Association of the Apolipoprotein E ε4 Allele with Late-Onset Depression

Rigaud, Anne‐Sophie; Traykov, Latchezar; Caputo, Ludovica; Coste, Joël; Latour, F.; Couderc, Rémy; Moulin, F.; Boller, François; Forette, Françoise

doi:10.1159/000054801

Cited by 49 publications

(42 citation statements)

References 34 publications

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“…Such differences could be contributed much to the ethnicity of populations and genders, since depression might be more associated with ApoE-"4 in women than in men 20 and the frequency of ApoE-"4 in Western populations is also higher compared to Asian populations. 21,22 Nonetheless, those with ApoE-"4/"4 might experience depression with a relative paucity of depressive symptoms compared to those without this allele, 23 which was also shown in our study (6.9% in Group I and 8.0 in Group III). However, the biological mechanisms revealing the modulating effect of ApoE-"4 on depression are not fully explicit.…”

Section: Discussionsupporting

confidence: 85%

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Zhang

Shen

et al. 2015

Renal Failure

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Objective: To explore the relation between the frequencies of apolipoprotein E (ApoE) alleles and the occurrence of depression in patients undergoing hemodialysis in a Chinese population. Methods: We examined the ApoE alleles in a sample of 288 subjects: 72 patients with depression under hemodialysis, 74 patients without depression under hemodialysis, 75 patients with depression under nondialytic treatment and 67 patients without depression under nondialytic treatment. The depression state was assessed using the Center for Epidemiological Studies Depression (CES-D) scale. Associations between the occurrence of depression and the frequencies of ApoE alleles were examined using multinomial logistic regression models with adjustment of relevant covariates. Information about sociodemographics, clinical data, vascular risk factors and cognitive function was also collected and evaluated. Results: The frequencies of ApoE-"2 were significantly different between depressed and non-depressed patients irrespective of dialysis (p50.05), but no significant difference was found in the frequencies of ApoE-"4 (p40.05). Serum ApoE levels were significantly different between depressed and nondepressed patients in the whole sample (p50.05). Multinomial logistic regression models showed significant association between the frequency of ApoE-"2 and the occurrence of depression in the Chinese population after control of relevant covariates, including age, sex, educational level, history of smoking and drinking, vascular risk factors and cognitive function. Conclusions: No association between the frequency of ApoE-"4 and the occurrence of depression was found in patients undergoing hemodialysis. Further research is needed to find out if ApoE-"2 acts as a protective factor in Chinese dialysis population since it might decrease the prevalence of depression and delay the onset age.

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Section: Discussionsupporting

confidence: 85%

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Zhang

Shen

et al. 2015

Renal Failure

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“…With our finding that patients carrying the APOE4 allele have increased suicidality, it would be of interest to test whether the association between lifetime suicidal attempt and coronary artery disease is due to a genetic effect of APOE. Similar to many other studies [7][8][9][10][11][12][13] , our results do not support previously noted associations between APOE status and geriatric depression [5,6] , suggesting that the APOE polymorphism investigated in this study does not constitute a susceptibility factor for geriatric depression. Further, our study found no association between APOE status and age of onset of geriatric depression.…”

Section: Discussionsupporting

confidence: 65%

“…This finding is partially supported by another study that compared early-and lateonset depression with a control group. In the late-onset group, but not in the early-onset sample, the APOE4 frequency was significantly higher than in the controls [6] .…”

Section: Introductioncontrasting

confidence: 56%

Association of APOE Genetic Polymorphism with Cognitive Function and Suicide History in Geriatric Depression

Hwang

Yang

Chen

et al. 2006

Dement Geriatr Cogn Disord

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Apolipoprotein E (APOE) has been associated with a variety of late-life neuropsychiatric disorders, including geriatric depression. This study determined whether APOE genotypes affect vulnerability to geriatric depression. We also tested the effect of the presence of the APOE Ε4 (APOE4) allele on age of onset, suicide attempt history and cognitive function in geriatric depressed patients. We genotyped APOE in 111 elderly inpatients diagnosed as having major depression and 144 normal controls. The depressed patients were evaluated at baseline using the Hamilton Rating Scale for Depression and the Mini-Mental State Examination (MMSE) after admission. Age of onset of depression and suicide attempt history in the depressed group were evaluated by interview and medical record. We found no association between APOE genotypes and geriatric depression (p = 0.342) or APOE4 status and age of onset of depression (p = 0.281). However, compared with depressed subjects lacking the APOE Ε4 allele, depressed subjects who were also APOE4 carriers showed significantly lower MMSE scores (p = 0.021) and an increased suicide attempt history (p = 0.012). The APOE genotype may contribute to cognitive performance and suicidality in geriatric depression, rather than being a specific risk factor for the disorder.

