Association of serum omentin-1, apelin and chemerin concentrations with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients

Yasir, Md.; Senthilkumar, Gandhipuram Periyasamy; Jayashree, Kuppuswami; Babu, K Ramesh; Mehalingam, Vadivelan; Chinnakali, Palanivel

doi:10.1080/13813455.2019.1680698

Cited by 22 publications

(17 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a fat cytokine, Apelin plays an important role in various pathophysiological processes such as inflammatory response, immune response, cell growth and development, and apoptosis [16,31]. Recent studies have found that apelin can stimulate retinal endothelial cell proliferation and retinal neovascularization [32][33][34]. And previous studies have found that apelin receptor is highly expressed in the formation of embryonic blood vessels and the formation of retinal blood vessels in mice [35,36].…”

Section: Discussionmentioning

confidence: 99%

VEGF, apelin and HO-1 in diabetic patients with retinopathy: a correlation analysis

Zhu

Zhou

2020

BMC Ophthalmol

View full text Add to dashboard Cite

Background: It's necessary to analyze the role of VEGF, apelin, and HO-1 in patients with type 2 diabetes (T2DM), and to evaluate its relevance to diabetic retinopathy (DR). Methods: T2DM patients who were treated in our hospital from December 1, 2018 to November 30, 2019 were included. T2DM patients were divided into non-DR (NDR) group, non-proliferative DR (NPDR) group, and proliferative DR (PDR) group. and healthy participants were selected as the control group. The value of VEGF, apelin, and HO1 in predicting PDR were analyzed by receiver operating characteristic (ROC) curve, and the relations of VEGF, apelin, HO-1 and clinical factors in PDR patients were analyzed by Pearson correlation analysis. Results: A total of 295 participants were included. The level of FPG and HbAlc in PDR group were significantly higher than that of other groups (all p < 0.05); the level of VEGF and apelin in PDR group were significantly higher than that of other groups (all p < 0.05), but the level of HO-1 in PDR group were significantly less than that of other groups(p = 0.017); the AUC of VEGF, apelin, HO-1 and combined use was 0.806(95%CI: 0.779-0.861), 0.819(95%CI: 0.765-0.878), 0.808(95%CI: 0.733-0.869) and 0.902(95%CI: 0.822-0.958) respectively, the AUC, sensitivity, specificity of the three combined use was significantly higher than that of single VEGF, apelin, HO-1 use(all p < 0.05). The cutoff values of serum VEGF, apelin, and HO-1 levels for predicting PDR were 163.85 pg/ml, 8.27 ng/ml, and 26.06 mmol/L respectively. Serum VEGF, apelin, and HO-1 in patients with PDR was related to the time course of DM, FPG and HbAlc (all p < 0.05). Conclusions: VEGF, apelin and HO-1 are related to the progress of DR, and the combined use of VEGF, apelin and HO-1 is beneficial to the diagnosis and treatment of PDR.

show abstract

Section: Discussionmentioning

confidence: 99%

VEGF, apelin and HO-1 in diabetic patients with retinopathy: a correlation analysis

Zhu

Zhou

2020

BMC Ophthalmol

View full text Add to dashboard Cite

show abstract

“…Obviously, aerobic exercise can be used to increase omentin-1 levels in patients with diabetes, while drug interventions have an inhibitory effect. Some studies have reported a decrease in omentin-1 levels in prediabetes [5]. A possible explanation for this phenomenon is that because omentin-1 may increase insulin sensitivity, its decrease may cause impaired glucose homeostasis in patients with prediabetes.…”

Section: Discussionmentioning

confidence: 99%

“…Thickening of the intima-media is associated with other risk factors for cardiovascular disease (myocardial infarction, stroke, sudden death, smoking, dyslipidemia, hypertension, etc.) [5]. Several studies have shown the association of intima-media thickening with the development of metabolic syndrome and DM [6].…”

Section: Introductionmentioning

confidence: 99%

Omentin Metabolism and Pathophysiological Relationship Between Its Level and the Severity of Lesions in the Intima-Media Thickness of the Carotid Arteries in Type 2 Diabetes Mellitus in Combination With Obesity

