Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population

Ni, Wenqing; Wang, Rui; Liu, Zhen; Yuan, Xiaojie; Chi, Hongshan; Lv, Deliang; Sun, Yuanying; Liu, Peng; Xu, Jin

doi:10.1089/met.2019.0043

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…Interestingly, serum uric acid concentration decreased significantly after weight reduction only in the MR group. Besides dietary risk factors such as consumption of animal-derived purine-rich foods, legumes, and alcoholic beverages [ 31 , 32 , 33 ], serum uric acid concentration is known to be associated with metabolic syndrome [ 34 , 35 ]. Many studies have shown that serum uric acid is also associated with the risk for developing NAFLD [ 36 , 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Siener

Ernsten

Bitterlich³

et al. 2022

Nutrients

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Overweight has been suggested to increase the risk of kidney stone formation. Although weight reduction might affect risk factors for urolithiasis, findings on the impact of different dietary weight loss strategies are limited. This randomized, controlled study evaluated the effect of a conventional energy-restricted modified diet with (MR group) or without meal replacement (C group) on risk factors for stone formation in overweight women without a history of urolithiasis. Of 105 participants, 78 were included into the per-protocol analysis. Anthropometric, clinical, biochemical, and 24 h urinary parameters were collected at baseline and after 12 weeks. Although both dietary interventions resulted in a significant weight reduction, relative weight loss and rate of responders were higher in the MR group. Weight loss improved cardiometabolic risk profile in both groups. Unfortunately, the benefit of decreased GPT activity in the C group was offset by a significant increase in homocysteine and a decline in GFR. While the relative supersaturation of calcium oxalate decreased significantly in both groups, a significant decline in serum uric acid concentration and relative supersaturation of uric acid was observed only in the MR group. Finally, the energy-restricted modified diet with meal replacement showed significant advantages over the energy-restricted modified diet alone.

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Section: Discussionmentioning

confidence: 99%

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Siener

Ernsten

Bitterlich³

et al. 2022

Nutrients

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“…15 Recent studies found that an increase in serum UA levels was closely related to the occurrence of metabolic syndromes other than gout, such as dyslipidaemia, abnormal glucose tolerance, hypertension, central obesity and other metabolic disorders. 16 UA also induces insulin resistance via endothelial cell mitochondrial oxidative stress. 17 The relationship between UA and IGF-1 has received some attention, but there is little research on this relationship.…”

mentioning

confidence: 99%

Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

Liu¹,

Wang²,

Zhao³

et al. 2021

IJGM

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Objective: This research examined the relationship between uric acid (UA) and insulin-like growth factor-1 (IGF-1) in patients with type 2 diabetes mellitus (T2DM). Methods: This study was a cross-sectional study that included 1230 Chinese patients with T2DM. We collected general information and laboratory indicators and calculated the standard deviation score of IGF-1 (IGF-1 SDS). Results:The univariate analysis results demonstrated a significant positive relationship between UA levels and IGF-1 SDS (P<0.001). A nonlinear relationship was discovered between UA and IGF-1 SDS after adjusting for confounding factors. Multivariate piecewise linear regression showed that the levels of IGF-1 SDS increased when UA was <4.17 mg/dl (β 0.12,95% CI −0.04, 0.28; P=0.121) and decreased when UA was >4.17 mg/dl (β −0.38,95% CI −0.64, −0.12; P=0.004). Conclusion:This study showed a nonlinear relationship between UA and IGF-1 in Chinese adults with T2DM. When the UA levels reached the inflection point, IGF-1 levels negatively correlated with the increase in UA. Further studies are needed to explore this relationship and mechanisms in the future.

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“…SERUM URIC ACID (SUA) levels are positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, and hyperlipidemia [1]. Elevated SUA levels are independently correlated with the incidences of hypertension and metabolic syndrome (MetS) in some Asian countries including China, Japan, and Korea [2][3][4][5]. For patients with type 2 diabetes mellitus (T2DM), higher SUA levels are associated with the lower estimated glomerular filtration rate (eGFR) and higher prevalence of diabetic nephropathy, but not diabetic retinopathy [6].…”

mentioning

confidence: 99%

Correlation between serum C-peptide-releasing effects and the risk of elevated uric acid in type 2 diabetes mellitus

et al. 2022

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Our study aimed to investigate the C-peptide-releasing effect associated with the risk of elevated serum uric acid (SUA) levels in patients with type 2 diabetes mellitus (T2DM). In the cross-sectional study, 345 patients with T2DM hospitalized at the First Affiliated Hospital of Harbin Medical University were consecutively enrolled, and their baseline data were collected. The study design used two parameters for C-peptide releasing effects: the multiplication effect of 1 h postprandial C-peptide to fasting C-peptide ratio (1hCp/FCp) and 2hCp/FCp; the incremental effect of 1hCp minus FCp (1hΔCp) and 2hΔCp. The patients with T2DM in the upper quartiles of SUA had higher FCp, 1hCp, 1hΔCp, 2hCp, and 2hΔCp. Multiple linear regression analysis revealed that after adjusting all the confounding factors, the serum C-peptide including 1hCp (β = 5.14, p = 0.036), 1hΔCp (β = 7.80, p = 0.010), 2hCp (β = 4.27, p = 0.009) and 2hΔCp (β = 5.20, p = 0.005) were still positively correlated with SUA levels in patients with T2DM. In female patients, only the 2hCp (β = 4.78, p = 0.017) and 2hΔCp (β = 5.28, p = 0.019) were associated with SUA level; however, in male patients, no C-peptide parameter was associated with SUA levels in T2DM (all p > 0.05). Within a certain range, the elevated SUA levels might be associated with the better C-peptide incremental effect of islet β cell function in T2DM, especially in female patients.

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Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Cross-Sectional Study in Chinese Coastal Population

Cited by 10 publications

References 33 publications

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Effect of Two Different Dietary Weight Loss Strategies on Risk Factors for Urinary Stone Formation and Cardiometabolic Risk Profile in Overweight Women

Association Between Uric Acid and Insulin-Like Growth Factor-1 in Type 2 Diabetes Mellitus

Correlation between serum C-peptide-releasing effects and the risk of elevated uric acid in type 2 diabetes mellitus

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