Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis

Su, Mei Tsz; Lin, Sheng Hsiang; Chen, Yi Chi

doi:10.1016/j.fertnstert.2011.09.030

Cited by 41 publications

(26 citation statements)

References 55 publications

(64 reference statements)

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“…Recently, a number of genetic polymorphisms have been investigated by meta-analysis for association with RPL, in genes such as the sex hormone receptor gene [18], the vascular endothelial growth factor (VEGF) gene, the p53 gene, endothelial nitric oxide synthase (eNOS) gene [19], 1082/interleukin-10 (IL-10) gene [20], and the MTHFR gene [21]. However, there have been no meta-analyses describing the ACE I/D polymorphism association with RPL.…”

Section: Diseasementioning

confidence: 99%

“…In addition, the definitions of the maternal ages in every study have some potential differences. However, it is said that maternal age is one of the factors that can enhance the effect of genetic polymorphisms [18]. Therefore, the factors mentioned above might lead to the selection bias, which was a possible major source of heterogeneity resulting from non-systemic samples, creating some deviation.…”

Section: Limitationsmentioning

confidence: 99%

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Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2012

J Assist Reprod Genet

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Background Recurrent pregnancy loss (RPL) had said to be related to the angiotensin converting enzyme insertion/deletion polymorphisms (ACE I/D) gene polymorphisms. But the conclusions were controversial. This meta-analysis was conducted to investigate the real association in ACE I/D polymorphisms and RPL firstly. Methods Combine Pubmed Embase and HuGENet database in data analysis for this meta-analysis from October 2000 to November 2011. The metagen system was used to select the models and effects. Odds ratio (OR) with 95% confidence interval (CI) was used to assess the strength of this association. Results 9 studies from six countries with 1264 RPL and 845 controls were included according to our criterion. Following the metagen system, we used the dominant model with random effects. The summary OR 01.61 (95% CI: 1.10-2.36, I 2 0 59.0%), which suggested the ACE D allele might increase the RPL risk in Asia (OR01.97, 95% CI: 1.31-2.98, I 2 0 44.4%), among Asians (OR01.69, 95% CI: 1.06-2.36, I 2 032.7%). In additional, after conducting sensitivity analysis, the results had no differences except for Caucasian subgroup reached to the significance (OR02.059, 95% CI: 1.455-2.914), so we couldn't ignore the relationship between the polymorphisms of ACE D/I gene and Caucasians yet. There seemed no publication bias in our eligible studies with Begg's test (P 0 0.867). Conclusions Results in this meta-analysis presented the positive function of the ACE I/D polymorphism in increasing the RPL risk. Furfure prospective studies were needed to confirm the precise relationship between the ACE I/D and RPL.

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Section: Diseasementioning

confidence: 99%

Section: Limitationsmentioning

confidence: 99%

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Chen

et al. 2012

J Assist Reprod Genet

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“…RM is a challenging clinical condition notable for a multifactorial etiology, and that up to 50% of cases remain undetermined even after detailed clinical examination (Li et al 2002). In patients with idiopathic RM, gene polymorphisms have been proposed as susceptibility factors that increase the risk of miscarriage when compared with otherwise healthy women (Su et al 2011a(Su et al , 2011b.…”

Section: Introductionmentioning

confidence: 99%

Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy

Su¹,

Lin²,

Chen³

et al. 2013

Reproduction

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Endocrine gland-derived vascular endothelial growth factor (EG-VEGF) and its receptor genes (PROKR1 (PKR1) and PROKR2 (PKR2)) play an important role in human early pregnancy. We have previously shown that PROKR1 and PROKR2 are associated with recurrent miscarriage (RM) using the tag-SNP method. In this study, we aimed to identify PROKR1 and PROKR2 variants in idiopathic RM patients by genotyping of the entire coding regions. Peripheral blood DNA samples of 100 RM women and 100 controls were subjected to sequence the entire exons of PROKR1 and PROKR2. Significant non-synonymous variant genotypes present in the original 200 samples were further confirmed in the extended samples of 144 RM patients and 153 controls. Genetic variants that were over-or underrepresented in the patients were ectopically expressed in HEK293 and JAR cells to investigate their effects on intracellular calcium influx, cell proliferation, cell invasion, cell-cell adhesion, and tube organization. We found that the allele and genotype frequencies of PROKR1 (I379V) and PROKR2 (V331M) were significantly increased in the normal control groups compared with idiopathic RM women (P!0.05). PROKR1 (I379V) and PROKR2 (V331M) decreased intracellular calcium influx but increased cell invasiveness (P!0.05), whereas cell proliferation, cell-cell adhesion, and tube organization were not significantly affected. In conclusion, PROKR1 (I379V) and PROKR2 (V331M) variants conferred lower risk for RM and may play protective roles in early pregnancy by altering calcium signaling and facilitating cell invasiveness.

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“…Рецепторна відповідь на прогестерон може залежати від однонуклеотидного полімор-фізму (SNP) PGR [11,12]. Станом на 2016 р. описано 5732 поліморфізмів PGR, проте за останні роки було проведено лише декілька досліджень, які вказують на роль SNPs PGR у формуванні схильності до виникнення звичного невиношування вагітності [11][12][13][14][15][16]. SNPs PGR може спричиняти порушення експресії PGR, тим самим змінюючи перебіг біохімічних процесів в організмі жінки і сприяючи розвитку патологічного процесу та/або впливати на перебіг останнього [12].…”

Section: вступunclassified

Progesterone Receptor Gene Polymorphisms as Genetic Risk Factor of Threatened Abortion

Kryvopustov¹,

Dosenko²

2016

Fiziol Zh

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Визначення поліморфізмів гена рецептора прогестерону rs590688 C/G та rs500760 A/G проведено з використанням методу полімеразної ланцюгової реакції в реальному часі у вагітних жінок із загрозою аборту (дослідна група) та у практично здорових вагітних жінок (контрольна група). За результатами генотипування розподіл алельних варіантів значно відрізнявся при дослідженні

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Association of sex hormone receptor gene polymorphisms with recurrent pregnancy loss: a systematic review and meta-analysis

Cited by 41 publications

References 55 publications

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Angiotensin-converting enzyme insertion/deletion (I/D) polymorphisms and recurrent pregnancy loss: a meta-analysis

Prokineticin receptor variants (PKR1-I379V and PKR2-V331M) are protective genotypes in human early pregnancy

Progesterone Receptor Gene Polymorphisms as Genetic Risk Factor of Threatened Abortion

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