Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis

Abstract

ABSTRACT. Previous studies have reported associations between the functional FABP2 Ala54Thr (rs1799883) polymorphism and type 2 diabetes mellitus (T2DM), obesity, and metabolic syndrome in different populations with conflicting results. We investigated the association between the FABP2 Ala54Thr polymorphism and T2DM (235 cases, 431 controls), obesity (377 cases, 431 controls), and metabolic syndrome (315 cases, 323 controls) by logistic regression analysis in a Chinese study cohort recruited from Yichang, Hubei Province. We then comprehensively reviewed the association of the FABP2 Ala54Thr polymorphism with T2DM, obesity, and metabolic syndrome via meta-analysis. The strength of association was assessed by odds ratios (ORs) with 95% confidence intervals (CIs). The FABP2 Ala54Thr polymorphism was significantly associated with obesity (AT vs AA:Y. Liu et al. 1156©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 1155-1168 (2015) OR = 2.633, 95%CI = 1.065-6.663, P = 0.036; TT vs AA: OR = 4.160, 95%CI = 1.609-10.757, P = 0.003) and metabolic syndrome (TT vs AA: OR = 2.273, 95%CI = 1.242-4.156, P = 0.008) by logistic regression with adjustment for covariates. However, no significant association was found between T2DM and the FABP2 Ala54Thr polymorphism. We identified 24 studies on T2DM (4517 cases, 5224 controls), 9 studies on obesity (949 cases, 2002 controls), and 6 studies on metabolic syndrome (2194 cases, 3282 controls) by literature search. The metaanalyses revealed significant associations for metabolic syndrome (T allele: OR = 1.179, 95%CI = 1.015-1.362, P = 0.031) and T2DM (T allele: OR = 1.160, 95%CI = 1.08-1.24, P < 0.001), but no association for obesity (T allele: OR = 1.069, 95%CI = 0.925-1.235, P = 0.367).

The fatty acid binding protein 2 (FABP2) polymorphism Ala54Thr and obesity in Pakistan: A population based study and a systematic meta-analysis

“…This is in contrast to a previous meta-analysis performed on global populations by Zhao et al [42] who found no association between obesity and the polymorphism, however another meta-analysis by Liu et al performed recently, significant association between the polymorphism and obesity was found after adjusting for covariates (age, gender, blood pressure and fasting serum insulin) [29].…”

“…following information was retrieved from the selected studies: Authors names, Publication year, Sample size, Number of cases and controls, Age and gender of subjects, Sample ethnicity, allele/genotype frequencies in cases and controls, confidence intervals, odds ratios, and p-values. We identified 5 studies using this search [25][26][27][28][29] (Figure 1). The total number of controls and cases included in meta-analysis was 1519 and 2025, respectively, including our study.…”

Genetic association of APOA5 and APOE with metabolic syndrome and their interaction with health-related behavior in Korean men

“…A total of 17 SNPs with a MAF of less than 0.05 in the Asian HapMap (CHB + JPT) were selected to test associations with MetS and its components (Additional file 1 : Table S1). Among selected SNPs, PPARG rs1801281, APOA5 rs662799, rs2266788 CETP rs708272, rs1800775 GNB3 rs5433, APOE rs769450, rs7412 FABP2 rs1799883 and ENPP1 rs1044498 are involved in lipid metabolism [ 9 , 19 , 25 , 34 – 36 ]. Some of these SNPs are also involved in weight regulation, glucose metabolism and blood pressure regulation.…”

Gene Polymorphisms of FABP2, ADIPOQ and ANP and Risk of Hypertriglyceridemia and Metabolic Syndrome in Afro-Caribbeans

“…As a result, higher fasting plasma levels of cholesterol and TG (especially in postprandial stage) were found in subjects carrying the Thr54 mutation [ 26 ]. This excessive level of fatty acids (associated with the Thr54) and their preferential use as a source of energy by skeletal muscle rather than glucose, contribute to an increase in glucose levels, higher basal and glucose-stimulated insulin levels and higher degree of insulin resistance [ 2 , 14 , 23 ]. Significant associations between the FABP2 Ala54Thr polymorphism and MetS components or MetS were reported in some studies [ 3 , 14 , 26 ] whereas some others found no association [ 27 ].…”

“…These polymorphisms were chosen because of different data from the literature: significant associations between rs1799883 and MetS [ 14 ], association of rs1501299 with the concomitant presence of MetS and hypertension in a Taiwanese population [ 15 ], and association of rs5065 with diabetic complications and cardiovascular disease [ 12 , 13 ]. In addition, previous studies in relation with cardiometabolic risk were conducted for rs1501299 and rs5065 in our Afro-Caribbean diabetic population with and without history of CAD [ 16 , 17 ], and in descendants of Indian migrants living in Guadeloupe for rs1799883 [ 18 ].…”