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“…Although it is now clear that the ε4 allele of the apolipoprotein E gene (APOE-ε4), a plasma protein involved in the transport of cholesterol and lipids throughout the body, is an important risk factor for AD Corder et al, 1993;Farrer et al,1997;Aggarwal et al, 2005), inconsistencies exist across studies investigating whether this susceptibility gene modifies the risk for depression in AD. Early studies examining this relationship showed a positive association between depression and the APOE ε4 allele in patients with AD (Murphy, Taylor, Tinklenberg, & Yesavage, 1997;Ramachandran et al, 1996), and other investigators have demonstrated combined risks of developing AD among those with late-onset depression and APOE ε4 genotypes in nondemented geriatric populations (Krishnan et al, 1996;Steffens et al, 1997;Wilson et al, 2002;Rigaud et al, 2001). A recent study suggested that depression and APOE ε4 genotype may be higher in women with AD but not in men (Muller-Thomsen et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study

Delano‐Wood

Houston

Emond

et al. 2007

Int J Geriat Psychiatry

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The association between the epsilon-4 type allele of apolipoprotein E (APOE ε4) and depression was investigated in 323 AD patients. Patients were divided into two groups based on the presence (n=61) or absence (n=262) of depression as assessed by the DSM-based Diagnostic Interview Schedule. Both subgroups were demographically comparable with regard to age, education, gender, and severity of cognitive impairment. Analysis of the frequency of APOE ε4 alleles between the groups revealed a significantly higher prevalence rate of the APOE ε4 genotype in the depressed group (72% of depressed AD patients carried at least one copy of the ε4 allele) compared to the non-depressed AD patients (58%). This effect was primarily accounted for by women. Specifically, an interaction was revealed wherein women who possessed the APOE ε4 allele were almost 4 times more likely to be depressed in comparison to those who did not carry the allele, and APOE ε4 status did not predict depression among men in our sample. These results are consistent with recent suggestions that the APOE ε4 genotype may be over-represented among women with AD and depression and highlight a need for additional research investigating the links between APOE genotype, mood, and gender.Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by progressive neuropsychological, functional, and behavioral decline. Currently, there are 4.5 million people with AD in the United States and the prevalence is expected to increase to 11 -16 million by 2050 (Alzheimer's Association, 2004. Psychiatric disturbance is frequently seen in AD and, although prevalence rates vary considerably across studies (e.g., 1 -90%), average rates of coexisting AD and depression appear to hover around 20 to 40% (Wragg & Jeste, 1989;Cummings, Ross, Absher, Gornbein & Hadjiaghai, 1995;Tractenberg, Weiner, Patterson, Teri, & Thal, 2003;Green et al., 2003). Lyketsos and Olin (2002) reported that behavioral disturbances among AD patients are 3 to 4 times higher than that seen in normal aging.Adverse consequences of depression in patients with AD are numerous, including greater impairment in activities of daily living (Lyketsos et al., 1997b), poorer quality of life (GonzalesSalvador et al., 2000), earlier institutionalization (Magni, Bionetti, Bianchetti, & Trabucchi, 1996), greater caregiver depression and level of burden (Gonzales-Salvador et al., 1999) (Stern et al., 1997), and higher mortality rates (Ganguli, Hodge, & Mulsant, 2002;Hoch et al., 1993). In addition, neuropsychiatric symptoms significantly increase direct annual costs of care among AD patients, even after adjusting for the severity of cognitive impairment and other medical comorbidities (Murman et al, 2002).Neuropathologically, depressive symptoms appear to be associated with a selective loss of noradrenergic and serotonergic nuclei in the brainstem (Zubenko, 2000) and these losses may be related to genetic risk factors for AD (Craig, Hart, McIlroy, & Passmore, 2005). Although it is now clear ...

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Association of the Apolipoprotein E ε4 Allele with Late-Onset Depression

Cited by 49 publications

References 34 publications

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Frequencies of apolipoprotein E alleles in depressed patients undergoing hemodialysis – a case-control study

Association of APOE Genetic Polymorphism with Cognitive Function and Suicide History in Geriatric Depression

APOE genotype predicts depression in women with Alzheimer's disease: a retrospective study

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