Association between apolipoprotein E gene polymorphism and depression

Feng, Fan; Lu, Shanshan; Hu, Chao; Gong, Feng-Feng; Qian, Zhiguo; Yang, Haojie; Wu, Yun; Zhao, Yuanyuan; Bi, Peng; Sun, Yehuan

doi:10.1016/j.jocn.2015.02.012

Cited by 37 publications

(25 citation statements)

References 28 publications

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“…The association between APOE and depression in population‐based studies and in dementia patients has been widely investigated in the literature; however, the results between studies are mixed (Panza et al, ; Skoog et al, ). A recent meta‐analysis including 13 studies of late‐life depression found that the APOE ε4 allele significantly increased risk of depression (Feng et al, ). Furthermore, a longitudinal population based analysis found that the APOE ε4 allele was associated with incident minor depression and depression symptom severity over 5 years, even after excluding participants who developed dementia within 9 years (Skoog et al, ).…”

Section: Discussionmentioning

confidence: 99%

Association of Alzheimer's genetic loci with mild behavioral impairment

Andrews

Ismail

Anstey

et al. 2018

American J of Med Genetics Pt B

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Mild behavioral impairment (MBI) describes the emergence of later-life neuropsychiatric symptoms (NPS) as an at-risk state for incident cognitive decline and dementia, and for some as a potential manifestation of prodromal dementia. How NPS mechanistically link to the development of mild cognitive impairment and Alzheimer's disease (AD) is not fully understood, with potential mechanisms including shared risk factors related to both NPS and cognitive impairment, or AD pathology promoting NPS. This is the first exploratory study to examine whether AD genetic loci as a genetic risk score (GRS), or individually, are a shared risk factor with MBI. Participants were 1,226 older adults (aged 72-79; 738 males; 763 normal cognition) from the Personality and Total Health Through Life project. MBI was approximated in accordance with Criterion 1 of the ISTAART-AA diagnostic criteria using a transformation algorithm for the neuropsychiatric inventory. A GRS was constructed from 25 AD risk loci. Binomial logistic regression adjusting for age, gender, and education examined the association between GRS and MBI. A higher GRS and APOE*ε4 were associated with increased likelihood of affective dysregulation. Nominally significant associations were observed between MS4A4A-rs4938933*C and MS4A6A-rs610932*G with a reduced likelihood of affective dysregulation; ZCWPW1-rs1476679*C with a reduced likelihood of social inappropriateness and abnormal perception/thought content; BIN1-rs744373*G and EPHA1-rs11767557*C with higher likelihood of abnormal perception/thought content; NME8-rs2718058*G with a reduced likelihood of decreased motivation. These preliminary findings suggest a common genetic etiology between MBI and traditionally recognized cognitive problems observed in AD and improve our understanding of the pathophysiological features underlying MBI. K E Y W O R D SAlzheimer's disease, genetic risk score, MBI

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Section: Discussionmentioning

confidence: 99%

Association of Alzheimer's genetic loci with mild behavioral impairment

Andrews

Ismail

Anstey

et al. 2018

American J of Med Genetics Pt B

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“…Being a homozygous ε4 carrier increases the risk of developing sporadic AD by a factor 10-20 compared to being an ε3 homozygote [6][7][8]. APOE ε4 has also been implicated in other settings including atherosclerosis [9], depression [10], accelerated progression in multiple sclerosis [11] and brain atrophy in HIV patients [12]. The ε2 allele may be a protective trait, lowering the risk of developing AD [13], as compared to ε3, the most common allele.…”

Section: Introductionmentioning

confidence: 99%

Apolipoprotein E genotypes and longevity across dementia disorders

Skillbäck

Lautner

Mattsson

et al. 2018

Alzheimer's & Dementia

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“…This fact must be considered when carrying out research based on a case-control approach, as the ethnic component can affect the final result. The study reported by Feng et al (2015) 30 showed a significant association between ApoE gene polymorphism and susceptibility to depression in the Caucasian population (ε2 allele versus ε3: OR 0.75, 95% CI 0.58-0.97). In our study, there was no statistically significant difference between the control samples and patients with MDD (χ2 = 7.7, df = 5, P = 0.17) or patients with RDD (χ2 = 5,8, df = 5, P = 0.33) regarding the genotypes of APOE .…”

Section: Discussionmentioning

confidence: 92%

Genetic Analysis of BDNF, GNB3, MTHFR, ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia

et al. 2016

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This study was conducted to explore the possibility of association between the single-nucleotide polymorphisms rs6264 of BDNF, rs5443 of GNB3, and rs1801133 of MTHFR; the In/Del polymorphism of ACE; and the ε2 allele of APOE and major depressive disorder (MDD) and recurrent depressive disorder (RDD) in an East Slavic population. Generalized multifactor dimensionality reduction (GMDR) method was applied to detect gene-gene interactions. One hundred fifty patients with RDD (101 females and 49 males) and 208 patients with MDD (115 females and 93 males) were included in the study. The comparison group consisted of 200 unrelated individuals. There was no significant difference in genotype distributions or allele frequencies between the controls and any of the diagnostic groups. Nevertheless, the frequency of the G allele of rs1801133 of MTHFR was higher in the RDD group and the frequency of the C allele of rs6264 of BDNF was higher in the MDD group. The difference between the controls and specific disease groups almost reached statistical significance (P = 0.08). A GMDR did not reveal optimal two- and three-dimensional models with significant prediction accuracies (P ˃ 0.05) for the MDD or RDD groups.

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Association between apolipoprotein E gene polymorphism and depression

Cited by 37 publications

References 28 publications

Association of Alzheimer's genetic loci with mild behavioral impairment

Association of Alzheimer's genetic loci with mild behavioral impairment

Apolipoprotein E genotypes and longevity across dementia disorders

Genetic Analysis of BDNF, GNB3, MTHFR, ACE and APOE Variants in Major and Recurrent Depressive Disorders in Russia

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