Kulynych

Soloviuk

2020

Technology transfer: innovative solutions in medicine

View full text Add to dashboard Cite

The relationship of visceral obesity and excess body weight (EBW) with the development of cardiovascular diseases, type 2 diabetes mellitus (DM) and effect on quality and duration of life determine the relevance of studying this problem. The aim: to assess omentin-1 metabolism and pathophysiological relationship between its level and the severity of lesions in the intima-media thickness (IMT) of the carotid arteries in type 2 DM in combination with EBW and obesity. Materials and methods. We examined 98 people with DM, the first group consisted of 64 people with EBW and obesity, second group consisted of 34 people with normal body weight, control group – 28 healthy individuals. The concentration of omentin-1 was investigated by ELISA by solid-phase enzyme-linked immunosorbent assay in vitro. Ultrasound of the carotid arteries was performed in the lying position of the patient on the device MyLab50X with a linear sensor of 7 MHz with a slight deviation of the patient's head in the opposite direction. Results. Evaluation of the correlation matrix showed the presence of a positive rather strong negative connection between IMT, especially the right carotid artery and the level of omentin-1 in the blood (Rs = –0.55; p = 0.002). The largest number of individuals with omentin-1 levels from 5–10 ng / ml had significant disorders of the vascular wall (IMT from 1.0 to 1.2 mm). Conclusion. Obtained data indicate a statistically significant associative relationship between the dynamics of the predictor of cardiovascular risk – IMT with the degree of impaired expression of omentin-1.

show abstract

“…Yilmaz et al 6 suggested that adiponectin might take part in the pathogenesis of DR. Uckaya et al 7 declared that the more advanced the DR, the higher the plasma leptin levels, suggesting leptin might play a role in the progression of human DR to a proliferative phase. In addition, circulating visfatin was increased with progressive b-cell deterioration 8 , and serum omentin-1 concentration correlated negatively with DR presence and severity in type 2 diabetes mellitus patients 9 . Jung et al 10 found that higher serum adiponectin was related to increased odds for diabetic nephropathy in type 2 diabetes mellitus.…”

Section: Introductionmentioning

confidence: 94%

Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus

Yang

Huang

Gai

et al. 2020

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/Introduction: Vaspin is linked to obesity and its metabolic abnormalities. However, the role of vaspin serum levels in diabetic retinopathy (DR) is unknown. In the present study, we investigated the association between serum levels of vaspin and both DR and vision-threatening DR. Materials and Methods: This was a cross-sectional single-center observational study from December 2018 to September 2019. We evaluated circulating serum levels of vaspin in 372 participants with type 2 diabetes. DR was screened through detailed ocular examination. DR patients were also divided two groups: vision-threatening DR and non-visionthreatening DR. The relationship between vaspin and DR was investigated by univariate and multivariate logistic regression analyses, and the results are shown as odds ratios with 95% confidence intervals. Results: The vaspin serum levels of 372 patients were obtained, with a median value of 1.50 ng/mL (interquartile range 0.94-2.18 ng/mL). The median age of those patients was 53 years (interquartile range 44-62 years), and 44.4% were women. Patients with DR and VDTR had significantly increased vaspin serum levels (P < 0.001 and P < 0.001). A multivariable regression model found that patients with high levels of vaspin were approximately 1.85-fold (odds ratio for per unit increase 1.85, 95% confidence interval 1.43-2.55; P < 0.001) more likely to experience DR, and 3.76-fold (odds ratio for per unit increase 3.76, 95% confidence interval 2.05-6.55; P < 0.001) more likely to experience VTDR. The predictive value of vaspin was stronger in women than in men. Conclusion: Higher vaspin serum levels were associated with an increased risk of DR and VDTR in patients with type 2 diabetes, which showed that vaspin is an important indicator factor for DR.

show abstract

Association of serum omentin-1, apelin and chemerin concentrations with the presence and severity of diabetic retinopathy in type 2 diabetes mellitus patients

Cited by 22 publications

References 49 publications

VEGF, apelin and HO-1 in diabetic patients with retinopathy: a correlation analysis

VEGF, apelin and HO-1 in diabetic patients with retinopathy: a correlation analysis

Omentin Metabolism and Pathophysiological Relationship Between Its Level and the Severity of Lesions in the Intima-Media Thickness of the Carotid Arteries in Type 2 Diabetes Mellitus in Combination With Obesity

Serum vaspin levels are positively associated with diabetic retinopathy in patients with type 2 diabetes mellitus

Contact Info

Product

Resources

About