Association of Single-Nucleotide Polymorphisms of Gab1 Gene with Susceptibility to Meningioma in a Northern Chinese Han Population

Abstract

Background The Gab1 gene has an important role in cell proliferation in meningioma via various signaling pathways. However, the relationship between polymorphisms of the Gab1 gene and meningioma remains unknown. In this study, we aimed to investigate the plausible association of single-nucleotide polymorphisms (SNPs) of the Gab1 gene and meningioma risk in a northern Chinese Han population. Material/Methods This case-control study included 205 patients with meningioma and 297 healthy controls. Four loci of the Gab1 gene were genotyped using the multiplex snapshot technique. The odds ratio (OR) and 95% confidence interval (CI) were calculated by chi-squared and logistic regression analysis. The distributions of Gab1 SNP genotypes and allele frequencies were compared between patients with meningioma and healthy controls and among patients stratified by clinical phenotypes. Results The allelic frequency distributions of G at rs3805236 and C at rs1397529 were significantly higher in patients with meningioma than in healthy controls. The frequency of the rs3805236-GG and rs1397529-AC genotypes were significantly higher in patients with meningioma than in controls. Furthermore, there was a statistically significant difference between the genotypes of patients versus healthy individuals at rs1397529, according to stratification by dural invasion. The allelic frequency distributions of alleles or genotypes at rs3805246 and rs3828512 were not different in patients with meningioma and healthy controls. Conclusions The Gab1 gene rs3805236A>G and rs1397529A>C SNPs increased the risk of meningioma in the northern Chinese Han population. Furthermore, rs1397529A>C may be related to enhanced dural invasion in patients with meningioma.

Association of GAB1 gene with asthma susceptibility and the efficacy of inhaled corticosteroids in children

“…By contrast, in the current study no difference in the distribution of genotypes and alleles of rs3805236 between asthma and control groups were discovered, implying that rs3805236 may not represent a susceptibility locus for asthma in Chinese children, and we consider that it might be affected by regional ethnicity. Previous studies have validated the association of rs3805246 with meningioma, cholangiocarcinoma, and gastritis [25][26][27]. However, there is currently no correlation study between this locus and childhood asthma, and our study revealed no link between this locus and childhood asthma susceptibility.…”

The Role of GAB1 in Cancer

“…GAB1 germline copy number variation is linked to breast cancer risk [ 75 ]. Furthermore, genetic polymorphisms in GAB1 have been reported to increase susceptibility to developing some types of cancer, such as cholangiocarcinoma, meningiomas, and lung cancer [ 76 , 77 , 78 , 79 ]. Interestingly, high levels of GAB1 expression are associated with poor prognosis in patients with gliomas, hepatocellular carcinoma, and ovarian cancer [ 80 , 81 , 82 ].…”