Association of Tissue-Fixed Cytoplasmic Deposits of Immunoglobulin in Epidermal Keratinocytes With Lupus Erythematosus

Ioannides, Demetris; Bystryn, Jean‐Claude

doi:10.1001/archderm.1993.01680300058008

Cited by 10 publications

(2 citation statements)

References 19 publications

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“…In addition, in our case we noted cytoid body antibodies with Complement/C3c, fibrinogen and subcorneal antibodies that are not classically described in lupus. We observed tissue fixed deposits of immunoglobulin M present in the cytoplasm of epidermal keratynocytes; however, instead of the 3 reported patters described in normal skin [8,9], our reactivity was present throughout the entire epidermis. Also remarkable was the reactivity to some type(s) of likely cell junctions in the epidermis and dermis, best appreciated with anti-Complment/C3c and fibrinogen.…”

Section: Discussioncontrasting

confidence: 80%

A transient drug induced lupus erythematosus – like allergic drug reaction with multiple antibodies

Velez¹,

Brown²,

Howard³

2013

Our Dermatol Online

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Drug reactions may mimic several dermatoses, including lupus erythematosus. We present an 80 year old female patient on multiple medications, who presented with blisters on her hands and arms for two weeks, which then generalized to the rest of her body. The patient was evaluated by a dermatologist, and biopsies for hematoxylin and eosin (H&E) examination, as well as for direct immunofluorescence (DIF) and immunohistochemistry (IHC) were performed. The H&E biopsy examination revealed a mild, superficial, perivascular dermal infiltrate of lymphocytes, histiocytes and abundant eosinophils; neutrophils were rare. No vasculitis was noted. DIF revealed positive basement membrane (BMZ) staining, primarily with patchy Complement/C3c and fibrinogen; in addition, strong reactivity to dermal blood vessel was appreciated. Antibodies to cell junction-like structures were also noted in the epidermis and dermis with these two antibodies. IHC using similar immunoglobulins and complement components showed similar patterns. We observed that contrary to lupus erythematosus, neither IgG nor IgM were positive at the BMZ.

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Section: Discussioncontrasting

confidence: 80%

A transient drug induced lupus erythematosus – like allergic drug reaction with multiple antibodies

Velez¹,

Brown²,

Howard³

2013

Our Dermatol Online

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“…Dr. Bystryn was one of the first who appreciated the heterogeneity of pemphigus and pemphigoid antigens and regional variation in their expression [9‐12]. His laboratory also contributed to immunohistochemical characterization of lupus antigens [13‐16], and the immunologic components of Grover’s disease [17], lichen planopilaris [18] and vitiligo [19]. His group detected antibodies to melanocytes in vitiligo [20,21], characterized some vitiligo antigens [22,23] and established correlation between vitiligo antibodies and extent of depigmentation [24].…”

mentioning

confidence: 99%

Jean-Claude Bystryn 1938-2010. An obituary

Grando

Holubar

Schwartz

2010

Experimental Dermatology

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Jean-Claude Bystryn, M.D., passed away on 19 August, 2010. Dr. Bystryn's research interests encompassed a large group of dermatologic conditions. He has earned a worldwide recognition for his innovative works on autoimmune blistering diseases, melanoma and alopecia areata. The most significant impact Dr. Bystryn's research has made is on our understanding of the mechanisms of epidermal cell detachment (acantholysis) in pemphigus and development of adequate treatment. During the last decade, he chaired the Medical Advisory Board of the International Pemphigus and Pemphigoid Foundation. Dr. Bystryn was an innovative physician-scientist whose scientific contributions will be long recalled and admired both by patients and colleagues.

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Antibodies Inside Our Keratinocytes?

Sontheimer¹

1993

Arch Dermatol

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Association of Tissue-Fixed Cytoplasmic Deposits of Immunoglobulin in Epidermal Keratinocytes With Lupus Erythematosus

Cited by 10 publications

References 19 publications

A transient drug induced lupus erythematosus – like allergic drug reaction with multiple antibodies

A transient drug induced lupus erythematosus – like allergic drug reaction with multiple antibodies

Jean-Claude Bystryn 1938-2010. An obituary

Antibodies Inside Our Keratinocytes?

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