Association of the genetic markers for myocardial infarction with sudden cardiac death

Abstract

Polymorphisms rs1333049 and rs10757278 are associated with SCD in men and rs499818 in the women aged over 50 years.

Complex Evaluation of the Significance of Populational Genetic Markers Associated With Myocardial Infarction and Risk Factors

“…Это свидетельствует о выбывании "генотипов риска" из популяции с воз-растом. rs1333049 и rs10757278, расположенные на 9-й хро-мосоме, в нашем исследовании были полностью сце-плены [10]. Вследствие этого, нами представлен один из них, а именно rs1333049.…”

“…1 и 2). Но в группе женщин старше 50 лет с повышенным риском разви-тия ВСС ассоциирован генотип AG rs499818 (р=0,009, OR =2,4, 95% CI 1,3-4,6) [10]. У мужчин из контроль-ной группы отмечено повышение индекса массы тела (ИМТ) в ряду генотипов GG, AG, AA.…”

A Bitter Taste in Your Heart

“…There are 132 naturally occurring non-synonymous polymorphisms for cardiac-expressed T2Rs and it is clear that the majority of these remain uncharacterized (Table 3). One polymorphism that is of particular interest is T2R50-rs1376251, as debate remains in the literature over its potential association with myocardial infarction and coronary heart disease (Shiffman et al, 2008;Tepper et al, 2008;Yan et al, 2009;Koch et al, 2011;Ivanova et al, 2017;Tsygankova et al, 2017). There are also polymorphisms outside of the taste receptor coding region, or those that result in synonymous mutations that have been associated with changes in physiology.…”

Single nucleotide polymorphisms in long noncoding RNA, ANRIL, are not associated with severe periodontitis but with adverse cardiovascular events among patients with cardiovascular disease

“…Another ANRIL SNP, rs1333049, was characterized as a lead SNP for CVD . Many different studies, of populations comprising several ethnicities, prove the association of rs1333049 with myocardial infarction (MI), sudden cardiac death, multivessel disease, as well as high systolic blood pressure …”