Association of the human leukocyte antigen class II alleles with chronic atrophic gastritis and gastric carcinoma in Koreans

Abstract

OBJECTIVE:Gastric carcinogenesis is a multi-step process and is influenced by several etiological agents, including the host's genetic factors. Since whether a patient remains with chronic superficial gastritis (CSG) or progresses to either chronic atrophic gastritis (CAG) or gastric carcinoma (GC) could be a genetic predisposition unique in each population, we hypothesized that host human leukocyte antigen (HLA) alleles could be discriminative in predicting the risk of CSG progression to precancerous CAG and GC in Koreans. METHODS:A total of 165 patients with gastric disorders (CSG, 62; CAG, 69 and GC, 34), were selected to investigate the association of HLA class II alleles with the progression of CSG to CAG or GC. HLA genotypes were obtained by the polymerase chain reaction-sequence based typing method. RESULTS:The phenotypic frequencies of DRB1*1101 and DQA1*0505 were significantly higher in the CAG group compared to those in the CSG group. In the subjects with Helicobacter pylori (H. pypori) (+), the frequencies of DRB1*1501 and DQB1*0602 were significantly lower in the CAG compared to those in the CSG. Further analysis showed that sex (P < 0.05, OR = 0.41-0.42) and age (P < 0.05, OR = 1.05) also affected the risk of progression from CSG to CAG in H. pylori (+) patients carrying the DRB1*1501 or DQB1*0602 allele. Additionally, the frequency of DRB1*0404 in the GC group was significantly higher than that in the gastritis group. CONCLUSION:Our findings strongly imply an association between HLA class II alleles and the risk of CAG development and GC progression in Koreans.

Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5

“…28,29 Moreover, different HLA alleles may be contribute to development and progression of gastric cancer in the diverse ethnic groups. 27 …”

“…The distribution of HLA alleles and the linkage disequilibrium among alleles from diverse HLA gene differ in various ethnic populations. 26,27 In addition, relatively small populations were included in several studies. Third, the different antibody, immunostaining method, and scoring system may have contributed to discrepancies.…”

Evaluation of Human Leukocyte Antigen Class I and Ii Antigens in Helicobacter Pylori-Positive Pediatric Patients With Active Gastritis and Duodenal Ulcer

“…Recent studies have supported the hypothesis that genetic predisposition associated with human leukocyte antigen (HLA) genes have a role in the development of gastric cancer. In H. pylori-positive gastric cancers, studies especially conducted on class II HLA-DRB1* and HLA-DQB1* antigens attract attention (5,7) . To our knowledge, there are no studies on tissue groups in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer in Turkish population.…”

Systematic identification of immunodominant CD4+ T cell responses to HpaA inHelicobacter pyloriinfected individuals

“…The HpaA88-100 specific CD4 + T cell response was found to be associated with resistance to severe gastric diseases correlated to H. pylori infection in HLA-DRB1*1501 positive subjects [20]. A negative association with HLA-DRB1*1501 allele, reported in H. pylori -positive patients with gastric ulcers when compared with uninfected healthy controls, further supported this potential protective role mediated by HLA-DRB1*1501 restricted HpaA88-100 specific CD4 + T cell response [30, 31]. Here, we demonstrated that it was not the broad of peptide specificity, but the strength of HpaA specific CD4 + T cell responses was associated with gastric diseases potentially caused by H. pylori infection (Figure 5).…”