( p = 0.869) [ 13 ]. Thus, further studies based on larger statistical samples are required to substantiate the significance of the serum T-ALP and BMD correlations.…”

Section: Discussionmentioning

confidence: 99%

“…They can be measured in urine or serum and can indicate the bone turnover rate [ 5 ]. As serum T-ALP levels have been considered a potential biomarker of bone formation and are widely used in routine screening tests [ 13 ], several studies have demonstrated that serum T-ALP is a useful indicator for assessing and tracking the presence or absence of osteoporosis [ 14 ]. However, there is no consistent conclusion about the association between serum T-ALP and BDM.…”

Section: Introductionmentioning

confidence: 99%

The correlation between serum total alkaline phosphatase and bone mineral density in young adults

Shu

Tan

et al. 2022

BMC Musculoskelet Disord

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Background Elevated total alkaline phosphatase (T-ALP) levels are usually indicative of enhanced osteoblastic activity and bone conversion status and are thus considered as a key factor needed for fresh bone mineralization and synthesis. To date, there is no consistent conclusion on the association between the serum T-ALP levels and bone mineral density (BMD). Therefore, the present study focused on exploring the association of serum T-ALP with lumbar BMD among young adults. Methods The present cross-sectional study included 6,331 subjects included in the National Health and Nutrition Examination Survey (NHANES) during 2011–2016. The participants aged 20–40 years included 3,349 males and 2,982 females. Serum T-ALP was our main variable, lumbar BMD was our outcome variable, and additional variables were the possible impact modifiers. The relations were analysed by the trend study, weighted multiple linear regression models, smooth curve fitting, and stratified analyses. Results In a completely corrected multiple regression model, a negative association between serum T-ALP and lumbar BMD was discovered (β = -0.0007, 95% CI: –0.0009– –0.0005, P < 0.000001). After converting the continuous variable serum T-ALP into the categorical one, the significant negative association was still observed (P < 0.001), and in the subgroup and smooth curve fitting analyses, this negative correlation remained significant, too. Conclusions Our study results indicated that serum T-ALP was negatively associated with lumbar BMD among young adults. Serum T-ALP measurement in the near future might become an effective biomarker to diagnose and treat osteoporosis on time.

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“…There have been several studies on the relationship between body mass index and bone mineral density in women, but only a few on men so far (6). The preservation of the skeletal system is determined by calcium, which is one of the essential minerals involved in bone homeostasis and is linked to increased bone minerals (7)(8). Reduced (BMI) is a good risk factor for future fracture (9).…”

Section: Introductionmentioning

confidence: 99%

Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

ABED¹,

Rasheed²,

G.Hussein³

2022

JFacMedBagdad

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Background: Type 2 diabetes negatively affects the biochemical parameters of bone turnover more than obesity and is associated with an increased risk of osteoporosis and fragility fractures. Obesity and type 2 diabetes (T2DM) are linked to increased fracturing risk; however, the effect of obesity on diabetes-related bone deficit is unknown. Objective: The goal of this research is to compare the indications, bone density, and bone turnover in T2DM men and a control group, and to investigate the effect of body mass index on bone turnover levels. Subjects, Material and Method: This case-control study was conducted on 120 men whose ages were from 40 - 69 years. They were grouped into two categories: T2DM (n=80) and healthy control (n=40). Serum samples from both groups were analyzed for blood glucose, Calcium and Albumin, by using (Cobas c111), PTH by (Cobas e 411), P1NP and CTX-1 levels in the serum using ELISA kits. Participants underwent (DEXA) measuring Bone Mass Density (BMD) at the lumbar spine. Results: The control (obese and non-obese) participants had statistically significant higher levels of CTX-1 and P1NP than the patients (obese and non-obese) (P-value = 0.000). There was no significant differences in Spine BMD, T-score (p-value = 0.27 and 0.37 respectively). Conclusion: Men with T2DM had a low bone turnover level and deteriorated bone quality compared to controls. The obese healthy controls can maintain healthy bone metabolism if T2DM is prevented.

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Association of serum chemerin with calcium, alkaline phosphatase and bone mineral density in postmenopausal females

Cited by 8 publications

References 24 publications

Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females

Association of serum levels of Visfatin, Intelectin-1, RARRES2 and their genetic variants with bone mineral density in postmenopausal females

The correlation between serum total alkaline phosphatase and bone mineral density in young adults

Assessment of Total Procollagen Type 1 Intact N-terminal Propeptide, C-telopeptide of type 1 collagen, Bone Mineral Density and its Relationship to Body Mass Index in Men with Type 2 Diabetes

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