Association of serum uric acid with all-cause and cardiovascular mortality in obstructive sleep apnea

Yang, Zhe; Lv, Tian; Lv, Xiaoheng; Wan, Fangyuan; Zhou, Hong; Wang, Xiaoling; Zhang, Lisan

doi:10.1038/s41598-023-45508-2

Cited by 4 publications

(1 citation statement)

References 33 publications

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“…One meta-analysis also reported that individuals with OSA had higher serum uric acid levels compared to the control group [27]. Moreover, serum uric acid was associated with all-cause mortality and cardiovascular mortality in individuals with OSA which was determined using the NHANES screening questionnaire [28]. A bidirectional two-sample Mendelian randomization study was conducted using data from publicly available genome-wide association study summary statistics [29].…”

Section: Discussionmentioning

confidence: 99%

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

Park,

Lim,

Lee

2024

JPM

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Upper airway collapse and apneas in obstructive sleep apnea (OSA) induce intermittent hypercapnia and hypoxia, eventually contributing to excessive uric acid production. This study aimed to evaluate the association between hyperuricemia and OSA in the general population via analysis of the eighth KNHANES dataset (2019–2021). OSA risk was identified via the STOP-Bang questionnaire, with a score ≥3 indicating high risk. Among 11,981 total participants, 4572 (38.2%) had a high OSA risk. Participants with a high OSA risk had higher uric acid levels compared to those with a low risk (5.5 ± 1.4 mg/dL vs. 4.8 ± 1.2 mg/dL, p < 0.001). Serum uric acid levels were positively correlated with STOP-Bang score (r: 0.317, p < 0.001). Multivariate analysis revealed that hyperuricemia was associated with a high OSA risk after adjusting for confounders (odds ratio: 1.30, 95%CI: 1.11–1.53, p = 0.001). Therefore, serum uric acid levels are significantly higher in those with a high OSA risk and correlate with the risk of OSA. Further, hyperuricemia is an independently associated risk factor for high OSA risk. More research is warranted to evaluate the long-term clinical outcomes of hyperuricemia in OSA and to determine whether treatment targeting hyperuricemia is effective in the clinical course of OSA.

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Section: Discussionmentioning

confidence: 99%

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

Park,

Lim,

Lee

2024

JPM

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A cross-sectional study of the correlation of the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) with obstructive sleep apnea (OSA) in adult populations: NHANES (2005–2008 and 2015–2020)

Zhang,

Hu,

Zhang

et al. 2024

Medicine

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The ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol, abbreviated as NHHR, represents a brand-new lipid biomarker for assessing cardiovascular disease risk. Research has suggested a link between lipid metabolism and obstructive sleep apnea (OSA). To delve deeper, this study was carried out using data derived from the NHANES to ascertain whether NHHR and OSA are associated. In this research, a cross-sectional analysis was executed based on data derived from NHANES across the years 2005 to 2008 and 2015 to 2020. After adjusting for confounders such as demographic characteristics, lifestyle, and health status, the link between NHHR and the likelihood of developing OSA was examined via weighted binary logistic regression as well as restricted cubic spline (RCS) models. In addition, subgroup analysis was completed to check if the obtained results were reliable. The study included 16,265 adult participants. Following comprehensive adjustment for confounders, results obtained suggested that, for each additional unit increment of NHHR, there is a 9% increased chance of developing OSA. Compared to the lowest quartile, the highest quartile of NHHR notably increased the risk of developing OSA in the overall population (OR: 1.65; 95% CI: 1.38–1.98; P < .001). The RCS curve indicated a linear positive correlation between NHHR and OSA, which remained significant in subsequent subgroup analyses (all P for interaction > .05). This suggested that the correlation between NHHR and OSA was stable across populations with different characteristics. Confounders such as demographics, lifestyle, and health status did not significantly affect this positive correlation. Findings from this study uncovered a strong connection between NHHR and an increased possibility of developing OSA in American adults. Further exploration of NHHR could offer insights into OSA prevention and treatment. However, owing to the constraints inherent in cross-sectional studies, more studies are required to establish a concrete link between NHHR and OSA.

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The relationship between obstructive sleep apnea and osteoarthritis: evidence from an observational and Mendelian randomization study

Yang,

Lv,

Jin

et al. 2024

Front. Neurol.

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ObjectivesObstructive sleep apnea (OSA) and osteoarthritis (OA) are common comorbidities that significantly impact individuals’ quality of life. However, the relationship between OSA and OA remains unclear. This study aims to explore the connection between OSA and OA and evaluate causality using Mendelian randomization (MR).MethodsA total of 12,454 participants from the National Health and Nutrition Examination Survey (2009–2012) were included. OSA participants were identified based on self-reported interviews. The association between OA and OSA was assessed through multivariable logistic regression analysis. A two-sample MR was employed to investigate the relationship between OSA and OA, specifically hip OA and knee OA, utilizing the inverse variance-weighted (IVW) approach.ResultsBased on the observational study, individuals with OSA exhibited a higher risk of OA (OR = 1.67, 95% CI = 1.40–1.98). IVW demonstrated that the risk of OA (OR = 1.13, 95% CI: 1.05–1.21, p = 0.001), hip OA (OR = 1.11, 95% CI: 1.04–1.18, p = 0.002), and knee OA (OR = 1.08, 95% CI: 1.02–1.14, p = 0.005) was significantly associated with OSA. Reverse MR analyses indicated no effect of OA on OSA. Additionally, body mass index (BMI) was found to mediate 36.9% (95% CI, 4.64–73.2%, p = 0.026) of the OSA effects on OA risk.ConclusionThe cross-sectional observational analysis unveiled noteworthy associations between OSA and OA. Meanwhile, findings from the MR study provide support for a causal role.

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Association of serum uric acid with all-cause and cardiovascular mortality in obstructive sleep apnea

Cited by 4 publications

References 33 publications

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

The Association of Serum Uric Acid with Risk of Obstructive Sleep Apnea: The Korean National Health and Nutrition Examination Survey 2019–2021

A cross-sectional study of the correlation of the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) with obstructive sleep apnea (OSA) in adult populations: NHANES (2005–2008 and 2015–2020)

The relationship between obstructive sleep apnea and osteoarthritis: evidence from an observational and Mendelian randomization study

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