Association of APOE Genetic Polymorphism with Cognitive Function and Suicide History in Geriatric Depression

Hwang, Jen Ping; Yang, Chen Hong; Chen, Hong; Lirng, Jiing Feng; Yang, Ya Min; Tsai, Shih‐Jen

doi:10.1159/000095599

Cited by 38 publications

(20 citation statements)

References 59 publications

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“…Despite the plausibility of the association and one report of increased APOE4 frequency in older depressed patients (Krishnan et al, 1996), most subsequent studies have found APOE status to be unrelated to depression in older adults (e.g., Cervilla, Prince, Joels, Russ, & Lovestone, 2004; Hickie et al, 2001; Hwang et al, 2006). Some found depressed APOE4 carriers to have poorer cognitive performance than depressed non-carriers (Hwang et al, 2006; Krishnan et al, 1996), while others found APOE4 unrelated to level of cognitive functioning in depressed older adults (e.g., Hickie et al, 2001). There have been inconsistent findings as to whether having the ε4 allele is related to age of first onset of depression (Krishnan et al, 1996; Hickie et al, 2001; Hwang et al, 2006).…”

Section: Etiology and Risk And Protective Factorsmentioning

confidence: 94%

“…Some found depressed APOE4 carriers to have poorer cognitive performance than depressed non-carriers (Hwang et al, 2006; Krishnan et al, 1996), while others found APOE4 unrelated to level of cognitive functioning in depressed older adults (e.g., Hickie et al, 2001). There have been inconsistent findings as to whether having the ε4 allele is related to age of first onset of depression (Krishnan et al, 1996; Hickie et al, 2001; Hwang et al, 2006). Finally, one study reported that APOE4 in depressed older adults was related to history of suicide attempts (Hwang et al, 2006).…”

Section: Etiology and Risk And Protective Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Depression in Older Adults

Fiske

Wetherell²,

Gatz³

2009

Annu. Rev. Clin. Psychol.

1,889

1,400

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Depression is less prevalent among older adults than among younger adults but can have serious consequences. Over half of cases represent a first onset in later life. Although suicide rates in the elderly are declining, they are still higher than in younger adults and more closely associated with depression. Depressed older adults are less likely to endorse affective symptoms and more likely to display cognitive changes, somatic symptoms, and loss of interest than are younger adults. Risk factors leading to the development of late life depression likely comprise complex interactions among genetic vulnerabilities, cognitive diathesis, age-associated neurobiological changes, and stressful events. Insomnia is an often overlooked risk factor for late life depression. We suggest that a common pathway to depression in older adults, regardless of which predisposing risks are most prominent, may be curtailment of daily activities. Accompanying self-critical thinking may exacerbate and maintain a depressed state. Offsetting the increasing prevalence of certain risk factors in late life are age-related increases in psychological resilience. Other protective factors include higher education and socioeconomic status, engagement in valued activities, and religious or spiritual involvement. Treatments including behavioral therapy, cognitive behavioral therapy, cognitive bibliotherapy, problem-solving therapy, brief psychodynamic therapy, and life review/reminiscence therapy are effective but too infrequently used with older adults. Preventive interventions including education for individuals with chronic illness, behavioral activation, cognitive restructuring, problem-solving skills training, group support, and life review have also received support.

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Section: Etiology and Risk And Protective Factorsmentioning

confidence: 94%

Section: Etiology and Risk And Protective Factorsmentioning

confidence: 99%

Depression in Older Adults

Fiske

Wetherell²,

Gatz³

2009

Annu. Rev. Clin. Psychol.

1,889

1,400

View full text Add to dashboard Cite

show abstract

“…Figure 1 summarizes the process for selecting eligible studies. In total, 20 articles [11][12][13][14][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] that consisted of 6131 subjects (2286 patients and 3845 controls) were included, of which two articles [33,34] reported the number of each allele. Of the 20 studies there were 12 from Asian populations and eight from Caucasian populations.…”

Section: Statistical Analysesmentioning

confidence: 99%

Association between apolipoprotein E gene polymorphism and depression

Feng

et al. 2015

Journal of Clinical Neuroscience

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“…Même si quelques études d'association dans la dépression gériatrique suggèrent l'implication des mêmes facteurs géné-tiques que chez les personnes plus jeunes (Jobim et al, 2008), l'histoire de tentative de suicide dans la dépression gériatrique n'était pas associée à des gènes codant pour le BDNF (Hwang et al, 2006a), mais à une faible expression du gène APOE 4 (Hwang et al, 2006b). En outre, le moins bon fonctionnement exécutif des personnes déprimées était associé à davantage d'anomalies microstructurales de la substance blanche dans les régions fronto-limbiques en imagerie fonctionnelle, et à une faible expression du gène codant pour le transporteur à la sérotonine (Alexopoulos et al, 2008).…”

Section: Biochimieunclassified

Le suicide de la personne âgée : existe-t-il des spécificités liées à l’âge ?

Richard‐Devantoy

Jollant

2013

smq

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Le suicide de la personne âgée pose la question de notre relation à la vieillesse et à la mort. Significativement lié à la dépression, il est relativement élevé dans cette tranche d’âge. Les conduites suicidaires de la personne âgée présentent des particularités cliniques : une intentionnalité et une létalité suicidaire élevées, peu d’antécédents personnels de conduites suicidaires et un faible niveau d’impulsivité et d’agressivité. La vulnérabilité suicidaire pourrait reposer sur des mécanismes étiopathogéniques à la fois communs et différents selon l’âge. Par exemple, il y aurait une prépondérance des facteurs développementaux précoces marqués par de l’impulsivité et de l’agressivité chez l’adolescent et le jeune adulte ; chez l’adulte âgé, il y aurait un vieillissement pathologique. Des déficits neurocognitifs similaires conduisent le sujet à ne pas pouvoir répondre adéquatement à son environnement, différent selon l’âge. La comparaison directe des sujets jeunes et âgés est nécessaire pour comprendre la genèse de la vulnérabilité suicidaire. Nous conclurons cet article avec un résumé des principes de reconnaissance et de prise en charge du risque suicidaire.Suicide in the elderly raises the question of our relationship with aging and death. Suicide rate is relatively high in this group and is significantly related to depression widely under-diagnosed in the elderly. Suicidal behaviour in the elderly has clinical specificities including high intentionality and lethality, usually little personal history of suicidal behaviour and low levels of impulsivity—aggression. Suicidal vulnerability could rely on etiopathogenic mechanisms both common and different according to age; for example, a preponderance of early developmental factors and impulsivity-aggression in adolescents and young adults vs. pathological aging in older adults, but partly similar neurocognitive deficits leading individuals not to respond adequately to their environment (itself different with age). Direct comparisons between elderly and younger subjects would be required. The article concludes with a summary of the principles of recognition and management of suicide risk

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Association of APOE Genetic Polymorphism with Cognitive Function and Suicide History in Geriatric Depression

Cited by 38 publications

References 59 publications

Depression in Older Adults

Depression in Older Adults

Association between apolipoprotein E gene polymorphism and depression

Le suicide de la personne âgée : existe-t-il des spécificités liées à l’âge ?

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