Association of Serum hs‐CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors

Ebrahimi, Mahmoud; Heidari‐Bakavoli, Alireza; Shoeibi, Sara; Mirhafez, Seyed Reza; Moohebati, Mohsen; Esmaily, Habibollah; Ghazavi, Hamed; Karimian, Maryam Saberi; Parizadeh, Seyed Mohammad Reza; Mohammadi, Maryam; Ardabili, Hossein Mohaddes; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.1002/jcla.21920

Cited by 74 publications

(60 citation statements)

References 15 publications

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“…Besides, the present study found significant direct correlation between hs-CRP and total cholesterol, triglycerides, LDL and inverse correlation between hs-CRP and HDL. These findings are in accordance with conclusions of Ebrahimi et al [35] who studied hs-CRP levels, as a marker of inflammation, in a large sample of population without a history of cardiovascular or inflammatory disease and cancer, and to relate this to fasting blood glucose (FBG) and the presence of diabetes mellitus.…”

Section: Discussionsupporting

confidence: 92%

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Kamel*

El-Baz

Emam

et al. 2020

Arab Journal of Nuclear Sciences and Applications

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Both diabetes and obesity are associated with chronic low-grade inflammation. IL-18 is a cytokine that stimulates various cell types and has pleiotropic functions. It is elevated in obesity, metabolic syndrome and type 2 diabetes (T2D).The hypothesis that serum level of IL-18 and high sensitive C-reactive protein can be used as markers for presence of chronic low-grade inflammation in type 2 diabetes more than in obesity per se was tested. The study recruited 80 subjects. They comprised 20 diabetic obese cases (DM-OB group), 20 diabetic non-obese cases (DM-NOB group), : 20 non-diabetic obese cases (NDM-OB group) and 20 non-diabetic non-obese subjects (NDM-NOB group). All participants were submitted to careful history taking, through clinical investigations and laboratory assessment. It was found that hs-CRP was significantly high in DMOB group (3.4±0.5 mg/dl) followed by NDM-OB group (2.9±0.4 mg/dl) then DM-NOB group (2.3±0.3 mg/dl) and least in NDM-NOB (0.8±0.3 mg/dl). It was also found that serum IL-18 was significantly highest in DMOB group (397.8±33.9 pg/mL) followed by NDM-OB (368.8±26.7 pg/mL) group followed by DM-NOB group (335.9±18.4 pg/mL) and least in NDM-NOB group (281.1±22.9 pg/mL). Serum IL-18 levels are directly correlated with BMI, waist circumference, hip circumference and waist/hip ratio in all the studied groups and with HbA1c in the diabetic groups. It could be concluded that Serum IL-18 and hs-CRP are related to diabetes and obesity. They are associated with dyslipidemia, poor glycemic control, insulin resistance and impaired liver and renal functions

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Section: Discussionsupporting

confidence: 92%

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Kamel*

El-Baz

Emam

et al. 2020

Arab Journal of Nuclear Sciences and Applications

View full text Add to dashboard Cite

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“…CRP is an inflammatory maker. Studies have been reported that CRP levels related insulin resistance with obesity . Risk of developing nonalcoholic fatty liver disease increased with a rising CRP level within the healthy cohort , and serum CRP levels decreased dramatically in obese subjects after bariatric surgery .…”

Section: Discussionmentioning

confidence: 99%

Impact of body fat percentage change on future diabetes in subjects with normal glucose tolerance

et al. 2017

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The aim of the work was to determine the effect of body fat change on risk of diabetes in normal glucose tolerance (NGT) population. A total of 1,857 NGT subjects were included and followed up for an average period of 44.57 months. Body fat percentage (BF%) was measured by bioelectrical impedance analysis. Subjects were grouped based on the BF% and/or body mass index (BMI) state. Among all subjects, 28 developed diabetes after follow-up. Compared with subjects with stable normal BF% (control), subjects who became obesity at follow-up were defects in insulin secretion and had a higher risk of developing diabetes (7.102, 95% confidence intervals [CI] 1.740-28.993), while no difference in diabetic risk could be viewed between subjects with abnormal BF% at baseline but normal at the end of follow-up and control subjects after adjustment of confounding factors. Moreover, compared with those keeping normal BF% and BMI both at baseline and follow-up, subjects who had normal BMI at baseline and follow-up, but abnormal BF% at baseline or/and follow-up still had a higher risk to develop diabetes (4.790, 95% CI 1.061-21.621), while those with normal BF% at baseline and follow-up, but abnormal BMI at baseline or/and follow-up had not. Subjects from normal BF% at baseline to obese at follow-up are associated with an increased risk of diabetes. Maintaining normal body fat is more relevant than BMI in preventing diabetes. © 2017 IUBMB Life, 69(12):947-955, 2017.

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“…Several studies were in agreement with our findings. For instance, Ebrahimi et al [25] performed a crosssectional study in order to evaluate the relationship between hs-CRP levels in presence of CVDs risk factors including DM, HTN and obesity. They recruited 7762 Iranian individuals with no previous history of cardiovascular events, malignancy or inflammatory disorders.…”

Section: Discussionmentioning

confidence: 99%

High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

Koosha

Roohafza

Sarrafzadegan

et al. 2020

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Association of Serum hs‐CRP Levels With the Presence of Obesity, Diabetes Mellitus, and Other Cardiovascular Risk Factors

Abstract: FBG, LDL-C, WC and gender are independently associated with serum hs-CRP concentrations.

Cited by 74 publications

References 15 publications

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Study of interleukin-18 ( IL18 ) and high sensitive C - reactive protein ( CRP ) in type 2 diabetes ( T2D ) with or without obesity

Impact of body fat percentage change on future diabetes in subjects with normal glucose tolerance

High Sensitivity C-Reactive Protein Predictive Value for Cardiovascular Disease: A Nested Case Control from Isfahan Cohort Study (ICS)

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