Association of SRB1 and PON1 gene polymorphisms with type 2 diabetes mellitus: a case control study

Wamique, Mohd; Ali, Wahid; Himanshu, D

doi:10.1007/s13410-019-00787-2

Cited by 8 publications

(15 citation statements)

References 27 publications

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“…Mounting evidence suggests a scenario where PON1 and T2D are reciprocally related [ 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Various factors contribute to the development of T2D, such as genetic, lifestyle, and environment [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ]. The genetic predisposition of having low PON1 expression and activity has been ascribed as one of these influential factors by several authors [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…Nonetheless, the evidence of differential expression of PON1 in the context of T2D is still undisclosed. Indeed, the only known information about PON1 expression in T2D is related to its genetic polymorphisms, which have been suggested to be responsible for variations in serum PON1 activity of T2D patients [ 27 ]. Consistently, the majority of population-based studies on the PON1 phenotype, found that low enzymatic activity is associated with T2D and related clinical complications, and this, in turn, could be due to the increased levels of pro-atherogenic oxidized LDL and HDL of these patients [ 28 , 29 , 30 , 31 ].…”

Section: Introductionmentioning

confidence: 99%

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Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

et al. 2020

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Type-2 diabetes (T2D) and its cardiovascular complications are related to sex. Increasing evidence suggests that paraoxonase 1 (PON1) activity, an antioxidant enzyme bound to high-density lipoproteins (HDL), is implicated in the onset and clinical progression of T2D. Since we previously showed that PON1 is a sexual dimorphic protein, we now investigated whether sex might impact the relationship between PON1 and this chronic disease. To address this aim, we assessed PON1 activity in the sera of 778 patients, including controls (women, n = 383; men, n = 198) and diabetics (women, n = 79; men = 118). PON1 activity decreased in both women and men with T2D compared with controls (p < 0.05 and p > 0.001, respectively), but the change was 50% larger in the female cohort. In line with this result, the enzyme activity was associated with serum glucose level only in women (r = −0.160, p = 0.002). Notably, only within this gender category, lower PON1 activity was independently associated with increased odds of being diabetic (odds ratio (95% Confidence interval: 2.162 (1.075–5.678)). In conclusion, our study suggests that PON1-deficiency in T2D is a gender-specific phenomenon, with women being more affected than men. This could contribute to the partial loss of female cardiovascular advantage associated with T2D.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

et al. 2020

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“…Wamique et al reported that diabetic patients with the RR genotype have higher LDL-C and lower HDL-C levels vs. non-carriers ( 36 ). Similarly, in Hassan et al’s study, RR genotype carriers had significantly lower HDL-C levels and higher TC, LDL-C, and TG levels than the QQ carriers ( 33 ). Interestingly, in another study, the R vs. Q allele was associated with increased HDL-C in white adults, whereas the opposite was true in blacks.…”

Section: Discussionmentioning

confidence: 74%

The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD

Darand

Salehi‐Abargouei

Mehrjardi

et al. 2023

Front. Cardiovasc. Med.

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IntroductionThe present study aimed to investigate the association of the paraoxonase 1 (PON1) Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD.MethodsThis cross-sectional study was conducted on 428 patients undergoing angiography. The data related to demographic information and physical activity were collected by valid and reliable questionnaires. The PON-1 genotypes were detected by the polymerase chain reaction-restriction fragment length polymorphism (RFLP-PCR) technique. The Gensini and SYNTAX score, anthropometric measurements, and biochemical and clinical parameters were measured by standard protocols.Results and discussionFindings indicated that the odds of obesity was significantly higher in people with the RR genotype compared to the QQ genotype carriers (OR: 2.95 CI: 1.25–6.93, P = 0.014) and also odds of low high-density lipoprotein cholesterol (HDL-C) was marginally higher (OR: 2.31 CI: 0.97–5.49, P = 0.056). There was no significant association between other CAD risk factors with PON1 Q192R polymorphism (P > 0.05). Further analysis showed a significant interaction between sex and 192QR (P = 0.019) and 192 RR (P = 0.007) genotypes on body mass index (BMI). More specifically, the risk of obesity in men carrying the RR genotype was 3.38 times (OR: 3.38 CI: 1.08–10.58, P = 0.036). Also, a significant joint effect of the RR genotype and sex on HDL-C was seen (P = 0.003). The stratification based on sex showed that the risk of low HDL-C is significantly higher in women carrying the RR genotype (OR: 6.18 CI: 1.21–31.46, P = 0.028). A marginal sex-genotype interaction was also found in the risk of elevated alanine aminotransferase (ALT) (P = 0.057). In summary, the findings showed that the risk of obesity and low HDL-C was higher in people carrying the RR genotype. On the other hand, a Q192R polymorphism-sex interaction was observed on the risk of obesity, elevated ALT, and low HDL-C.

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“…Numerous studies previously showed the association of the SCARB1 gene with T2DM although SRB1 is not an uncommonly studied gene in T2DM, there is a limited understanding of whether these variant is associated with insulin resistance [10]. The data remains controversial due to variations in association with insulin resistance on different ethnic populations.…”

Section: Discussionmentioning

confidence: 99%

Scavenger Receptor Class B Type 1 Gene Polymorphism as a Possible Genetic Risk Factor for Insulin resistance

Himanshu

Wamique

Tamrakar

et al. 2022

Preprint

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The association between SCARB1 rs74830677 (c.1127 C > T, [P.pro 367 leu] P367L) gene polymorphisms and insulin resistance (IR) has been not been analysed and studied. The clinical relevance of these findings remained uncertain and brings into question the importance of SCARB1 in human physiology. So, we investigated the hypothesis the SCARB1 SNPs in association with the risk of developing insulin resistance. A total of 600 individuals, including 300 T2DM and 300 healthy individuals, were enrolled in the study. Blood samples were collected from each T2DM and healthy individual. CT method for the relative quantitation were used for gene expression level in T2DM and healthy controls. Also, restriction fragment length polymorphism analysis was achieved to detect the incidence of genetic polymorphisms. HOMA resistance index and QUICKI were calculated from fasting plasma glucose and insulin values. In the present study, there was strong association observed between T2DM and SCARB1 rs74830677 gene polymorphism (OR = 1.7, 95% CI 1.18–2.71, P = 0.07). Further, T allele were associated with increase serum insulin and HOMA-IR. Our genotyping data showed that SCARB1 rs7480677 variant is significantly higher in subjects with increased HOMA-IR. Thus, we conclude that SCARB1 polymorphisms may play a crucial role in pathogenesis and susceptibility of insulin resistance thus leads to the development of type 2 diabetes mellitus.

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Association of SRB1 and PON1 gene polymorphisms with type 2 diabetes mellitus: a case control study

Cited by 8 publications

References 27 publications

Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

Sex Difference Impacts on the Relationship between Paraoxonase-1 (PON1) and Type 2 Diabetes

The association of the paraoxonase 1 Q192R polymorphism with coronary artery disease (CAD) and cardiometabolic risk factors in Iranian patients suspected of CAD

Scavenger Receptor Class B Type 1 Gene Polymorphism as a Possible Genetic Risk Factor for Insulin resistance

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