Association of the plasma riboflavin levels and riboflavin transporter (C20orf54) gene statuses in Kazak esophageal squamous cell carcinoma patients

Ainiwaer, Julaiti; Tuerhong, Abuduaini; Hasim, Ayshamgul; Chengsong, Du; Zhang, Liwei; Sheyhidin, Ilyar

doi:10.1007/s11033-012-2453-7

Cited by 14 publications

(9 citation statements)

References 22 publications

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“…Some findings suggested that riboflavin at high doses might promote lung cancer progression (Yang et al, 2013). Defective expression of C20orf54 gene statuses is associated with the development of esophageal squamous cell carcinoma and this may represent a mechanism underlying the decreased plasma riboflavin levels in ESCC (Ainiwaer et al, 2013). Decreased blood riboflavin levels are correlated with defective expression of RFT2 gene in gastric cancer (Eli et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Liu¹,

Yu²,

Zhu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 16 (3), 909-913 IntroductionIn 2013, colorectal cancer was newly diagnosed in 73,680 males in the United States; 26,300 died of the disease. It was newly diagnosed in 69,140 females and 24,530 died (Siegel et al., 2013). Indeed, colorectal cancer is the third most commonly diagnosed cancer in males and the second in females, with more than 1.2 million new cases and 608,700 deaths estimated to have occurred in 2008 (Center et al., 2009.Vitamin B2 (chemical formula: C17H20N4O6) also known as riboflavin . In fact, the flavin in riboflavin comes from flavus, the Latin word for yellow. (yellow enzymes play a role of hydrogen in the biological oxidation reduction). Vitamin B2 is one of many nutrients required to recycle glutathione, which is one of the most important antioxidants in the human body. (From a chemical standpoint, what B2 does is facilitate the conversion of oxidized glutathione into reduced glutathione.) (Yasuda and Hiraoka, 1999).Riboflavin is unique among the water-soluble vitamins in that milk and dairy products make the greatest contribution to its intake in Western diets. Meat and fish are also good sources of riboflavin, and certain fruit and vegetables, especially dark-green vegetables, contain reasonably high concentrations (Powers, 2003). Vitamin B2 has limited storage , So it need a food supplement Conclusions: This is the first meta-analysis to study links between vitamin B2 and colorectal cancer. We found vitamin B2 intake was inversely associated with risk of colorectal cancer. However, further research and large sample studies need to be conducted to better validate the result.

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Section: Discussionmentioning

confidence: 99%

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Liu¹,

Yu²,

Zhu³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Because of the theoretical relationship between gene promoter hypermethylation as an epigenetic modification with the down regulation of gene transcription, we analyzed hRFT2, due to the down regulation of these genes in ESCC and GC (Maynur et al, 2012;Julaiti et al, 2012). Map CpG-rich islands within the hRFT2 regulatory region by professional software with bisulfate sequencing primers, which used to amplify the gene promoter region sequences that are spanning 3 kb around the transcription start site.…”

Section: Methylation Profiles Of the Hrft2 Gene In Sihamentioning

confidence: 99%

“…Decreased protein expression of hRFT2 is related to malignant progression both esophageal squamous cell carcinoma and gastric cancer (Pangrekar et al, 1993), due to the hRFT2 is responsible for transporting riboflavin and riboflavin deficiency has been reported as a risk factor for cancer. Relatively speaking that alter expression of hRFT2 is the most important factors contributing to transporting and absorption of riboflavin in the intestinal (Maynur et al, 2012), whereas the Riboflavin deficiency can cause a variety of metabolic problems that lead to skin and mucosal disorders (Julaiti et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Regulation of Human Riboflavin Transporter 2(hRFT2) in Cervical Cancers from Uighur Women

Kurban²,

Zhao³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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In the present study, we studied the hypermethylation of the human riboflavin transporter 2 (hRFT2) gene and regulation of protein expression in biopsies from resected tissues from Uighur cervical squamous cell carcinoma (CSCC) patients and their neighboring normal tissues. hRFT2 gene promoter region methylation sequences were mapped in cervical cancer cell line SiHa by bisulfite-sequencing PCR and quantitative detection of methylated DNA from 30 pairs of Uighur's CSCCs and adjacent normal tissues by MassARRAY (Sequenom, San Diego, CA, USA) and hRFT2 protein expression was analyzed by immunohistochemistry. In SiHa, we identified 2 CG sites methylated from all of 12CpG sites of the hRFT2 gene. Analysis of the data from quantitative analysis of single CpG site methylation by Sequenom MassARRAY platform showed that the methylation level between two CpG sites (CpG 2 and CpG 3) from CpG 1~12 showed significant differences between CSCC and neighboring normal tissues. However, the methylation level of whole target CpG fragments demonstrated no significant variation between CSCC (0.476±0.020) and neighboring normal tissues (0.401±0.019, p>0.05). There was a tendency for translocation the hRFT2 proteins from cytoplasm/membrane to nucleus in CSCC with increase in methylation of CpG 2 and CpG 3 in hRFT2gene promoter regions, which may relate to the genesis of CSCC. Our results suggested that epigenetic modifications are responsible for aberrant expression of the hRFT2 gene, and may help to understand mechanisms of cervical carcinogenesis.

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“…C20orf54 has been identified as an ESCC susceptibility gene [ 7 ]; however, the expression of C20orf54 in ESCC is inconsistent. The gene is lower in ESCC tissues compared with normal tissues [ 10 ]. By contrast, Lu et al [ 11 ] showed that the C20orf54 protein level in ESCC tissues was significantly higher than that in adjacent normal tissues.…”

Section: Introductionmentioning

confidence: 99%

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection

Kong²,

Wang

et al. 2022

World J Surg Onc

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Background C20orf54 has been identified as an esophageal squamous cell carcinoma (ESCC) susceptibility gene in previous genome-wide association studies. Here, we attempted to clarify the expression level of C20orf54 in ESCC, non-tumoral esophageal tissues, and esophageal squamous intraepithelial neoplasia (ESIN). Methods We assessed C20orf54 expression in 146 ESCC, 108 non-tumoral esophageal tissues, and 148 ESIN using immunohistochemistry on tissue microarrays. We also evaluated the possible correlations of C20orf54 expression with clinicopathological characteristics. The survival rates were analyzed using the Kaplan-Meier method and log-rank test. Results C20orf54 expression was significantly lower in ESCC, high-grade ESIN, and low-grade ESIN than in the non-tumoral esophageal tissues. The level observed for ESCC was also significantly lower than that in low-grade ESIN and high-grade ESIN, whereas no difference was observed between high-grade ESIN and low-grade ESIN. Furthermore, the C20orf54 defective expression correlated significantly with differentiation, lymph node metastasis, and invasion depth. The overall survival time was inversely associated with lymph node metastasis, an advanced TNM stage (III + IV), and deeper invasion. Conclusions This study provides the first evidence of C20orf54 defective expression in ESCC and precancerous lesions, demonstrating a potential role in tumor progression and metastasis. C20orf54 could be used as a potential biomarker for the early detection of ESCC.

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Association of the plasma riboflavin levels and riboflavin transporter (C20orf54) gene statuses in Kazak esophageal squamous cell carcinoma patients

Cited by 14 publications

References 22 publications

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Vitamin B2 Intake and the Risk of Colorectal Cancer: a Meta-Analysis of Observational Studies

Epigenetic Regulation of Human Riboflavin Transporter 2(hRFT2) in Cervical Cancers from Uighur Women

Defective expression of C20orf54 in esophageal dysplasia: a possible biomarker of esophageal carcinoma for early detection

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