Association of specific haplotype of TNF withα Helicobacter pylori-mediated duodenal ulcer in eastern Indian population

Chakravorty, Meenakshi; Datta, Dipanjana de; Choudhury, Abhijit; Santra, Amal; Roychoudhury, Susanta

doi:10.1007/s12041-008-0048-9

Cited by 14 publications

(11 citation statements)

References 19 publications

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“…However, results in different Table 1 Characteristics of studies included in this meta-analysis. studies have been inconsistent [9,12,[20][21][22][23][24][25]. Moreover, the sample sizes in each of published studies is usullly small and underpowered and thus, unable to provide a definite answer even in the case where a true association exists.…”

Section: Discussionmentioning

confidence: 99%

“…1. A total of eight eligible studies concerning the IL-8 gene À251 T/A polymorphism and PUD risk were included in the final meta-analysis, which contained 1262 PUD cases and 1843 controls [9,12,[20][21][22][23][24][25]. Table 1 listed the detailed characteristics of these studies.…”

Section: Studies Selection Process and Characteristicsmentioning

confidence: 99%

“…Among these eligible studies, six studies were performed in Asians [12,20,21,[23][24][25], and two studies were performed in Europeans [9,22]. Controls were population-based in five studies [9,12,20,21,23], and hospital-based in three studies [22,24,25]. The genotypes in control group for these eligible studies were all consistent with HWE.…”

Section: Studies Selection Process and Characteristicsmentioning

confidence: 99%

“…The genotypes in control group for these eligible studies were all consistent with HWE. Six studies received scores of seven or higher on the NOS and were considered to be of high methodological quality [9,12,20,21,23,24]. The NOS results showed that the average score was 7.13.…”

Section: Studies Selection Process and Characteristicsmentioning

confidence: 99%

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Association between interleukin-8 gene −251 T/A polymorphism and the risk of peptic ulcer disease: A meta-analysis

Yin

Sun³

et al. 2013

Human Immunology

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Section: Discussionmentioning

confidence: 99%

Section: Studies Selection Process and Characteristicsmentioning

confidence: 99%

Section: Studies Selection Process and Characteristicsmentioning

confidence: 99%

Section: Studies Selection Process and Characteristicsmentioning

confidence: 99%

See 2 more Smart Citations

Association between interleukin-8 gene −251 T/A polymorphism and the risk of peptic ulcer disease: A meta-analysis

Yin

Sun³

et al. 2013

Human Immunology

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“…This finding is in agreement with some of previously published results for peptic ulcer patients. No association was stated between PUD incidence and -308G>A TNFA polymorphism in Koreans,13 duodenal ulcers and -308G>A or -1031T>C in eastern Indians,9 or duodenal ulcer disease and -308G>A variation in Chinese Han population 23. On the other hand, Lu et al 7.…”

Section: Discussionmentioning

confidence: 96%

Investigation of -308G>A and -1031T>C Polymorphisms in the TNFA Promoter Region in Polish Peptic Ulcer Patients

Sałagacka¹,

Żebrowska²,

Jeleń³

et al. 2014

Gut Liver

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Background/AimsTumor necrosis factor α (TNF-α) encoded by TNFA is a key mediator in inflammation, a precursor condition for peptic ulceration. Promoter polymorphisms of TNFA that influence its transcriptional activity and TNF-α production are known. TNFA-308G>A (rs1800629) and TNFA-1031T>C (rs1799964), which are responsible for increased TNFA transcription, could influence the risk of peptic ulceration. This study aimed to investigate these polymorphisms and to evaluate their association with peptic ulcer disease and Helicobacter pylori infection in the Polish population.MethodsGastric mucosa specimens obtained from 177 Polish peptic ulcer patients were used to conduct rapid urease tests and to assess the investigated polymorphisms by polymerase chain reaction-restriction fragment length polymorphism. Genotyping data were compared with the results obtained from healthy individuals of Polish origin.ResultsThere were no significant differences in genotype and allele frequency of the investigated polymorphisms between peptic ulcer patients and healthy individuals. No associations between the frequencies of particular genotypes and alleles for both single-nucleotide polymorphisms (SNPs) and the presence of H. pylori infection in peptic ulcer patients and in subgroups of men and women with peptic ulcer disease were found.ConclusionsThe investigated SNPs are not risk factors for either peptic ulcer or H. pylori infection development in the Polish population. The results require verification in a larger cohort.

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Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk

Wang

2013

Tumor Biol.

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Tumor necrosis factor alpha (TNFA) is an important molecule in inflammatory, infectious, and tumoral processes. Inflammation is one of the early phases in the development of gastric cancer (GC). Therefore, several studies have examined the association of polymorphism in TNFA with gastritis and GC risk. A functional polymorphism, -308G>A (rs1800629), which is located in the promoter of TNFA gene, has been suggested to alter the production of TNF-α and influence cancer risk. To date, a number of studies have been carried out to investigate the relationship between the polymorphism and gastritis or GC susceptibility, but the results were conflicting. To investigate this inconsistency, we performed a meta-analysis of 36 studies for TNFA -308G>A polymorphism to evaluate the effect of TNFA on genetic susceptibility for gastritis and GC. An overall random-effects per-allele odds ratio of 1.16 (95 % confidence interval 1.04-1.29, P = 0.008) was found for the polymorphism. Significant results were also observed using dominant or recessive genetic models. In the subgroup analyses by ethnicity, significant results were found in Caucasians, whereas no significant associations were found among East Asians and other ethnic populations. No associations between the polymorphism and gastritis were observed. In addition, our data indicate that TNFA is involved in GC susceptibility and confers its effect primarily in diffuse type of tumors. Besides, -308G>A polymorphism was found to be significantly associated with both cardiac and noncardiac tumors. This meta-analysis demonstrated that the TNFA -308G>A polymorphism is a risk factor for developing GC, but the associations vary in different ethnic populations.

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Association of specific haplotype of TNF withα Helicobacter pylori-mediated duodenal ulcer in eastern Indian population

Cited by 14 publications

References 19 publications

Association between interleukin-8 gene −251 T/A polymorphism and the risk of peptic ulcer disease: A meta-analysis

Association between interleukin-8 gene −251 T/A polymorphism and the risk of peptic ulcer disease: A meta-analysis

Investigation of -308G>A and -1031T>C Polymorphisms in the TNFA Promoter Region in Polish Peptic Ulcer Patients

Quantitative assessment of the influence of tumor necrosis factor alpha polymorphism with gastritis and gastric cancer risk

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