Association of Simvastatin and Hyperlipidemia With Periodontal Status and Bone Metabolism Markers

Abstract

Within the limits of this study, the findings suggest that the intake of simvastatin is associated with increasing serum OPG concentrations, and this could have a protective effect against bone breakdown and periodontal attachment loss. The baseline systemic inflammatory state of patients with hyperlipidemia is indicated by their increased erythrocyte sedimentation rate.

Effect of hyperlipidemia on response to nonsurgical periodontal therapy: Statin users versus nonusers

“…A recent research observed that hyperlipidemic patients on statin treatment had higher levels of the bone protective biomarker osteoprotegerin as compared to hyperlipidemic nonstatin users. [ 32 ] In the same study, statin users also displayed a mean decrease of 0.8 mm in CAL as compared to NL control subjects. In the retrospective cohort study by Cunha-Cruz et al .,[ 14 ] it was reported that statin consumption in the 3 years interval after initial periodontal evaluation resulted in significantly decreased the risk of tooth loss.…”

Association between periodontitis and blood lipid levels in a Korean population

“…A recent study, based on the U.S. National Health and Nutrition Examination Survey, found a significant association between borderline to high levels of serum total cholesterol and periodontitis. Furthermore, treatment for hyperlipidemia had a protective effect against periodontal attachment loss …”

The Association Between Dental Status and Systemic Lipid Profile and Inflammatory Mediators in Patients After Myocardial Infarction

“…The results of scientific research on LDL-C concentration in the blood of patients with CVD depending on the state of periodontal tissues are ambiguous [16,17]. However, the majority of reports on patients without cardiovascular burden indicate an impact of periodontitis on lipid disorders expressed by elevated levels of LDL-C, TC and TG, and a reduced level of HDL-C [3,[18][19][20]. Most recently, Sangwan et al [18] observed positive and significant correlations between PD and TG, TC and LDL-C serum concentrations, as well as between CAL and TC, and CAL and LDL-C, after adjusting for confounders.…”