Association of suboptimal 25-hydroxyvitamin D levels with knee osteoarthritis incidence in post-menopausal Egyptian women

Abstract

The main aim of this study was to assess the vitamin D status of newly diagnosed knee osteoarthritis (OA) patients. Thirty-six post-menopausal Egyptian females of mean age 54.7 years with knee OA were recruited alongside ten healthy males of mean age 25.8 years. The body mass index of all knee OA patients was calculated, and full patient history was gathered to screen for vitamin D status altering conditions or medication. Total 25-hydroxyvitamin D [25(OH)D] was assessed using HPLC which permitted an individualized assessment of both forms of the vitamin's metabolite, 25(OH)D2 and 25(OH)D3. Results showed that mean 25(OH)D ± SEM concentrations were 25.0 ± 1.6 ng/mL and 35.4 ± 2.1 ng/mL for female patients and healthy male participants, respectively. Student's t test statistical comparison yielded a significant result (P = 0.001) when comparing healthy and osteoarthritic participants, and insignificant results when comparing patients of different BMI class, and the different forms of the vitamin's metabolite (P = 0.184 and 0.335, respectively). The 95 % confidence interval associated with knee OA incidence is 21.9-28.1 ng/mL, which is in the vitamin D insufficiency zone. In Conclusion, suboptimal 25(OH)D levels are associated with knee OA incidence in post-menopausal Egyptian females which further fortifies accumulating evidence.

The Effects of Vitamin D Supplementation in Patients with Knee Osteoarthritis: Uncontrolled Open Label Clinical Trial

“…Recently, vitamin D deficiency was pointed out as a risk factor for pain in OA in black Americans [17]. In a case-control study, post-menopausal Egyptian women with OA found to have significantly lower vitamin D levels compared to those without OA [18]. Furthermore, a study conducted in Iran showed significant improvement in WOMAC scores and visual analogue scale (VAS), as well as quadriceps muscle strength, in patients with knee OA after serum vitamin D level correction [19].…”

Can Vitamin D Slow Progression of Osteoarthritis?

“…The exact involvement of hormones as estrogen and menopausal stage on OA and vitamin D needs to be established. An Egyptian study on newly diagnosed post-menopausal women showed lower 25(OH)D 3 in their serum and was associated with knee OA when compared to healthy males [19]. The patients choosen in our study were only those who had only osteoarthritis without any co-morbid conditions.…”

Repair of the comminuted fracture of the lower patellar pole

“…Suboptimal vitamin D level is associated with incidence of knee osteoarthritis in postmenopausal females. [17] Moreover, low vitamin D level influences structural progression of osteoarthritis, in addition to association with muscle weakness and increased pain. [18] Present study is limited by lack of control group.…”