Association of TLR3 (rs3775291) and IL-10 (rs1800871) gene polymorphisms with susceptibility to Hepatitis B infection: A meta-analysis

Abstract

TLR3 and IL-10 play a crucial role in antiviral defence. However, there is a controversy between TLR3 rs3775291 and IL-10 rs1800871 polymorphisms and the risk of hepatitis B virus (HBV) infection. The purpose of this study is to explore the relationship between the two single nucleotide mutations and the risk of HBV infection by meta-analysis. Medline, EMBASE, Web of Science, CNKI, China Wanfang database were searched for the case-control studies on the relationship between TLR3 rs3775291 and IL-10 rs1800871 polymorphism and susceptibility to HBV, updated to June 2020. The data were analysed by Stata 15.0 software. A total of 22 articles were included. The results showed that in the analysis of IL10 rs1800871 polymorphism and the risk of HBV infection, the pooled OR was 1.21 (95% CI 1.06-1.37), 1.28 (95% CI 1.04-1.56) and 1.20 (95% CI 1.06-1.37) and 1.40 (95% CI 1.07-1.83) in the allele model (C vs. T), dominant model (CC+CT vs. TT), recessive model (CC vs. CT+TT) and homozygous model (CC vs. TT), respectively. There was no statistical significance in the heterozygote model. A subgroup analysis of the Asian population showed similar results. The analysis of TLR3 rs3775291 polymorphism and the risk of HBV showed that in the allele model (T vs. C), the pooled OR was 1.30 (95% CI 1.05-1.61). Except for the recessive model, no significances were found in other genetic models. In conclusion, TLR3 rs3775291 and IL-10 rs1800871 polymorphisms are associated with the risk of HBV. Allele C and genotype CC at IL10 rs1800871 loci, as well as allele T and genotype TT at TLR rs3775291 loci, may increase susceptibility to Hepatitis B infection.

Association between interleukin-10 gene polymorphisms (rs1800871, rs1800872, and rs1800896) and severity of infection in different SARS-CoV-2 variants

“…The relationship between rs1800871 and other viral infections was shown in HBV infection. It has been demonstrated that the IL10 rs1800871 C allele and CC genotype can increase the risk of HBV infection [29]. In addition, a higher risk of systemic lupus erythematosus in Iranian patients was observed at the IL10 rs1800871 CC genotype [17].…”

Recent advances in different interactions between toll-like receptors and hepatitis B infection: a review

“…The rs3775290 polymorphism on chromosome 4’s TLR3 gene can inhibit TLR3 activation, hindering pathogen recognition and weakening the immune response, thereby increasing the disease’s infectiousness ( 104 ). A meta-analysis validated the association between the rs3775291 polymorphism and HBV susceptibility, with the T allele and TT genotype enhancing the chances of HBV infection ( 107 ). Rong et al.…”

“…Similarly, they increased the CHB-associated high risk of acute chronic liver failure (ACLF) ( 108 ). A meta-analysis indicated that rs3775291 is a substantial risk factor for HBV-associated liver infection ( 107 , 109 ). Li and Zheng discovered that it is associated with prolonged susceptibility to HBV-associated HCC ( 110 ).…”

Serum Interleukins as Potential Prognostic Biomarkers in HBV-Related Acute-on-Chronic Liver Failure

“…Improve liver histology and reduce fibrosis [ 51 ]. Ye et al included 22 case-control studies for meta-analysis and found that IL-10 rs1800871 polymorphism was associated with HBV risk, and allele C and genotype CC at IL10 rs1800871 locus may increase susceptibility to hepatitis B infection [ 52 ]. A meta-analysis showed that IL-10-1082GA gene polymorphism is associated with susceptibility to persistent HBV infection in the Chinese population, and IL-10-592CA gene polymorphism is associated with HBV clearance in the Chinese population [ 53 ].…”