Association of smoking and physical inactivity with MRI derived changes in cardiac function and structure in cardiovascular healthy subjects

Schafnitzel, Anina; Lorbeer, Roberto; Bayerl, Christian; Patscheider, H.; Auweter, Sigrid; Meisinger, Christa; Heier, Margit; Ertl‐Wagner, Birgit; Reiser, Maximilian; Peters, Annette; Bamberg, Fabian; Hetterich, Holger

doi:10.1038/s41598-019-54956-8

Cited by 12 publications

(9 citation statements)

References 46 publications

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“…Previous studies have shown that the level of physical activity [22], smoking [23] and the left ventricular hypertrophy [12,24] affect the right ventricle. It was previously shown that healthy residents of highlands have small left heart and large right ventricle due to exposure to hypoxemia at high altitudes, and these changes did not depend on ethnicity [25].…”

Section: Discussionmentioning

confidence: 99%

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Сумин

Gomozova

Щеглова

et al. 2022

Preprint

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Objective of this study was to compare right ventricular echocardiography parameters in urbanized hypertensive patients of the Shor and non-indigenous ethnic groups in the Mountain Shoria region. Methods The study included patients with arterial hypertension: 58 Shors and 50 non-indigenous urbanized residents, comparable in age, and divided by ethnicity and gender into 4 groups: Shors men (n = 20), Shors women (n = 38), non-indigenous men (n = 15) and non-indigenous women (n = 35). All underwent echocardiographic examination, and the right heart parameters were studied. Results Shor men with arterial hypertension had the lowest values of the pulmonary artery index, the right atrium dimensions, and the highest values of the blood flow velocity in the right ventricle, et' and st' in comparison with non-indigenous men. Shor women have the lowest values Et and Et/At ratios. RV diastolic dysfunction was detected mainly in women, somewhat more often in Shors. Ethnicity was one of the factors associated with the right ventricular diastolic dysfunction presence. Among the factors associated with the RV diastolic dysfunction were risk factors (smoking, obesity), blood pressure, gender, ethnicity, and left ventricular parameters (diastolic dysfunction and the myocardial mass increase). Conclusion Our study established the influence of ethnic differences on the right heart echocardiographic parameters in Shors and Caucasians with arterial hypertension. The revealed differences should improve the assessment of the right heart structure and function in patients with arterial hypertension from small ethnic groups, which will help to improve the diagnosis and treatment of such patients.

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Section: Discussionmentioning

confidence: 99%

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Сумин

Gomozova

Щеглова

et al. 2022

Preprint

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“…Conversely, the practice of smoking was associated with a 70% reduction in aerobic capacity. The deleterious effects of smoking on aerobic fitness are well established by science; however, it should be noted that smoking is also an independent risk factor for cognitive decline [ 26 ] and has important deleterious effects on the cardiac structure and function [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Functional Capacity, Lipid Profile, and Associated Factors in Older Adults Living in Urban and Rural Areas

Medeiros

Sá

Chielle

et al. 2022

Journal of Aging Research

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This study aimed to analyze the relationship between sociodemographic and lifestyle variables, functional strength, aerobic capacity, and lipid profile of older adults living in urban and rural areas. For this purpose, 208 older adults were evaluated (132 living in rural areas and 73 living in urban areas). Sociodemographic data were collected, and functional strength, aerobic capacity, and lipid profile of older adults living in the southern region of Brazil were evaluated. Only total cholesterol and LDL cholesterol were associated with place of residence ( p < 0.05 ), and living in the countryside was associated with low aerobic capacity ( p = 0.010 ). The use of medication (OR = 3.01; p = 0.012 ) and smoking (OR = 0.30; p = 0.027 ) were the only variables that explained aerobic performance, regardless of place of residence. In conclusion, place of residence is not a factor that, alone or in combination with other conditions, affects the functional performance or lipid profile of the older adult population.

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“…For the main analyses, we investigated CMR parameters that were most strongly correlated with CVD risk factors in previous studies of this sample (LV: end-diastolic volume, stroke volume, diastolic myocardial mass, early diastolic filling rate; RV: end-diastolic volume, stroke volume; fat: epicardial, diastolic) [ 14 , 16 – 18 ].…”

Section: Methodsmentioning

confidence: 99%

Association of antecedent cardiovascular risk factor levels and trajectories with cardiovascular magnetic resonance-derived cardiac function and structure

Lorbeer

Rospleszcz

Schlett

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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Background The association of longitudinal trajectories of cardiovascular risk factors with cardiovascular magnetic resonance (CMR)-measures of cardiac structure and function in the community is not well known. Therefore we aimed to relate risk factor levels from different examination cycles to CMR-measures of the left ventricle (LV) and right ventricle in a population-based cohort. Methods We assessed conventional cardiovascular disease risk factors in 349 participants (143 women; aged 25–59 years) at three examination cycles (Exam 1 [baseline], at Exam 2 [7-years follow-up] and at Exam 3 [14-years follow-up]) of the KORA S4 cohort and related single-point measurements of individual risk factors and longitudinal trajectories of these risk factors to various CMR-measures obtained at Exam 3. Results High levels of diastolic blood pressure, waist circumference, and LDL-cholesterol at the individual exams were associated with worse cardiac function and structure. Trajectory clusters representing higher levels of the individual risk factors were associated with worse cardiac function and structure compared to low risk trajectory clusters of individual risk factors. Multivariable (combining different risk factors) trajectory clusters were associated with different cardiac parameters in a graded fashion (e.g. decrease of LV stroke volume for middle risk cluster β = − 4.91 ml/m2, 95% CI − 7.89; − 1.94, p < 0.01 and high risk cluster β = − 7.00 ml/m2, 95% CI − 10.73; − 3.28, p < 0.001 compared to the low risk cluster). The multivariable longitudinal trajectory clusters added significantly to explain variation in CMR traits beyond the multivariable risk profile obtained at Exam 3. Conclusions Cardiovascular disease risk factor levels, measured over a time period of 14 years, were associated with CMR-derived measures of cardiac structure and function. Longitudinal multivariable trajectory clusters explained a greater proportion of the inter-individual variation in cardiac traits than multiple risk factor assessed contemporaneous with the CMR exam.

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Association of smoking and physical inactivity with MRI derived changes in cardiac function and structure in cardiovascular healthy subjects

Cited by 12 publications

References 46 publications

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Ethnic differences in right ventricular structure and function in urbanized hypertensive patients in the Gornaya Shoriya region

Functional Capacity, Lipid Profile, and Associated Factors in Older Adults Living in Urban and Rural Areas

Association of antecedent cardiovascular risk factor levels and trajectories with cardiovascular magnetic resonance-derived cardiac function and structure

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