Association of telomere length with diabetes mellitus and idiopathic dilated cardiomyopathy in a South Indian population: A pilot study

Rai, Shivam; Badarinath, A. R. S.; George, Alex; Sitaraman, Sneha; Bronson, Stephen Charles; Anandt, Sudha; Babu, K. Thirumal; Moses, Anand; Saraswathy, Radha; Hande, M. Prakash

doi:10.1016/j.mrgentox.2021.503439

Cited by 5 publications

(1 citation statement)

References 49 publications

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“…Signals that cause cell growth, differentiation, death, and other processes activate transcription factors of the NFKB family 29 . Ageing and various age-related illnesses, such as cancer, coronary artery disease, heart failure, and diabetes, have been linked to telomere shortening 30 . In the pathophysiology of T2DM, apoptosis has crucial functions and several factors contribute to the aetiology of T2DM, including insulin resistance caused by obesity, poor insulin production, and loss of β-cell mass due to β-cell apoptosis 31 .…”

Section: Discussionmentioning

confidence: 99%

Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Dirican

Kaya

2023

Cukurova Medical Journal

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Purpose: Type 2 diabetes mellitus (T2DM) is a heterogeneous, chronic, and metabolic disease that affects a significant proportion of the global population. This study aimed to evaluate the effect of NFKB1 -94 ATTG ins/del polymorphisms on the expression of apoptosis genes and telomere length (TL) in patients with T2DM compared with healthy individuals. Materials and Methods: Sixty-nine T2DM patients and sixty healthy people were enrolled in the study. DNA and RNA were isolated from the blood samples. NFKB1 genotypes were identified by Sanger sequencing. For TL analyses and to investigate the expression of the caspase-3, caspase-9, bax, and bcl2 genes, RT-PCR was utilized. Results: There was a significant difference between the NFKB1 -94 ins/del genotype patients and the control group (OR:0.4792 (0.2345-1.011)). However, the distribution of other genotype/alleles (ins/ins and del/del) showed no difference between T2DM and control groups. The allelic frequency of NFKB1 -94 ins/del was 0.455/0.235 for the T2DM group and 0.435/0.165 for the control group. An increase in the mRNA expression of caspase-3, caspase-9 and Bax genes was observed in the T2DM group compared with the healthy group, while a decrease in the Bcl2 gene was found in the T2DM group. TL in T2DM patients was shorter than in healthy individuals. Conclusion: NFKB1 -94 ins/del polymorphisms show significant differences in T2DM patients. We observed that apoptosis was activated and TL was shortened in patients with T2DM. However, no relationship between NFKB1 polymorphisms and apoptosis and TL could not be determined.

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Section: Discussionmentioning

confidence: 99%

Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Dirican

Kaya

2023

Cukurova Medical Journal

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Telomere length as a biomarker for cerebrovascular diseases: current evidence

da Cunha Agostini,

da Silva

2024

Mol Biol Rep

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Effect of Exercise on Oxidative Stress and Telomere Length in Type 2 Diabetes

Gupta

KAUSHIK

Amaravadi

2023

Crit Rev Phys Rehabil Med

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Diabetes mellitus is the ninth leading cause of death across the globe. Long-term hyperglycemia is associated with hyperlipidemia and oxidative stress. Increased oxidative stress reduces the length of the telomere, which is a biological indicator of aging in humans. Exercise regulates the equilibrium between reactive species generation and antioxidant processes, lowering oxidative stress and risk of chronic disease. Exercise has also been associated with molecular and cellular factors, such as telomere length, which are linked to reducing the risk of disease and improving longevity. Therefore, this review was conducted to appraise regular exercise intervention efficiency in minimizing the DNA damage and preserving telomere length along with genomic stability in various chronic conditions.

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Association of telomere length with diabetes mellitus and idiopathic dilated cardiomyopathy in a South Indian population: A pilot study

Cited by 5 publications

References 49 publications

Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Investigation of the relationship between NFKB1 polymorphisms and telomere length and apoptosis in patients with type-2 diabetes

Telomere length as a biomarker for cerebrovascular diseases: current evidence

Effect of Exercise on Oxidative Stress and Telomere Length in Type 2 Diabetes

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