Association of TNF-α-308G/A, -238G/A, -863C/A, -1031T/C, -857C/T polymorphisms with periodontitis susceptibility

Xu, Lishuo; Liu, Chenguang; Zheng, Youli; Huang, Yu Chen; Zhong, Yang; Zhao, Zhulan; Ma, Ning; Zheng, Zhiming; Zhang, Li

doi:10.1097/md.0000000000021851

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…In total, these polymorphisms may modify the expression and production of IL-1 and TNFα, affect host immune response and susceptibility to inflammatory diseases. Previous studies demonstrated that TNFα G-308A [ 18 , 19 ], IL-1α C-889T [ 20 ] and IL-1β C+3954T [ 21 ] polymorphisms were associated with risk of chronic periodontitis. The association between these polymorphisms with susceptibility to implant failure, marginal bone loss and peri-implantitis have also been widely explored, which, however, yielded inconsistent results [ 22 – 24 ].…”

Section: Introductionmentioning

confidence: 99%

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

2021

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Background Pro-inflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) play important roles in host immune response and bone metabolism during dental implant osseointegration. Whether the functional polymorphisms in IL-1α, IL-1β and TNFα were associated with peri-implant disease was unclear, and we performed the present meta-analysis for this purpose. Methods Eligible studies investigating IL-1α C-889T, IL-1β C+3954T and C-511T, TNFα G-308A, composite genotype of IL-1α C-889T and IL-1β C+3954T for association with peri-implant disease, including peri-implantitis (PI), marginal bone loss (MBL) and implant failure/loss (IF/IL), were searched on several literature databases prior to April 30, 2021. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated for each polymorphism in different genetic models and for composite genotype comparing carriers to non-carriers. Results Twenty-seven studies (1324 cases with peri-implant disease and 1808 controls with healthy implants) were included. There was significant correlation between IL-1α C-889T and peri-implant disease in all genetic models. IL-1β C+3954T was associated with peri-implant disease risk in allelic (OR = 1.66, 95%CI 1.17–2.35, p = 0.004) and dominant model (OR = 1.74, 95%CI 1.19–2.53, p = 0.004), and in subgroups of Asians, Caucasians, non-smokers, IF/IL and PI. TT genotype of IL-1β C-511T increased the risk of peri-implant disease (OR = 1.68, 95%CI 1.15–2.43, p = 0.007) and MBL (OR = 4.33, 95%CI 1.72–10.9, p = 0.002) compared to CC+CT genotypes. We did not observed a significant association between TNFα G-308A and peri-implant diseases in overall or subgroups analysis. Carriers of positive composite genotype of IL-1α C-889T and IL-1β C+3954T had 1.95-fold (95%CI 1.35–2.80, p<0.001) risk of peri-implant disease and 1.76-fold (95%CI 1.05–2.95, p = 0.032) risk of IF/IL than non-carriers. Conclusion Functional polymorphisms of IL-1α (C-889T), IL-1β (C+3954T, C-511T) and composite genotype of IL-1 can be used as predictive markers for peri-implant disease, whereas TNFα G-308A polymorphism was not associated with peri-implant disease.

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Section: Introductionmentioning

confidence: 99%

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

2021

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“…For TNF-α ─ 857 G/A SNP, our analysis revealed a significantly lower frequency of AA genotype in CP patients; however, no significant differences were observed in terms of allele frequencies. Xu et al [42] in a meta-analysis in 2020 found no association between TNF-α ─ 857 G/A SNP and CP susceptibility.…”

Section: Discussionmentioning

confidence: 96%

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Saremi

Shafizadeh

Ghaffari

et al. 2022

Egypt J Med Hum Genet

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Background Chronic periodontitis (CP) is a prevalent infectious disease caused by an interplay between pathogens and immune responses. Gene polymorphisms are among the factors that affect susceptibility to CP. This study aimed to assess the association between CP and single nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10), interleukin 1ß (IL-1ß), and tumor necrosis factor-α (TNF-α) genes. Methods A total of 87 patients with CP and 89 healthy controls were included in this study. Venous blood samples were obtained, and DNA was extracted and purified. Segments containing the relevant genes were amplified by polymerase chain reaction (PCR). Electrophoresis was performed after restriction fragment length polymorphism (RFLP) to determine genotype and allele frequencies. Results The CP group showed significantly different allele and genotype frequencies for three out of five SNPs: IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, and IL-1ß + 3954 C/T (p < 0.05). Additionally, the frequency of the TNF-α ─ 857 AA genotype was significantly lower in patients compared with controls (p = 0.034); however, no significant differences were found in allele frequencies (p > 0.05). Logistic regression analysis revealed that carriers of IL-10 ─ 592 A allele and IL-1ß + 3954 T allele are at higher risk of CP (p < 0.001). Allele and genotype frequencies for TNF-α ─ 308 G/A did not differ significantly between patients and controls (p > 0.05). Conclusions This study showed specific genotypes of IL-10 ─ 592 C/A, IL-10 ─ 819 C/T, IL-1ß + 3954 C/T, and TNF-α ─ 857 G/A SNPs may be associated with an increased risk of CP development.

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“…Other meta-analysis, however, supported that variant A of the TNF-α (G −308A) polymorphism may contribute to chronic periodontitis and aggressive periodontitis susceptibility, particularly in Asians and Caucasians [76]. In another meta-analysis, the TNF-α −308G/A polymorphism was significantly associated with decreased risks of chronic periodontitis and aggressive periodontitis in Asians [77]. There were no associations between TNF-α −238G/A, −863C/A, −1031T/C, −857C/T polymorphism and susceptibility to aggressive periodontitis.…”

Section: Cytokinesmentioning

confidence: 99%

Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review

Brodzikowska

Górski

2022

Biomolecules

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Current evidence pinpoints that the variability in periodontitis traits in humans may be attributable to genetic factors. Different allelic variants can result in alterations in tissue structure, antibody responses and inflammatory mediators. Consequently, genetic variations may act as protective or risk factors for periodontal diseases. A number of features of the inflammatory and immune response that seem to play a role in the development of periodontitis have a clearly established genetic basis. Identifying genes that contribute to the pathogenesis of periodontitis may be utilized for risk assessment in both aggressive and chronic periodontitis. The aim of this narrative review is to summarize the role of polymorphisms in genes involved in inflammation and periodontitis, including cellular receptors, tissue compatibility antigens, antibodies and cytokines.

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Association of TNF-α-308G/A, -238G/A, -863C/A, -1031T/C, -857C/T polymorphisms with periodontitis susceptibility

Abstract: Supplemental Digital Content is available in the text

Cited by 8 publications

References 44 publications

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Association between common polymorphisms in IL-1 and TNFα and risk of peri-implant disease: A meta-analysis

Evaluation of interleukin 10, interleukin 1-beta, and tumor necrosis factor-alpha gene polymorphisms in patients with periodontitis and healthy controls

Polymorphisms in Genes Involved in Inflammation and Periodontitis: A Narrative Review

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