Association of TGFB1 gene polymorphisms with cervical cancer in Bangladeshi women: A case-control study

Abstract

OBJECTIVES: Genetic susceptibility to cervical cancer in relation to transforming growth factor beta 1 (TGFB1) gene polymorphisms has not been investigated extensively among the women in Bangladesh. So, the aim of this study was to find out the correlation of the polymorphisms of TGFB1 C509T (rs1800469) and T869C (rs1800470) with the risk of cervical cancer among the Bangladeshi women. STUDY DESIGN: 134 cervical cancer patients and 102 age-sex matched healthy controls were included from two institutions in Bangladesh. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used for genotyping two TGFB1 single nucleotide polymorphisms C509T (rs1800469) and T869C (rs1800470) in patients and controls. RESULTS: No significant correlation was found between polymorphisms C509T (rs1800469) and T869C (rs1800470) of TGFB1 gene with cervical cancer in Bangladeshi women. In case of the cervical cancer patients who had first degree relatives with cancer were prone to carry the polymorphic version of the TGFB1 gene polymorphism at C509T (OR = 5.597, 95% CI = 1.224–25.597, p < 0.05) but may not result in the increase of developing cervical cancer. CONCLUSION: In summary, two polymorphisms C509T and T869C of TGFB1 gene may not be associated with cervical cancer risk in Bangladeshi women.

TGFβ1, SMAD2, CTNNβ1, and Wnt3a gene mutational status and serum concentrations in individuals with non-small cell lung cancer

“…In contrast, an additional investigation conducted by Chen et al concluded that the TGFβ1 (rs1800470) and (rs1800469) polymorphisms were not associated with lung cancer development and revealed the (rs1800469) poly-morphism diminishes the danger of lung cancer growth in patients with NSCLC (39,44). However, in our study, (rs1800470), (rs1800469) and (rs1800470) polymorphisms have been related to the high expression of TGFβ1 in adenocarcinoma for NSCLC in stages III and IV.…”

Identification of key biomarkers and related immune cell infiltration in cervical cancer tissue based on bioinformatics analysis

“…The high mortality of CC is largely due to the untimely diagnosis, so it is important to find specific biomarkers for early diagnosis to improve the prognosis of CC patients. Several studies have shown that the genes with partial disorder in CC patients can be used as biomarkers for their diagnosis 22 , 23 . Immunotherapy is an anti-cancer therapy that has attracted much recent attention.…”