Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis

Liu, Qi-Fei; Li, Yang; Zhao, Qihong; Wang, Zheng-Yu; Hu, Shuang; Yang, Chaoqun; Ye, Kui; Li, Li

doi:10.1016/j.clinre.2015.04.002

Cited by 17 publications

(15 citation statements)

References 33 publications

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“…STAT4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages, and plays a significant role in the signalling pathway of several important cytokines [5, 6]. Furthermore, dysregulation of STAT4 has been found in some autoimmune diseases [7–9]. …”

Section: Introductionmentioning

confidence: 99%

STAT4 gene polymorphism in patients after renal allograft transplantation

Dąbrowska-Żamojcin

Dziedziejko

Safranow

et al. 2016

cejoi

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IntroductionSTAT4 (signal transducer and activator of transcription 4) is involved in the regulation of innate and adaptive immune responses. Some studies have suggested that STAT4 may be involved in the immune response after graft transplantation. Several polymorphisms in the STAT4 gene have been identified. The most commonly studied polymorphism in the STAT4 gene is rs7574865. In our study, we examined whether this polymorphism is associated with the early and late functions of renal allografts.Material and methodsA total of 270 recipients of first renal transplants were included in the study. Single nucleotide polymorphisms (SNPs) within the STAT4 gene were genotyped using TaqMan genotyping assays.ResultsThere were no statistically significant associations between the STAT4 gene rs7574865 polymorphism and delayed graft function, acute rejection, chronic allograft dysfunction, post-transplant diabetes mellitus, or creatinine serum concentrations after transplantation.ConclusionsOur results suggest a lack of association between the STAT4 rs7574865 SNP and kidney allograft function in the Polish population.

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Section: Introductionmentioning

confidence: 99%

STAT4 gene polymorphism in patients after renal allograft transplantation

Dąbrowska-Żamojcin

Dziedziejko

Safranow

et al. 2016

cejoi

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“…Several SNPs in the gene have been significantly association with Behcet's Disease [119], diabetes risk [107], hepatitis B virus-related hepatocellular carcinoma [107,111,120,121], inflammatory bowel disease [122], juvenile idiopathic arthritis [123], primary biliary cirrhosis and Crohn's disease [124], severe renal insufficiency in lupus nephritis [109], systemic lupus erythematosus [106] and ulcerative colitis [125]. Some STAT4 SNPs were found to create alterations in punitive TFBS and these punitive changes were examined with respect to these disease or conditions [25].…”

Section: Signal Transducer and Activator Of Transcription 4 (Stat4)mentioning

confidence: 99%

“…The rs7574865 STAT4 SNP (G/T) has been found to be significantly associated with diabetes [112], hepatitis B virus-related hepatocellular carcinoma [107,111,120,121], inflammatory bowel disease [122], juvenile idiopathic arthritis [123], primary biliary cirrhosis and Crohn's disease [124], severe renal insufficiency in lupus nephritis [109], systemic lupus erythematosus [106] and ulcerative colitis [125]. The minor T-allele for the SNP creates a unique punitive TFBS not found with the common G-allele for the nuclear receptor subfamily 1, group H, member 3: retinoid X receptor, alpha (NR1HE:RXRα TF which is a key regulator of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation [25].…”

Section: Signal Transducer and Activator Of Transcription 4 (Stat4)mentioning

confidence: 99%

SNPs, transcriptional factor binding sites and disease

Buroker¹

2017

Biomed Genet Genomics

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“…The coding region consists of 22 exons with a large 70 kb intron between exons 2 and 3. Several SNPs in the gene have been significantly association with Behcet's Disease [18], diabetes risk [11], hepatitis B virus-related hepatocellular carcinoma [6,10,19,20], inflammatory bowel disease [21], juvenile idiopathic arthritis [22], primary biliary cirrhosis and Crohn's disease [23], severe renal insufficiency in lupus nephritis [8], systemic lupus erythematosus [5] and ulcerative colitis [24] ( Table 1).…”

Section: Introductionmentioning

confidence: 99%

“…The rs7574865 STAT4 SNP has been found to be significantly associated with diabetes [11], hepatitis B virus-related hepatocellular carcinoma [6,10,19,20], inflammatory bowel disease [21], juvenile idiopathic arthritis [22], primary biliary cirrhosis and Crohn's disease [23], severe renal insufficiency in lupus nephritis [8], systemic lupus erythematosus [5] and ulcerative colitis [24]. The rs11889341 STAT4 SNP has been found to be significantly associated with diabetes [11], hepatitis B virus (HBV) infection, HBV-related cirrgisus and hepatocellular carcinoma [23], severe renal insufficiency in lupus nephritis [8], and systemic lupus erythematosus [5].…”

Section: Introductionmentioning

confidence: 99%

Computational STAT4 rSNP Analysis, Transcriptional Factor Binding Sites And Disease

Buroker

2016

JBD

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Purpose -Signal Transducer and Activator of Transcription 4 (STAT4) is important for signaling by interleukins and type 1 interferons and has been found to have several simple nucleotide polymorphisms (SNPs) associated with human disease. STAT4 SNPs were computationally examined with respect to changes in potential transcriptional factor binding sites (TFBS) and these changes were discussed in relation to human disease. Methods -The JASPAR CORE and ConSite databases were instrumental in identifying the TFBS. TheVector NTI Advance 11.5 computer program was employed in locating all the TFBS in the STAT4 gene from 4 kb upstream of the transcriptional start site to 8.3 kb past the 3'UTR. The JASPAR CORE database was also involved in computing each nucleotide occurrence (%) within the TFBS.Results -The STAT4 SNPs in the 70 kb intron between exon 2 and 3 are in linkage disequilibrium and have previously been found to be significantly associated with several vasculitis diseases as well as diabetes. The SNP alleles were found to alter the DNA landscape for potential transcriptional factors (TFs) to attach resulting in changes in TFBS and thereby, alter which transcriptional factors potentially regulate the STAT4 gene. These STAT4 SNPs should be considered as regulatory (r) SNPs.Conclusion -The alleles of each rSNP were found to generate unique TFBS resulting in potential changes in TF STAT4 regulation. These regulatory changes were discussed with respect to changes in human health that result in disease.

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Association of STAT4 rs7574865 polymorphism with susceptibility to inflammatory bowel disease: A systematic review and meta-analysis

Cited by 17 publications

References 33 publications

STAT4 gene polymorphism in patients after renal allograft transplantation

STAT4 gene polymorphism in patients after renal allograft transplantation

SNPs, transcriptional factor binding sites and disease

Computational STAT4 rSNP Analysis, Transcriptional Factor Binding Sites And Disease

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