Association of the rs3077 and rs9277535 polymorphisms in<i>HLA-DP</i>with hepatitis B virus infection and spontaneous clearance: A meta-analysis

Zhang, Xiaolin; Ni, Xiaochen; Jia, Jinhai; Dong, Jiajia; Yu, Fei; Ma, Ning; Li, Xuehui; Li, Man; Liu, Dianwu

doi:10.3109/00365521.2013.787643

Cited by 20 publications

(10 citation statements)

References 23 publications

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“…As compared with rs9277535 GG genotype, the multivariate-adjusted ORs were 0.46 (95% CI, 0.39-0.56) and 0.62 (95% CI, 0.57-0.68) for AA and AG genotypes, respectively. 30 In the present GWAS study, the rs9277535 A allele was correlated with a lower risk of nonresponse to booster HB vaccination, which was consistent with previous findings.…”

Section: Discussionsupporting

confidence: 92%

“…A recent meta‐analysis estimated that the multivariate‐adjusted ORs of HBV chronic infection for rs3077 AA and AG genotypes were 0.42 (95% CI, 0.30–0.59) and 0.60 (95% CI, 0.46–0.78), respectively, in comparison with rs3077 GG genotype. As compared with rs9277535 GG genotype, the multivariate‐adjusted ORs were 0.46 (95% CI, 0.39–0.56) and 0.62 (95% CI, 0.57–0.68) for AA and AG genotypes, respectively . In the present GWAS study, the rs9277535 A allele was correlated with a lower risk of nonresponse to booster HB vaccination, which was consistent with previous findings.…”

Section: Discussionsupporting

confidence: 91%

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SNP rs7770370 in HLA‐DPB1 loci as a major genetic determinant of response to booster hepatitis B vaccination: Results of a genome‐wide association study

Chen

Lai

et al. 2015

J of Gastro and Hepatol

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

SNP rs7770370 in HLA‐DPB1 loci as a major genetic determinant of response to booster hepatitis B vaccination: Results of a genome‐wide association study

Chen

Lai

et al. 2015

J of Gastro and Hepatol

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“…Several lines of evidence and two recent meta‐analyses indicate that host genetics predicts spontaneous clearance of HBV among Asian patients . The stronger association is with SNPs in the HLA Class II locus, which is in line with the overall understanding of a genetic predisposition influencing the evolution of HBV infection.…”

Section: Discussionsupporting

confidence: 59%

Systematic review with meta‐analysis: do interferon lambda 3 polymorphisms predict the outcome of interferon‐therapy in hepatitis B infection?

Galmozzi

Viganò

Lampertico

2014

Aliment Pharmacol Ther

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Summary Background Interferon lambda 3 (IFN‐λ3) polymorphisms are the strongest genetic predictor of outcome of hepatitis C virus infection and of response to Pegylated interferon (PegIFN)‐based therapy. Whether this holds true for hepatitis B virus (HBV) infection is matter of controversy. Aim To review the association between host genomics and spontaneous or interferon‐induced clearance of HBV with specific reference to the recently identified interleukin 28B gene now renamed IFN‐λ3. Methods A literature search was performed on MEDLINE, EMBASE and Web of Science for English articles and abstracts using free text words and combinations of the following terms ‘IL28B’, ‘IFN lambda’, ‘genomics’, ‘hepatitis B virus’, ‘interferon’ ‘GWAS’, ‘treatment’, ‘SNPs’, ‘HLA’, ‘polymorphisms’. Results Genome‐wide association studies convincingly demonstrated an association between SNPs in the HLA locus and spontaneous resolution of HBV infection in subgroups of Asian patients, yet no information is available for Caucasians. The preliminary observations of an association between IFN‐λ3 SNP and virological and serological responses to IFN in both HBeAg‐positive and ‐negative patients could not be replicated by subsequent studies. Yet, majority of studies performed so far suffer several limitations in terms of sample size, selection of the patients, endpoints of therapy, treatment strategies and duration of follow‐up. Conclusions While host genetics is associated with an increased likelihood of spontaneous clearance of HBV among genotype B/C patients, the relationship between IFN‐λ3 polymorphisms and response to IFN has not been confirmed. Further studies in large cohorts of homogeneous patients are required, before this genetic test can be recommended in clinical practice.

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“…Compared with the previous meta-analysis 52 , the present study is much larger, with more than three times as many subjects as the earlier study. In addition, we assessed not only the effect on HBV infection and viral clearance but also the effects on HBV activity and HCC development.…”

Section: Discussionmentioning

confidence: 73%

Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development

Liu

Cheng

et al. 2015

Sci Rep

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Hepatitis B virus (HBV) infection is the predominant risk factor for chronic hepatitis B (CHB), liver cirrhosis (LC) and hepatocellular carcinoma (HCC). Recently, genome-wide association studies have identified human leukocyte antigen (HLA)-DP polymorphisms (rs3077 and rs9277535) as a new chronic HBV infection susceptibility locus. Since then, the relationship between HLA-DP polymorphisms and various outcomes of HBV infection has been reported. However, the results have been inconclusive. To derive a more precise estimation of the relationship between HLA-DP polymorphisms and various outcomes of HBV infection, a meta-analysis of 62,050 subjects from 29 case-control studies was performed. We found that rs3077 and rs9277535 in HLA-DP significantly decreased HBV infection risks and increased HBV clearance possibility in a dose-dependent manner. In the subgroup analysis by ethnicity, study design and sample size, significant associations were found for these polymorphisms in almost all comparisons. Meanwhile, haplotype analyses of the two polymorphisms revealed a significant association between the combination of these alleles and HBV infection outcomes. However, no significant results were observed in HCC development. Our results further confirm that genetic variants in the HLA-DP locus are strongly associated with reduced HBV infection and increased the likelihood of spontaneous viral clearance.

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Association of the rs3077 and rs9277535 polymorphisms inHLA-DPwith hepatitis B virus infection and spontaneous clearance: A meta-analysis

Abstract: Our results demonstrated that the rs3077 and rs9277535 HLA-DP polymorphisms reduced HBV infection and increased the likelihood of spontaneous viral clearance in some Asian populations.

Cited by 20 publications

References 23 publications

SNP rs7770370 in HLA‐DPB1 loci as a major genetic determinant of response to booster hepatitis B vaccination: Results of a genome‐wide association study

SNP rs7770370 in HLA‐DPB1 loci as a major genetic determinant of response to booster hepatitis B vaccination: Results of a genome‐wide association study

Systematic review with meta‐analysis: do interferon lambda 3 polymorphisms predict the outcome of interferon‐therapy in hepatitis B infection?

Quantitative assessment of common genetic variations in HLA-DP with hepatitis B virus infection, clearance and hepatocellular carcinoma development

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