Association of the <i>CALM1</i> Core Promoter Polymorphism with Knee Osteoarthritis in Patients of Greek Origin

Poulou, Myrto; Kaliakatsos, Marios; Tsezou, Aspasia; Kanavakis, Emmanuel; Malizos, Konstantinos N.; Tzetis, Maria

doi:10.1089/gte.2007.0114

Cited by 23 publications

(20 citation statements)

References 11 publications

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“…Moreover, asporin was found to be associated with hand OA in the Netherlands 27 . An association with D-repeat polymorphisms was also confirmed for knee OA in a Greek population 28,29 . Further, other alleles (D12, D15, or D16) were associated with OA either as a risk factor or a protective factor in Mexican 30 and Iranian 31 study populations.…”

Section: Involvement Of Asporin In Oa Pathogenesismentioning

confidence: 61%

Asporin and osteoarthritis

Liu

et al. 2015

Osteoarthritis and Cartilage

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Studies examined demonstrate the involvement of asporin in OA pathogenesis, and possible mechanisms by which asporin may be involved in this process have been proposed. However, large-scale interracial studies should be conducted to investigate the association between asporin and OA, and further investigations are needed to obtain a better understanding of the disease mechanism, develop novel therapeutic strategies, and explore new approaches for diagnosis of OA.

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Section: Involvement Of Asporin In Oa Pathogenesismentioning

confidence: 61%

Asporin and osteoarthritis

Liu

et al. 2015

Osteoarthritis and Cartilage

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“…In the last decade, many studies have been published exploring the role of several SNPs in OA pathogenesis in Greek populations . To the best of our knowledge, this is the first study that evaluates the role of the ‐1607 1G/2G polymorphism (rs1799750) of the MMP‐1 gene in the pathogenesis of knee OA in the Greek population.…”

Section: Discussionmentioning

confidence: 99%

Association ofMMP-1-1607 1G/2G (rs1799750) polymorphism with primary knee osteoarthritis in the Greek population

et al. 2014

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Osteoarthritis is the most common form of arthritis with still unknown pathogenic etiology and considerable contribution of genetic factors. One of the mechanisms of cartilage degradation in osteoarthritis is enzymatic proteolysis of the extracellular matrix by metalloproteinases. MMP-1, produced by chondrocytes and synovial cells, is a major proteinase of the MMPs family. The present study aims at evaluating the association of MMP1 gene -1607 1G/2G (rs1799750) polymorphism with primary knee osteoarthritis in the Greek population. One hundred fifty five patients with primary symptomatic knee osteoarthritis participated in the study along with 139 controls. Genotypes were determined using PCR-RLFP technique. Allelic and genotypic frequencies were compared between both study groups. There was no significant association between MMP1 -1607 1G/2G polymorphism and knee osteoarthritis, in crude analysis; however, after multiple logistic regression analysis, 1G/2G was associated with reduced odds of knee osteoarthritis by 75% in males, compared to genotypes 1G/1G þ 2G/2G, adjusting for age and BMI (adjusted OR: 0.25, 95% CI: 0.069, 0.910, p ¼ 0.035). The present study shows that MMP1 -1607 1G/2G (rs1799750) polymorphism might be a risk factor for knee osteoarthritis susceptibility in the Greek population. Further investigations are needed to confirm this association in the pathogenesis of osteoarthritis. ß

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“…The protein thus affects the chondrocyte response to mechanical load (Poulou et al, 2008). A CALM1 single nucleotide polymorphism was reported to be associated with hip OA in Japanese individuals.…”

Section: +mentioning

confidence: 99%

Protein interaction and microRNA network analysis in osteoarthritis meniscal cells

Wang¹,

Liu²,

Zhang³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Osteoarthritis is the most common form of arthritis among elderly adults. Herein, we performed protein-protein interaction (PPI) and miRNA network analysis to evaluate the global correlation between miRNA regulation and the PPI network in human osteoarthritis. Our results showed that desmoplakin (DSP), cystatin A (CSTA), calmodulin 1, tyrosine kinase endothelial, insulin-like growth factor 1 (IGF-1), IGF-binding protein 7 (IGFBP7), syndecan 1 (SDC1), ephrin type-A receptor 4, and PDZ and LIM domain protein 1 were associated with osteoarthritis. Among these proteins, DSP and CSTA interaction and IGF-1, IGFBP7 and SDC1 interaction were observed in our PPI network. Furthermore, these potential target proteins were also linked with individual miRNA in the network. Our findings shed light on the PPIs and mechanisms by which miRNA may regulate the protein interaction network in osteoarthritis, which might provide theoretical support for further studies aimed at discovering new therapeutic strategies.

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Association of the CALM1 Core Promoter Polymorphism with Knee Osteoarthritis in Patients of Greek Origin

Abstract: Our data implied that the -16TT (rs12885713) CALM1 core promoter genotype is not a risk factor for OA etiology in Greek Caucasians on its own, but associated with the Asporin (ASPN) D14 or D15 risk allele, it could influence KOA susceptibility.

Cited by 23 publications

References 11 publications

Asporin and osteoarthritis

Asporin and osteoarthritis

Association ofMMP-1-1607 1G/2G (rs1799750) polymorphism with primary knee osteoarthritis in the Greek population

Protein interaction and microRNA network analysis in osteoarthritis meniscal cells

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