Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures

Martin, Donald C.; Schmidt, Robert A.; Mortensen, Eric M.; Mansi, Ishak A.

doi:10.1177/1060028015622649

Cited by 7 publications

(13 citation statements)

References 31 publications

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“…The study methods have been previously published . Briefly, this was a retrospective cohort study using patients enrolled in the San Antonio Military Healthcare System from October 1, 2003, to March 1, 2012, after approval from institutional review boards of relevant institutions.…”

Section: Methodsmentioning

confidence: 99%

“…Statin therapy was not limited to any particular statin or dose. Exclusion criteria included those who received statins for <90 days during the study period or were initiated on statins after the baseline period …”

Section: Methodsmentioning

confidence: 99%

“…Diagnosis is based on ICD‐9‐CM codes as identified in Deyo method for applying the Charlson comorbidity score …”

Section: Methodsmentioning

confidence: 99%

“…The study methods have been previously published. [14][15][16] Briefly, this was a retrospective cohort study using patients enrolled in the San Antonio Military Healthcare System from October 1, 2003 The statin group was defined as statin-naive patients who filled a statin prescription for ࣙ90 days starting in the 2005 fiscal year. The nonuser group was defined as patients who were not on statin therapy during the baseline or follow-up periods.…”

Section: Methodsmentioning

confidence: 99%

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Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Pearlman

Covin

Schmidt

et al. 2017

The Journal of Clinical Pharma

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Several studies have reported constipation, abdominal pain, or diarrhea as common adverse events for statins. Statins are among the most commonly prescribed medications, and the impact on the prevalence of these conditions was rarely studied as main outcomes. The aim of this study is to determine if statin therapy is associated with constipation, abdominal pain, diarrhea, or colitis. This was a retrospective cohort study using a regional military health care data from October 1, 2003, to March 1, 2012. A propensity score-matched cohort of statin users and nonusers was created based on 82 variables. The primary analysis evaluated the odds ratios of the following diagnoses: constipation, ≥3 encounters for constipation; abdominal pain, ≥3 encounters for abdominal pain; diarrhea, ≥3 encounters for diarrhea; colitis, ≥3 encounters for colitis; and endoscopy of the lower gastrointestinal tract, ≥3 endoscopies of the lower gastrointestinal tract. After propensity score matching of 6342 statin users and 6342 nonusers, there was no statistically significant difference in constipation (OR, 0.96; 95%CI, 0.87-1.05; P = .33), abdominal pain (OR, 0.95; 95%CI, 0.88-1.02; P = .15), or colitis (OR, 1.02; 95%CI, 0.91-1.14; P = .73). However, there was an association between statin therapy and endoscopy of the lower gastrointestinal tract (OR, 1.14; 95%CI, 1.04-1.26; P = .002) and decreased odds of diarrhea (OR, 0.88; 95%CI, 0.80-0.97; P = .01). In this retrospective cohort study, an association between statin therapy and increased likelihood of being diagnosed with lower gastrointestinal conditions could not be demonstrated, contrary to some statins package inserts.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

“…Diagnosis is based on ICD‐9‐CM codes as identified in Deyo method for applying the Charlson comorbidity score …”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Pearlman

Covin

Schmidt

et al. 2017

The Journal of Clinical Pharma

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“…However, it has been reported that statin therapy, which is taken as a class of most effective drugs for lipid-lower therapy, is not significantly associated with either an increased or decreased risk of gallstone. 35 Therefore, statins may not be effective to reverse hypercholesterolemia-induced changes in gallstone formation. In the present study, we found that hypercholesterolemia reduced Tyr-phosphorylation of BK Ca a-subunit, which may play a key role in downregulated BK Ca channel activity and SO motility.…”

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confidence: 99%

Expression and alteration of BK_Ca channels in the sphincter of Oddi's from rabbits with hypercholesterolemia

et al. 2017

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This study aimed to investigate the expression and function of BK Ca channels in the Sphincter of Oddi (SO) in a rabbit model of hypercholesterolemia (HC). New Zealand white rabbits were randomly divided into 2 groups: the control group was fed standard chow (n D 18) whereas the high-cholesterol group was fed cholesterol-enriched chow containing 1.5% cholesterol (n D 18). The serum cholesterol level was significantly greater in the HC groups than in the control group, but there was no significant difference in body weight between the control and HC groups. Although the total protein expression of BK Ca a-and b 1 -subunit was not significantly different between the control and HC groups, the Tyr-phosphorylation of BK Ca a-subunit was significantly decreased in the HC group than in the control group. In addition, hypercholesterolemia significantly increased Acetylcholine (ACh)-induced contraction of the SO rings. Pretreatment with 30 mM NS1619, a BK Ca channel agonist, significantly reduced ACh-induced contraction of the SO rings in HC rabbits. Moreover, pretreatment with 100 mM Na 3 OV 4 , a protein tyrosine phosphatase inhibitor, significantly reduced ACh-induced contraction of the SO rings in HC rabbits, whereas it significantly increased upon pretreating with 10 mM Genistein, a tyrosine kinase inhibitor. Whole-cell patch clamp recordings showed that BK Ca current density was significantly lower in SOSMCs from HC group than that from control group. Our findings suggest that hypercholesterolemia-induced downregulation of BK Ca channel, and Tyr-phosphorylation of BK Ca a-subunit may contribute to the hyperresponsiveness of the SO ring in HC rabbits.

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The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases

Sou,

Hsu,

Chiu

et al. 2024

Journal of the Formosan Medical Association

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Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures

Abstract: Statin use was not significantly associated with either an increased or decreased risk of cholelithiasis or gallbladder disease.

Cited by 7 publications

References 31 publications

Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Expression and alteration of BK_Ca channels in the sphincter of Oddi's from rabbits with hypercholesterolemia

The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases

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Association of Statin Therapy and Risks of Cholelithiasis, Biliary Tract Diseases, and Gallbladder Procedures

Abstract: Statin use was not significantly associated with either an increased or decreased risk of cholelithiasis or gallbladder disease.

Cited by 7 publications

References 31 publications

Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Statins and Lower Gastrointestinal Conditions: A Retrospective Cohort Study

Expression and alteration of BKCa channels in the sphincter of Oddi's from rabbits with hypercholesterolemia

The association between trajectory of serum cholesterol, statin dosage, and the risk of recurrent biliary stone diseases

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Product

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Expression and alteration of BK_Ca channels in the sphincter of Oddi's from rabbits with hypercholesterolemia