Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men—the Third National Health and Nutrition Examination Survey

Gillum, R. F.

doi:10.1038/sj.ijo.0801561

Cited by 181 publications

(155 citation statements)

References 25 publications

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“…In the present study, CRP was associated mainly with TFM and BF% despite a minimal difference for the other indicators of adiposity. Other authors have reported an association of CRP with BMI and the waist-hip ratio (33). CRP was also associated with insulin and HOMA-IR values, similar to that described in the literature (34) indicating that the analysis of this cardiovascular risk marker can help to detect individuals with a higher tendency for insulin resistance independently of adiposity.…”

Section: Association Between Adiposity Indicators Metabolic Parametesupporting

confidence: 64%

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

Coutinho

Leite

Lopes

et al. 2015

Arch. Endocrinol. Metab.

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Objective: The aim of this study was to investigate the association between total and abdominal adiposity with metabolic parameters and inflammatory markers, in female adolescents. Subjects and methods: The sample consisted of 53 adolescents aged 13 to 17 years from a public school in Curitiba, Brazil. The adiposity indicators studied were body mass index (BMI), waist circumference (WC), trunk fat mass (TKFM), total fat mass (TFM) and body fat percentage (BF%) measured by dual-energy X-ray absorptiometry. The metabolic and inflammatory parameters studied were systolic blood pressure (SBP), diastolic blood pressure (DBP), glucose, insulin, homeostasis model assessment index for insulin resistance (HOMA-IR), lipids, C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), leptin, adiponectin and resistin. Results: Eighty percent of WC variation, 87% of TKFM and TFM, and 73% of BF% were predicted by BMI variation. There was a significant positive correlation between all indicators of adiposity with SBP, DBP, insulin, HOMA-IR, CRP and leptin. Triglycerides were positively correlated with BMI and WC, and adiponectin correlated negatively with BMI. TNF-α, IL-6, glucose, total cholesterol, and high-and low-density lipoprotein cholesterol did not correlate to the studied variables. Conclusion: BMI showed a significant association with most of the parameters studied, and WC was slightly better than BMI to predict insulin resistance in this specific population. Arch Endocrinol Metab. 2015;59(4):325-34

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Section: Association Between Adiposity Indicators Metabolic Parametesupporting

confidence: 64%

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

Coutinho

Leite

Lopes

et al. 2015

Arch. Endocrinol. Metab.

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“…28 In contrast, in obese subjects, SF tends to be higher than that in normal weight individuals and inversely related to transferrin saturation. 20,21,53 This suggests SF, an acute phase protein that can be elevated in inflammatory conditions even in the presence of iron deficiency, may be increased by adiposemediated inflammation. Our data support this.…”

Section: Discussionmentioning

confidence: 99%

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

et al. 2008

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Background: Overweight is increasing in transition countries, while iron deficiency remains common. In industrialized countries, greater adiposity increases risk of iron deficiency. Higher hepcidin levels in obesity may reduce dietary iron absorption. Therefore, we investigated the association between body mass index (BMI) and iron absorption, iron status and the response to iron fortification in populations from three transition countries (Thailand, Morocco and India). Methods: In Thai women (n ¼ 92), we examined the relationship between BMI and iron absorption from a reference meal containing B4 mg of isotopically labeled fortification iron. We analyzed data from baseline (n ¼ 1688) and intervention (n ¼ 727) studies in children in Morocco and India to look for associations between BMI Z-scores and baseline hemoglobin, serum ferritin and transferrin receptor, whole blood zinc protoporphyrin and body iron stores, and changes in these measures after provision of iron. Results: In the Thai women, 20% were iron deficient and 22% were overweight. Independent of iron status, a higher BMI Z-score was associated with decreased iron absorption (P ¼ 0.030). In the Indian and Moroccan children, 42% were iron deficient and 6.3% were overweight. A higher BMI Z-score predicted poorer iron status at baseline (Po0.001) and less improvement in iron status during the interventions (Po0.001). Conclusions: Adiposity in young women predicts lower iron absorption, and pediatric adiposity predicts iron deficiency and a reduced response to iron fortification. These data suggest the current surge in overweight in transition countries may impair efforts to control iron deficiency in these target groups. Interactions of the 'double burden' of malnutrition during the nutrition transition may have adverse consequences.

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“…It is worth mentioning that most of the studies reporting similar findings have used population-based samples of children and adolescents of a greater age range (10,12) or entirely clinically based study groups (25). Moreover, some authors investigated the relationships with the overall adiposity measures (25,27) or measured non-sensitive CRP (28).…”

Section: Discussionmentioning

confidence: 99%

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

Galcheva¹,

Iotova²,

Yotov

et al. 2011

European Journal of Endocrinology

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Objectives: To analyze the circulating levels of proinflammatory peptides in healthy prepubertal children in relation to abdominal obesity, measured by waist circumference (WC), and to investigate their interactions with cardiometabolic risk factors. Design and methods: A cross-sectional study of 137 healthy prepubertal children with a mean age of 8.0G0.1 years divided into three groups according to their WC as a measure of abdominal obesity: 'normal-WC' children (25th-75th percentile, nZ48), 'children at risk' (75th-90th percentile, nZ39), and 'abdominally obese' (R90th percentile, nZ50) children. Auxological measurements and blood pressure (BP) were taken. Fasting levels of high-sensitivity C-reactive protein (hsCRP), interleukin 6 (IL6), tumor necrosis factor-a (TNF-a), glucose, insulin, and lipid profile were measured. Insulin resistance (IR) was assessed by homeostasis model assessment of IR (HOMA-IR). Results: Abdominally obese children had significantly higher BP, insulin, HOMA-IR, total cholesterol and triglycerides (TG) compared with their normal-WC counterparts (P!0.05). HsCRP concentrations increased proportionally with the degree of abdominal obesity (rZ0.443, P!0.0001), whereas IL6 and TNF-a were not significantly associated with any of the adiposity variables. After controlling for adiposity, hsCRP was significantly correlated with systolic BP (rZ0.257, PZ0.004), TNF-a levels were related to high-density lipoprotein cholesterol (HDL-C; rZK0.216, PZ0.016) and TG (rZ0.196, PZ0.029), whereas the relationship between IL6 and HDL-C reduced its magnitude to an insignificant level (rZK0.173, PZ0.055). Conclusions: Healthy prepubertal children with abdominal obesity have associated inflammatory and cardiometabolic alterations, interacting with each other.

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Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men—the Third National Health and Nutrition Examination Survey

Cited by 181 publications

References 25 publications

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

Association between adiposity indicators, metabolic parameters and inflammatory markers in a sample of female adolescents

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

Circulating proinflammatory peptides related to abdominal adiposity and cardiometabolic risk factors in healthy prepubertal children

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