Association of single-nucleotide polymorphisms in the IL27 gene with autoimmune thyroid diseases

Abstract

Background Accumulating data have shown that interleukin-27 (IL27) polymorphisms are linked to the susceptibility of some autoimmune diseases. We assessed whether there was an association between three single-nucleotide polymorphisms (SNPs) of IL27 gene and autoimmune thyroid diseases (AITDs). Methods Three SNPs (rs153109, rs17855750 and rs181206) of IL27 gene were genotyped by Hi-SNP high-throughput genotyping in 843 patients with AITDs (516 Graves’ disease (GD) and 327 Hashimoto’s thyroiditis (HT)) and 677 healthy controls in Chinese Han population. Results Compared with controls, rs153109 displayed significant associations with GD in allele and genotype frequencies (P = 0.002 and P = 0.008, respectively) and rs17855750 displayed significant associations with HT in allele frequencies (P = 0.02), whereas no differences in genotype or allele frequencies were found between AITD patients and controls at rs181206. Conclusion Our study, for the first time, showed the significant association of the IL27 gene SNPs with AITD.

Sirtuin 1, Visfatin and IL-27 Serum Levels of Type 1 Diabetic Females in Relation to Cardiovascular Parameters and Autoimmune Thyroid Disease

“…IL-27 most likely enhances Th1 lymphocyte function and suppresses Th2, which would suggest an immune imbalance similar to that seen in T1DM or HD [49]. In line with this assumption, studies of single nucleotide polymorphisms have confirmed an association between IL-27 [50] and the SIRT1 gene with autoimmune thyroid diseases [51]. In this study, aTG was positively correlated with the IL-27 serum levels in women with T1DM, but not significantly with sirtuin 1 serum levels.…”

IL-30† (IL-27A): a familiar stranger in immunity, inflammation, and cancer

“…Furthermore, the multiple pairings of IL-30 and roles for IL-30 in human immunity may suggest that we do not appreciate the full picture of human IL-30 secretion and functions yet. As an example, polymorphisms in the IL-30 gene have been reported in numerous disease settings, including premature coronary artery disease 100 , bladder cancer 101 , osteosarcoma 102 , asthma 103 , autoimmune thyroid disease 104 , and IBD 105 . Whether these mutations alter the folding and secretion pattern of IL-30 or one of its pairings remains to be determined.…”

Long non‐coding RNA CASC8 polymorphisms are associated with the risk of esophageal cancer in a Chinese population

“…Genomic DNA samples were isolated using the QIAamp DNA Blood Mini Kit (Qiagen, Berlin, Germany) 27 and the extracted DNA sample was amplified by polymerase chain reaction (PCR). Hi‐SNP high‐throughput genotyping methods 28 were used to genotype the amplification products (Shanghai Biowing Applied Biotechnology CO. LTD, Shanghai, China).…”