1986
DOI: 10.1002/jcb.240300202
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Association of spectrin with desmin intermediate filaments

Abstract: The association of erythrocyte spectrin with desmin filaments was investigated using two in vitro assays. The ability of spectrin to promote the interaction of desmin filaments with membranes was investigated by electron microscopy of desmin filament-erythrocyte inside-out vesicle preparations. Desmin filaments bound to erythrocyte inside-out vesicles in a spectrin-dependent manner, demonstrating that spectrin is capable of mediating the association of desmin filaments with plasma membranes. A quantitative sed… Show more

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Cited by 66 publications
(27 citation statements)
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“…The undercoat forms the scaffold on the plasmalemma for intermediate filaments, which participate in the spatial arrangement of myofibrils within a muscle cell (LAZARIDES, 1980). Interestingly, spectrin has been shown in vitro to bind to intermediate filaments, suggesting that spectrin may also link intermediate filaments to one another, to actin filaments, and to the plasmalemma (LANGLEY and COHEN, 1986), thus forming a higher hierarchy of cytoskeletal organization.…”
Section: Attachment Of Cytoskeletal Fibrous Componentsmentioning
confidence: 99%
“…The undercoat forms the scaffold on the plasmalemma for intermediate filaments, which participate in the spatial arrangement of myofibrils within a muscle cell (LAZARIDES, 1980). Interestingly, spectrin has been shown in vitro to bind to intermediate filaments, suggesting that spectrin may also link intermediate filaments to one another, to actin filaments, and to the plasmalemma (LANGLEY and COHEN, 1986), thus forming a higher hierarchy of cytoskeletal organization.…”
Section: Attachment Of Cytoskeletal Fibrous Componentsmentioning
confidence: 99%
“…Spectrin, a cytoskeletal protein, is noncovalently associated with the inner side of the red blood cell membrane [2,3] to mediate the association of desmin filaments with plasma membranes [14]. Nonerythrocyte spectrins share erythrocyte spectrin's ability to bind to intermediate filaments and function in nonerythrocyte to promote the interaction of intermediate filaments with actin or/and the plasm membrane [14].…”
Section: Discussionmentioning
confidence: 99%
“…If the material actually represents degraded actin filaments, it might indicate that fodrin binds only actin filaments in the control cell but crosslinks actin and intermediate filaments after the stimulation. In any way, since fodrin can interact with various cytoskeletal filaments and affect their organization (4,5,11), the rapid redistribution of fodrin (8) is possibly a causative factor rather than a result of changes in other components.…”
Section: Discussionmentioning
confidence: 99%